Biomembrane transport / Lon J. Van Winkle ; with contributions by Ovidio Busolati ... [et al.].

Format:

Book

Author/Creator:

Van Winkle, Lon J.

Language:

English

Subjects (All):

Biological transport.

Cell membranes.

Membranes (Biology).

Physical Description:

1 online resource (412 p.)

Place of Publication:

San Diego : Academic Press, c1999.

Language Note:

English

Summary:

Biomembrane Transport covers the fundamental principles of biomembrane transport proteins, including thermodynamics and kinetics, structure and catalytic mechanism, and regulation and integration classification. The book considers recent advances in transport protein structure and function, along with established concepts. The importance of biomembrane transport to regulation and interorgan nutrient flows and metabolism is covered, as well as classical and modern techniques for characterizing transport. The book also contains a classification scheme for all known transport proteins acco

Contents:

Front Cover; Biomembrane Transport; Copyright Page; Contents; Foreword; Preface; Chapter 1. Importance of Biomembrane Transport; I. Introduction; II. Solute and Solvent Fluxes Are Determined by Barriers and Propelling Forces; III. Biomembrane Transport in Context; IV. Summary; Chapter 2. Biomembrane Composition, Structure, and Turnover; I. Introduction; II. Is the Fluid Mosaic Model of Membrane Structure Still Adequate?; III. Some Components of the Biomembrane Can Be Reconstituted; IV. How Are Biomembrane Composition and Structure Regulated?; V. Summary

Chapter 3. Thermodynamics and TransportI. Introduction; II. Similar Mathematical Expressions Serve for the Free Energy Change in a Chemical Reaction and in the Migration of a Solute or Solvent; III. Changes in Enthalpy and Entropy May Contribute Differently to the Free Energy Changes Associated with a Biochemical Reaction and Migration of a Solute; IV. The Total Chemical Potential Change for a Transport Process Also May Have an Electrical Component; V. The Gibbs-Donnan Effect Also Generates Osmotic Pressure; VI. Chemical Reactions Drive Primary Active Transport

VII. Reversal of Transport May Drive Chemical ReactionsVIII. How Do Fluctuations in the Local Hydrogen Ion Potential Facilitate Formation of Phosphoric Acid Anhydride Bonds by the Mitochondrial FoFIATP Synthase?; IX. Conversion of Solute Total Chemical Potential Gradients to Gradients of Other Solutes during Co- and Countertransport; X. Dissipation of Solute Gradients through Mediated Transport Processes May Also Perform Work; XI. Application of Thermodynamic Principles to the Solution of Practical Transport Problems; XII. Summary; Chapter 4. Transport Kinetics; I. Introduction

II. Kinetics of DiffusionIII. How Do Measurements of both the Diffusional and the Osmotic Permeability Coefficient for Water Inform Us about the Mechanism of Water Transport across a Plasma Membrane?; IV. Do Lipophilic Substances Migrate across Biomembrane Phospholipid Bilayers by Simple Diffusion?; V. Lipid-Soluble Substances Are Used to Attempt to Measure the Width of Unstirred Water Layers on Either Side of Biomembranes

VI. Do Such Determinations of the Apparent Widths of Unstirred Water Layers Reflect the Intended Physical Phenomenon or Our Ignorance of How Lipid-Soluble Substances Cross Biomembranes?VII. Protein versus Lipid-Mediated Mechanisms of Fatty Acid Migration across Biomembranes; VIII. Protein-Mediated Biomembrane Transport Is Probably Always Substrate Saturable; IX. Kinetics of Saturable Transport; X. Identification and Minimization or Deduction of Processes That May Obscure a Transport Process of Interest

XI. Kinetic Differences among Substrate-Saturable Transport Processes That Form, Propagate, or Dissipate Solute Gradients

Notes:

Description based upon print version of record.

Includes bibliographical references (p. 345-385) and index.

ISBN:

1-281-04697-3

9786611046972

0-08-052810-4

OCLC:

476104520