Loomis's essentials of toxicology / Ted A. Loomis, A. Wallace Hayes.

Format:

Book

Author/Creator:

Loomis, Ted A.

Contributor:

Hayes, A. Wallace (Andrew Wallace), 1939-

Language:

English

Subjects (All):

Toxicology.

Pharmacology.

Physical Description:

1 online resource (295 p.)

Edition:

4th ed.

Other Title:

Essentials of toxicology

Place of Publication:

San Diego : Academic Press, c1996.

Language Note:

English

Summary:

Loomis's Essentials of Toxicology is an introductory text on the science of harmful biologic effects associated with exposures to chemicals of all types. The scope of this book includes a discussion of the major types of chemicals involved; the general properties of chemicals and biologic systems as they influence the occurrence of detrimental biologic effects; the methods used to demonstrate these effects; and the basis for clinical diagnosis and therapy of harmful effects of chemicals on humans. Individual examples are used to demonstrate each of the principles under discussion.Th

Contents:

Front Cover; Loomis's Essentials of Toxicology; Copyright Page; Contents; Preface; Chapter 1. Introduction, Scope, and Principles; History; Scope of Modern Toxicology; Environmental Toxicology; Economic Toxicology; Medical Toxicology; Fundamental Principles in Toxicology; Chapter 2. Numbers in Toxicology; Dose; Dose-Response Relationships; Statistical Concepts and LD50's; Potency versus Toxicity; Safety versus Toxicity; Hypersensitivity and Hyposensitivity; Response Concepts for Compounds Essential to the Biologic System; Chapter 3. Biologic Factors That Influence Toxicity

Absorption and Translocation of ChemicalsReserve Functional Capacity; Accumulation and Storage of Chemicals in the Organism; Tolerance; Chapter 4. Chemical Factors That Influence Toxicity; Nonspecific Chemical Action; Selective Chemical Action; Effect of Ionization and Lipid Solubility on Translocation of Chemicals; Biotransformation Mechanisms; Chapter 5. Influence of Route of Administration on Systemic Toxicity; Percutaneous Route; Inhalation Route; Oral Route; Parenteral Routes; Chapter 6. Genetic Factors That Influence Toxicity; The Genetic Mechanism; Chemicals as Mutagens

Principles of Genetic-Induced Chemical ToxicityDiscovery and Classification of Genetic-Induced Chemical Toxicity; Genetic Factors in Accumulation of Chemicals; Genetic Factors in Prolongation of Action of Chemicals; Genetic Factors in Increased Sensitivity to Chemicals; Drug-Sensitive Hemoglobins; Genetic Factors in Species and Strain Resistance to Toxicity; Chapter 7. Classification of Harmful Effects of Chemicals; Drug-Induced Toxicity; Chemicals Intentionally Administered to Biologic Specimens; Chemicals Not Intended for Administration to Biologic Specimens

Expected or Normal Effects of ChemicalsUnexpected or Abnormal Effects of Chemicals; Chapter 8. Normal Toxic Effects of Chemicals; Harmful Effects of Chemicals Not Intended for Introduction into Biologic Systems; Harmful Effects of Chemicals Intended for Introduction into Biologic Systems; Chapter 9. Abnormal Response to Chemicals; The Immune Mechanism; Initial Exposure to Haptens -The Sensitizing Systems; Subsequent Exposure to Haptens-The Allergic Reaction; The Immune Mechanism in Toxicology; Immune Mechanisms in Clinical Toxicology; Activation and Suppression of the Immune System

Chapter 10. The Basis of Selective ToxicitySelective Toxicity Due to Translocation Mechanisms; Selective Toxicity Due to Biotransformation Mechanisms; Selective Toxicity Due to the Presence or Absence of Receptors; Chapter 11. The Basis Of Antidotal Therapy; General Principles; Procedures for Decreasing Absorption or Translocation; Procedures for Enhancing Termination of Action or Elimination; Procedures for Elevating the Threshold of Toxicity; Chapter 12. Principles of Biological Tests for Toxicit; Principles of Experimental Toxicologic Methodology; Translocation Factors in Toxicologic Tests

Concentration-Response Factors in Toxicologic Tests

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-281-05385-6

9786611053857

0-08-053563-1

OCLC:

476103272