Update on polymers for ocular drug delivery [electronic resource] / Atish S. Mundada.

Format:

Book

Author/Creator:

Mundada, Atish S.

Series:

Smithers Rapra update.

Smithers Rapra update

Language:

English

Subjects (All):

Drug delivery systems.

Polymers.

Physical Description:

1 online resource (210 p.)

Place of Publication:

Shawbury, Shrewsbury [England] : iSmithers, 2011.

Language Note:

English

Summary:

The eye is the most easily accessible site for topical administration of a medication. Drugs are commonly applied to the eye for localised action on the surface or in the interior of the eye. A major problem in ocular therapeutics is the attainment of an optimal drug concentration at the site of action. Poor bioavailability of drugs from ocular dosage forms is mainly due to the precorneal loss factors which include tear dynamics, non-productive absorption, transient residence time in the cul-de-sac, and the relative impermeability of the corneal epithelial membrane. Due to these physiological

Contents:

9781847355645 _Front Cover.pdf; 9781847355645 _Content.pdf; Update on Polymers for Ocular Drug Delivery; Dedication and Acknowledgements; Contents; Preface; 1 Introduction: Overview of Ocular Drug Delivery; 1.1 Drug Delivery and Polymer Science; 1.2 Ocular Drug Delivery; 1.2.1 Anatomy and Physiology of the Eye; 1.2.2 Pharmacokinetics of Drugs Delivered through the Ocular Route; References; 2 Conventional Ocular Drug Delivery; 2.1 Introduction; 2.2 Eye Drops; 2.2.1 Aqueous Solutions; 2.2.2 Ophthalmic Suspensions; 2.3 Semisolids; 2.4 Summary and Conclusion; References

3 Hydrogels and Viscosity Modifiers3.1 Introduction; 3.2 Hydrogels; 3.2.1 Sodium Hyaluronate; 3.2.2 Cellulose Derivatives; 3.2.3 Polyvinyl Alcohol; 3.2.4 Carbomers; 3.2.5 Miscellaneous Polymers; 3.3 Viscosity Enhancing Agents; 3.3.1 Cellulose Derivatives; 3.3.2 Acrylates; 3.3.3 Hyaluronic Acid; 3.3.4 Chitosan; 3.3.5 Thiomers; 3.3.6 Others; 3.4 Summary and Conclusion; References; 4OcularInserts; 4.1Introduction; 4.2OcularInsertsasDrugDeliverySystems; 4.2.1 Soluble Ocular Drug Inserts; 4.2.1.1 Inserts Based on Natural Polymers; 4.2.1.2 Inserts Based on Synthetic and Semisynthetic Polymers

4.2.1.3 Inserts Utilising Particular Approaches4.2.1.3.1 The Mucoadhesive Approach; 4.2.1.3.2 The Prodrug Approach; 4.2.1.3.3 The Drug Carrier Approach; 4.2.2 Insoluble Ocular Drug Inserts; 4.2.2.1 Diffusional Inserts; 4.2.2.2 Osmotic Inserts; 4.2.2.3 Contact Lenses; 4.2.3 Bioerodible Inserts; 4.3SummaryandConclusion; References; 5 Particulate Drug Delivery; 5.1 Introduction; 5.2 Nanoparticles and Polymers used in their Preparation; 5.2.1 Acrylates; 5.2.1.1 Polyalkylcyanoacrylate; 5.2.1.2 Acrylate Derivatives; 5.2.2 Polyester-based Nanoparticles; 5.2.2.1 Poly-e-caprolactone

5.2.2.2 Poly(D,L-lactic acid) and Poly(D,L-lactide-co-glycolide)5.2.3 Natural Polymer Based Nanoparticles; 5.2.3.1 Protein Nanoparticles; 5.2.3.2 Polysaccharide Based Nanoparticles; 5.2.3.3 Lipid Based Nanoparticles; 5.2.4 Polymeric Coating to Nanoparticles; 5.3 Microparticles and Polymers used in their Preparation; 5.3.1 Ocular Delivery of Drug Loaded Microparticulates; 5.3.2 Polymers used in the Preparation of Microparticulates; 5.3.2.1 Acrylates; 5.3.2.2 Poly(D,L-lactic acid) and Poly (D,L-lactide-co-glycolide); 5.3.2.3 Natural Polymers; 5.3.2.4 Lipids; 5.4 Summary and Conclusion

5.2.4.1 Polysaccharide Coating5.2.4.2 Polyacrylic Coating; 5.2.4.3 Polyethylene Glycol Coating; References; 6 In Situ Gelling Polymers in Ocular Drug Delivery; 6.1 Introduction; 6.2 In Situ Gelling Hydrogels; 6.2.1 Temperature-induced In Situ Gelling Polymeric Carriers; 6.2.1.1 Poloxamers (Pluronic) and their Analogues; 6.2.1.2 Xyloglucan; 6.2.1.3 Cellulose Derivatives; 6.2.2 pH-induced In Situ Gelling Polymeric Carriers; 6.2.2.1 Carbomers; 6.2.2.2 Pseudolatexes; 6.2.3 Osmotically Induced In Situ Gelling Polymeric Carriers; 6.2.3.1 Gellan Gum (Gelrite); 6.2.3.2 Alginates

6.2.4 Dual Mechanism based In Situ Gelling Polymeric Carriers

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-280-12528-4

9786613529145

1-84735-564-1

OCLC:

777830098