Immunopharmacology of the respiratory system / edited by Stephen T. Holgate.

Format:

Book

Contributor:

Holgate, Stephen T. (Stephen Townley)

Series:

Handbook of immunopharmacology.

Handbook of immunopharmacology

Language:

English

Subjects (All):

Respiratory organs.

Immunopharmacology.

Physical Description:

1 online resource (286 p.)

Place of Publication:

London : Academic Press, 1995.

Language Note:

English

Summary:

Immunopharmacology represents the boundary between the immune system and chemical mediators of the inflammatory and neuroendocrine responses. The subject as applied to the respiratory system embraces most of the common non-malignant lung diseases of which asthma and allied disorders are the most prevalent. An understanding of the underlying mechanisms of the disorders provides rationale for prevention and drug treatment as well as creating opportunities for novel drug development. This volume embraces all of these principles and should enable the reader to become rapidly updated in an area of

Contents:

Front Cover; Immunopharmacology of the Respiratory System; Copyright Page; Contents; Contributors; Series Preface; Preface; Chapter 1. Macrophage and Dendritic Cell Populations in the Respiratory Tract; 1. Introduction; 2. Macrophage-Dendritic Cell Interactions; 3. Macrophage-Dendritic Cell Regulation of T Cell Function(s) in Inflamed Lung and Airway Tissues; 4. References; Chapter 2. The Role of T Lymphocytes in Mucosal Protection and Injury; 1. Introduction; 2. T Lymphocyte-derived Cytokines; 3. Functional Heterogeneity of T Lymphocytes in Human Immune Responses

4. The Role of Cytotoxic T Lymphocytes in Mucosal Protection Against Invading Microorganisms5. Suppression of Immune Responses by T Lymphocytes at Mucosal Surfaces; 6. Accumulation of T Lymphocytes at Mucosal Sites; 7. T Lymphocytes and the Regulation of Immunoglobulin Synthesis; 8. The Role of T Lymphocytes in Recruitment of Granulocytes to Mucosal Surfaces; 9. Summary; 10. References; Chapter 3. The Regulation of Immunoglobulin E Synthesis; 1. Introduction; 2. Characteristics of the Human IgE Response; 3. The Structure of IgE; 4. IgE and its Receptors; 5. Molecular Organization of IgE

6. Control of IgE Synthesis by Cytokines7. Control of IgE Synthesis by Cell Surface Molecules; 8. CD4 + T Cell Production of IgE Regulatory Cytokines; 9. CD8+TCelIs; 10. Conclusions; 11. References; Chapter 4. Mast Cells and Basophils: Their Role in Initiating and Maintaining Inflammatory Responses; 1. Introduction; 2. Mast Cell Development; 3. Mast Cell Heterogeneity; 4. Preformed Mast Cell Mediators; 5. Newly Generated Mediators; 6. Mast Cell Cytokines; 7. Mast Cells and Basophils in Disease; 8. Conclusions; 9. Acknowledgements; 10. References

Chapter 5. Eosinophils: Effector Leukocytes of Allergic Inflammatory Responses1. Eosinophils and the Pathophysiology of Asthma; 2. Mechanism of Selective Eosinophil Recruitment into the Airways; 3. Eosinophil Effector Mechanisms; 4. Regulation of Eosinophil Function; 5. Eosinophil-Lymphocyte Interactions; 6. Conclusion; 7. References; Chapter 6. Cytokine Regulation of Chronic Inflammation in Asthma; 1. Introduction; 2. Cellular Origins; 3. Cytokine Receptors; 4. Cytokine Effects; 5. The Cytokine Network in Chronic Asthma; 6. Therapeutic Implications; 7. Conclusions; 8. References

Chapter 7. Neural Networks in the Lung1. Introduction; 2. Tachykinins; 3. Vasoactive Intestinal Peptide; 4. Nitrogen Oxides; 5. Summary; 6. References; Chapter 8. The Microvasculature as a Participant in Inflammation; 1. Background; 2. Airway Microvasculature; 3. Increased Vascular Permeability in Airway Inflammation; 4. Mechanism of Increased Vascular Permeability in Inflammation; 5. Inflammatory Mediators that Increase Vascular Permeability; 6. Changes in the Airway Microvasculature in Chronic Inflammation; 7. Effect of Anti-inflammatory Drugs on Plasma Leakage; 8. Summary and Conclusions

9. Acknowledgements

Notes:

Description based upon print version of record.

Includes bibliographical references.

ISBN:

1-281-03826-1

9786611038267

0-08-053455-4

OCLC:

476100634