Treatment landscape of targeted therapies in oncology challenges and opportunities edited by Pawan Kumar Maurya, Vikas Saini

Format:

Book

Contributor:

Maurya, Pawan Kumar, editor.

Saini, Vikas, editor.

Language:

English

Subjects (All):

Cancer--Treatment--Technological innovations.

Cancer.

Immunotherapy.

Cancer--Immunotherapy.

Neoplasms--therapy.

Molecular Targeted Therapy.

Medical Subjects:

Neoplasms--therapy.

Immunotherapy.

Molecular Targeted Therapy.

Physical Description:

1 online resource

Place of Publication:

London Academic Press [2023]

Summary:

Treatment Landscape of Targeted Therapies in Oncology: Challenges and Opportunities provides up-to-date knowledge on antitumor-targeted therapies and immunotherapy. The book's chapters are written by researchers dynamically working/focusing on cancer treatment. The content is designed to help those who are new to the field (beginners) and various specialized scientists and researchers involved in cancer research. For decades, the hallmark of cancer treatment has been conventional chemotherapy. But with the rapid increase in our understanding of the immune system, more and more small molecules, peptides, recombinant antibodies, vaccines and cellular therapeutic modalities are being applied to manipulate the immune response for cancer treatment

Contents:

Intro

Title page

Table of Contents

Copyright

List of contributors

Preface

Chapter 1. Biology of cancer: current insights and perspectives

Abstract

Introduction

A perspective on cancer cell

Epidemiology of cancer

Clinical features and diagnosis

Current and emerging treatment strategies

Modern challenges in cancer therapy

Emerging/advanced treatment strategies

Conclusion and future perspectives

References

Chapter 2. Evolution of targeted therapies in cancer: opportunities and challenges

Types of cancer

Lung cancer

Breast cancer

Colorectal cancer

Brain cancer

Blood cancer

Skin cancer

Cervical cancer

Targeted therapies in cancer

Monoclonal antibodies

Small molecule inhibitors

Targeted immunotherapy

Nanomaterials in cancer therapy

Opportunities and challenges of targeted cancer therapy

Conclusions

Acknowledgments

Conflict of interest

Glossary words

Essay type questions

Chapter 3. Clinical implementation of biomarkers and signaling pathway as novel targeted therapeutics in breast cancer

Background

Factors affecting breast cancer

Classification of breast cancer

Biomarkers in breast cancer: diagnostic to targeted therapy

Targeting molecular signaling pathways

HER2-positive targeted therapies

HER2-negative targeted therapies

Targeted therapy as emerging treatment options

Conclusion and future perspective

Chapter 4. Targeted therapies in advanced lung cancerâ€"current landscapes and future projects

What are targeted therapies

Large molecule inhibitors

Immunotherapy

Small molecule inhibitors and their targets

Acknowledgment

References

Chapter 5. Targeted therapies: emerging biomarkers in advanced melanoma

Biomarkers in melanoma (prognostic and predictive)

Malignant melanoma classification, diagnosis and treatment

Nanotechnology: mechanisms and nanoparticles in melanoma therapies

Nanosystems for improved targeted therapies in melanoma

Conclusion

Chapter 6. Targeting immune checkpoints for cancer therapy

Immune checkpoints

Cytotoxic T-lymphocyte-associated antigen-4 signaling pathway: a promising therapeutic target in cancer

Anti-PD-1/PDL-1 therapy

Targeting mammalian target of rapamycin pathway for cancer therapy

Vascular endothelial growth factor pathway in cancer therapy

Targeting PI3k/Akt pathway

Targeting mitogen-activated protein kinases network for cancer prevention

Inhibition of cyclin-dependent kinases for cancer therapy

Inhibiting epidermal growth factor receptor and human epidermal growth factor receptor 2 for cancer therapy

Chapter 7. Glioblastoma targeted therapies: updated approaches from recent biological insights

Abbreviations

Various therapies for glioblastoma multiforme

Chapter 8. Current trends and future prospects of molecular targeted therapy in head and neck squamous carcinoma

Epidemiology

Symptoms and pathophysiology

Diagnosis and prevention

Therapeutic strategies

Existing therapies

Future prospects

Summary

Chapter 9. Targeted therapy and drug resistance in gastric and pancreatic cancer

Targeted therapy and drug resistance in gastric cancer

Targeted therapy and drug resistance in pancreatic cancer

Chapter 10. Colorectal cancer heterogeneity and targeted therapy: clinical implications, challenges, and solutions for treatment resistance

Molecular biology in metastatic colorectal cancer

Systemic therapy in metastatic colorectal cancer

Chemotherapy backbone for metastatic colorectal cancer

Targeted therapy in first-line setting metastatic colorectal cancer

Anti-VEGF: bevacizumab

Antiepidermal growth factor receptor: cetuximab, panitumumab

BRAF-mutated

KRAS-G12C-mutation in mCRC

Elderly/frail patients

Treatment alternatives after first-line

Anti-VEGF

Antiepidermal growth factor receptor

Anti-BRAF+antiepidermal growth factor receptor

Treatment alternatives in later lines

Tyrosine kinase inhibitors

Thymidine-based nucleoside analogs

Human epidermal growth factor receptor r2-directed therapy

Rare actionable fusion proteins

Local ablative therapy

Chapter 11. Endometrial cancer: molecular markers and management of advanced-stage disease

Type 1 versus type 2

Classification of endometrial cancer on molecular basis

Molecular markers of endometrial cancer

Management of endometrial cancer

Risk factors for endometrial cancer

Statements and declaration

Glossary items

Essay-type questions

Index

Notes:

Includes bibliographical references and index

Description based on online resource; title from digital title page (viewed on September 28, 2023)

Other Format:

Print version Maurya, Pawan Kumar Treatment Landscape of Targeted Therapies in Oncology

ISBN:

9780443160356

044316035X

OCLC:

1392043611

Access Restriction:

Restricted for use by site license