How Does Metabolism Influence the Function of Different T Cell Types?.

Format:

Video

Series:

Academic Video Online

Language:

English

Subjects (All):

T cells.

Immunotherapy.

Physical Description:

1 online resource (7 minutes)

Place of Publication:

[Place of publication not identified] : Latest Thinking, [date of publication not identified]

System Details:

video file

Summary:

T cells are an important component of the body's immune system. As ERIKA PEARCE explains, there are several types of T cells which form consecutively during the immune response and serve different purposes. Effector T cells combat pathogens from infections or tumors while memory T cells provide protective immunity to prevent re-infection or reoccurring cancer. The research presented in this video investigates how the metabolism of the T cells influences the development of effector and memory T cells by blending in vitro and in vivo approaches. The findings show that the morphology of the mitochondria determines the ability of different types of T cells to perform their functions. Furthermore, the researchers were able to modify the mitochondria in a way that the resulting T cells would provide a better immunity against cancer. These insights open up new possibilities to alter immune cell function and thus might lead to improved immunotherapy.

Notes:

Title from resource description page (viewed August 24, 2020).

Part of the metadata in this record was created by AI.