Dual-Mode Electro-photonic Silicon Biosensors / by José Juan Colás.

Format:

Book

Author/Creator:

Juan Colás, José., Author.

Series:

Springer Theses, Recognizing Outstanding Ph.D. Research, 2190-5053

Language:

English

Subjects (All):

Biophysics.

Optical materials.

Electronics--Materials.

Electronics.

Electrochemistry.

Physical measurements.

Measurement.

Surfaces (Physics).

Interfaces (Physical sciences).

Thin films.

Biological and Medical Physics, Biophysics.

Optical and Electronic Materials.

Measurement Science and Instrumentation.

Surface and Interface Science, Thin Films.

Local Subjects:

Biological and Medical Physics, Biophysics.

Optical and Electronic Materials.

Electrochemistry.

Measurement Science and Instrumentation.

Surface and Interface Science, Thin Films.

Physical Description:

1 online resource (XV, 149 p. 105 illus., 89 illus. in color.)

Edition:

1st ed. 2017.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2017.

Summary:

This highly interdisciplinary thesis reports ontwo innovative photonic biosensors that combine multiple simultaneous measurements to provide unique insights into the activity and structure of surface immobilized biological molecules. In addition, it presents a new silicon photonic biosensor that exploits two cascaded resonant sensors to provide two independent measurements of a biological layer immobilized on the surface. By combining these two measurements, it is possible to unambiguously quantify the density and thickness of the molecular layer; here, the approach’s ability to study molecular conformation and conformational changes in real timeis demonstrated. The electrophotonic biosensor integrates silicon photonics with electrochemistry into a single technology. This multi-modal biosensor provides a number of unique capabilities that extend the functionality of conventional silicon photonics. For example, by combining the complementary information revealed by simultaneous electrochemical and photonic measurements, it is possible to provide unique insights into on-surface electrochemical processes. Furthermore, the ability to create electrochemical reactions directly on the silicon surface provides a novel approach for engineering the chemical functionality of the photonic sensors. The electrophotonic biosensor thus represents a critical advance towards the development of very high-density photonic sensor arrays for multiplexed diagnostics.

Contents:

Introduction

Fundamentals of Label-Free Biosensing

Fabrication and Experimental Techniques

The Electro-photonic Silicon Biosensor

Study and Application of Electrografted Layers of Diazonium Ions

Tailoring Light-matter Interaction for Quantification of Biological and Molecular Layers

Conclusions and Outlook.

Notes:

Includes bibliographical references at the end of each chapters.

ISBN:

3-319-60501-1