Discovery of Small-Molecule Modulators of Protein–RNA Interactions for Treating Cancer and COVID-19 / by Wan Gi Byun.

Format:

Book

Author/Creator:

Byun, Wan Gi, author.

Series:

Springer Theses, Recognizing Outstanding Ph.D. Research, 2190-5061

Language:

English

Subjects (All):

Bioengineering.

Biotechnology.

Biophysics.

Protein folding.

RNA interference.

Biological and Physical Engineering.

Chemical Bioengineering.

Protein Folding.

RNA Interference.

Local Subjects:

Biological and Physical Engineering.

Chemical Bioengineering.

Biophysics.

Protein Folding.

RNA Interference.

Physical Description:

1 online resource (156 pages)

Edition:

1st ed. 2023.

Place of Publication:

Singapore : Springer Nature Singapore : Imprint: Springer, 2023.

Summary:

This book describes the development of novel protein–RNA-binding assays and their applications in a high-throughput manner for the identification of small-molecule modulators of protein–RNA interactions to treat cancer and COVID-19. Modulating protein–RNA interactions with small molecules is expected to provide novel biological insights of the interrelation of diseases with the protein–RNA interactome. The modulations may also be exploited therapeutically. For these reasons, the development of a simple, reliable, and sensitive protein–RNA-binding assay is necessary for high-throughput screening to discover new effective chemical entities capable of acting on diverse protein–RNA interactions. This book discusses the discovery of small-molecule modulators targeting protein–RNA interactions that are potentially valuable to treat cancer and COVID-19 by constructing novel high-throughput screening methods. The results of this dissertation provide valuable insights into the regulation of protein–RNA interactions in chemical biology and drug development.

Contents:

1. Introduction

2. Identification of Small-Molecule Inhibitors of Oncogenic Lin28–Let-7 Interaction

3. Discovery of Small-Molecule Modulators of Protein–RNA Interactions by Fluorescence Intensity-Based Binding Assay

4. Harnessing Stress Granule Formation by Small Molecules to Inhibit the Cellular Replication of SARS-CoV-2

Appendix.

Notes:

"Doctoral thesis accepted by Seoul National University, Seoul, Korea (Republic of)"

Description based on publisher supplied metadata and other sources.

Other Format:

Print version: Byun, Wan Gi Discovery of Small-Molecule Modulators of Protein-RNA Interactions for Treating Cancer and COVID-19

ISBN:

9789811978142

OCLC:

1355218110