Hemodynamic Adaptation Mechanisms of Heart Failure to Percutaneous Venoarterial Extracorporeal Circulatory Support / Pavel Hála.

Format:

Book

Author/Creator:

Hála, Pavel, author.

Language:

English

Subjects (All):

Internal medicine.

Hemodynamics.

Physical Description:

1 online resource (92 pages)

Edition:

First edition.

Place of Publication:

Prague : Karolinum Press, [2021]

Summary:

Monografie zaměřená na vliv mimotělních podpor oběhu na systémovou hemodynamiku a práci levé komory. Shrnuje historii, využití a dopady venoarteriálních oběhových podpor u pacientů s dekompenzovaným srdečním selháním. Text je dále doplněn o výsledky vlastních experimentů prováděných na modelech akutního a chronického srdečního selhání a jejich uvedení do kontextu aktuálních fyziologických poznatků.

Contents:

Cover

Contents

Acknowledgments

Abbreviations

Abstract

1 Introduction

1.1 Heart failure

1.1.1 Pathophysiology of HF

1.1.2 Integration of Cardiac and Vascular Changes

1.1.3 Compensatory mechanisms in HF

1.1.4 Clinical presentation

1.1.5 Therapy and prognosis

1.1.6 Acute management strategies

1.2 Heart failure models

1.3 ECLS

1.3.1 Definition of ECLS

1.3.2 History of ECLS

1.3.3 Indications and incidence of ECMO

1.3.4 Anatomy of ECMO

1.3.5 Pathophysiology of VA ECMO

1.3.6 Monitoring of ECMO circuit

1.3.7 Complications of ECMO

1.3.8 Hemodynamics of VA ECMO

2 Hypotheses

3 Aims

4 Methodology

4.1 Animal model of chronic heart failure

4.2 Animal model of acute HF induced by regionalcoronary hypoxemia

4.3 Animal model of acute HF induced by globalcoronary hypoxemia

4.4 Animal model of right-sided HF

4.5 Experimental preparation and hemodynamicmonitoring

4.6 Left ventricular parameters and stroke workanalysis

4.7 ECMO instrumentation

4.8 Experimental ECMO protocols and data acquisition

4.9 Statistical analysis

5 Results

5.1 Characteristics of developed chronic HF model

5.2 Characteristics of acute HF model induced byregional coronary hypoxemia

5.3 Characteristics of acute HF model induced byglobal coronary hypoxemia

5.4 Characteristics of right-sided HF model

5.5 Effects of EBF on chronic HF

5.6 Effects of EBF on acute HF

6 Discussion

6.1 Comments on HF animal models

6.2 EBF effects on chronic HF

6.3 EBF effects on acute HF

6.4 Correlation of tissue saturation and perfusion

6.5 Effects of flow pulsatility

6.6 Clinical considerations

6.7 Study limitations

7 Conclusions

8 List of linked documents

9 References.

Notes:

Includes bibliographical references.

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Other Format:

Print version: Hála, Pavel Hemodynamic Adaptation Mechanisms of Heart Failure to Percutaneous Venoarterial Extracorporeal Circulatory Support

ISBN:

9788024648996

OCLC:

1306056295