Drug Repurposing : Hypothesis, Molecular Aspects and Therapeutic Applications / edited by Farid A. Badria.

Format:

Book

Contributor:

Badria, Farid A., editor.

Language:

English

Subjects (All):

Drug development.

Physical Description:

1 online resource (234 pages)

Edition:

1st ed.

Other Title:

Drug Repurposing

Place of Publication:

London, England : IntechOpen, 2020.

Summary:

Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to provide readers with an informative, illustrative, and easy-to-read book useful for students, clinicians, and the pharmaceutical industry.

Contents:

Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications

Contents

Preface

Section 1 Drug Repurposing: Principles Risk-Benefits and Economic Impacts on Drug Discovery

Chapter1 Drug Repurposing (DR): An Emerging Approach in Drug Discovery

Chapter2 Risk-Benefit Events Associated with the Use of Aspirin for Primary Prevention of Cardiovascular Disorders

Section 2 NewTherapeutic Applications of Old Drugs

Chapter3 Drug Repurposing in Dermatology: Molecular Biology and Omics Approach

Chapter4 Drug Repurposing and Orphan DiseaseTherapeutics

Chapter5 Drug Repurposing in Neurological Diseases: Opportunities and Challenges

Chapter6 Drugs Repurposing for Multi-Drug Resistant Bacterial Infections

Section 3 Drug Repurposing Advances in Oncology

Chapter7 Drug Repurposing in Oncotherapeutics

Chapter8 Drug Repositioning for theTreatment of Glioma: Current State and Future Perspective

Chapter9 Repurposing Infectious PathogenVaccines in Cancer Immunotherapy

Section 4 Repositioning of Old Chemicals for NewTherapeutic Uses

Chapter10 Salicylic Acid Sans Aspirin in Animals and Man

Chapter11 Repurposing Fumaric Acid Esters toTreat Conditions of Oxidative Stress and Inflammation: A Promising Emerging Approach with Broad Potential.

Notes:

Description based on publisher supplied metadata and other sources.