Drug-acceptor interactions : modeling theoretical tools to test and evaluate experimental equilibrium effects / Niels Bindslev.

Format:

Book

Author/Creator:

Bindslev, Niels, author.

Language:

English

Subjects (All):

Drug interactions--Data processing.

Drug interactions.

Drug interactions--Databases.

Physical Description:

1 online resource (xviii, 410 pages)

Place of Publication:

[Place of publication not identified] : Taylor & Francis, 2008.

Summary:

Drug-Acceptor Interactions: Modeling theoretical tools to test and evaluate experimental equilibrium effects suggests novel theoretical tools to test and evaluate drug interactions seen with combinatorial drug therapy. The book provides an in-depth, yet controversial, exploration of existing tools for analysis of dose-response studies at equilibrium or steady state. The book is recommended reading for post-graduate students and researchers engaged in the study of systems biology, networks, and the pharmacodynamics of natural or industrial drugs, as well as for medical clinicians interested in drug application and combinatorial drug therapy. Even people without mathematical skills will be able to follow the pros and cons of reaction schemes and their related distribution equations. Chapter 9 is a hands-on guide for software to plot, fit and analyze one's own data.

Contents:

Part I ONE-STATE MODELS: SIMPLE AGONISM AND ANT-AGONISM

CHAPTER 1 Simple agonism

CHAPTER 2 Simple ant-agonism simple intervention

CHAPTER 3 Auto-inhibition and auto-intervention in one-state models

CHAPTER 4 Means of obtaining ant-agonist constants: Preliminary points of a personal view

Part II TWO-STATE MODELS: COMPLEX AGONISM AND MODULATION

CHAPTER 5 Complex agonism

CHAPTER 6 Multi-step reaction schemes: extending the two-step mechanism of del Castillo and Katz

CHAPTER 7 Cubic reaction schemes. ATSM and HOTSM

Part III TEST OF TOOLS FOR DATA ANALYSIS

CHAPTER 8 Choosing and formulating relevant schemes

CHAPTER 9 Plots, fits and data interpretation.

CHAPTER 10 Hill in hell

CHAPTER 11 The Schild against other theories

CHAPTER 12 Ties between synergy and two-state models

Part IV BIOLOGICAL REGULATION AND ALLOSTERY

CHAPTER 13 Strategies of biological regulation

CHAPTER 14 On allostery and co-operativity

CHAPTER 15 Allostery and development of its models.

Notes:

Description based on publisher supplied metadata and other sources.