Animal Models of Acute Neurological Injuries II [electronic resource] : Injury and Mechanistic Assessments, Volume 2 / edited by Jun Chen, Xiao-Ming Xu, Zao C. Xu, John H. Zhang.

Format:

Book

Contributor:

Chen, Jun, Editor.

Xu, Xiao-Ming, Editor.

Xu, Zao C., Editor.

Zhang, J. H. (John H.), Editor.

SpringerLink (Online service)

Series:

Springer protocols (Series) 1949-2456

Springer Protocols Handbooks, 1949-2456

Language:

English

Subjects (All):

Neurosciences.

Neurology.

Biology—Technique.

Neuroscience.

Experimental Organisms.

Local Subjects:

Neuroscience.

Neurology.

Experimental Organisms.

Physical Description:

XVIII, 718 p. online resource.

Edition:

1st ed. 2012.

Contained In:

Springer Nature eBook

Place of Publication:

Totowa, NJ : Humana Press : Imprint: Humana, 2012.

System Details:

text file PDF

Summary:

The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries. Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system. Volume 2 examines global cerebral ischemia, focal cerebral ischemia, and neonatal hypoxia-ischemia, as well as intensive sections covering traumatic brain injury and spinal cord injury. Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used. Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments.

Contents:

Introduction (Parts I-III)

Morphological Assessments of Global Cerebral Ischemia: Viable Cells

Morphological Assessments of Global Cerebral Ischemia: Degenerated Cells

Morphological Assessments of Global Cerebral Ischemia: Electron Microscopy

Biochemical and Molecular Biological Assessments of Global Cerebral Ischemia: mRNA

Biochemical and Molecular Biological Assessments of Global Cerebral Ischemia: Protein

Neurobehavioral Assessments of Global Cerebral Ischemia

Assessment of Neurogenesis in the Dentate Gyrus after Global or Focal Ischemia

Infarct Measurement in Focal Cerebral Ischemia: TTC Staining

Morphological Assessments of Focal Cerebral Ischemia: White Matter Injury

Blood Flow Reduction: Laser Doppler, 14C-IAP

Biochemical and Molecular Biological Assessments of Focal Cerebral Ischemia: mRNA and MicroRNA

Biochemical and Molecular Biological Assessments of Focal Cerebral Ischemia: Protein

Assessments of Inflammation After Focal Cerebral Ischemia

Neurobehavioral Assessments of Focal Cerebral Ischemia: Sensorimotor Deficit

Neurobehavioral Assessments of Focal Cerebral Ischemia: Cognitive Deficit

Assessment of Neurogenesis in Models of Focal Cerebral Ischemia

Assessment of Angiogenesis in Models of Focal Cerebral Ischemia

Morphological Assessments of Neonatal Hypoxia-Ischemia: In Situ Cell Degeneration

Morphological Assessments of Neonatal Hypoxia-Ischemia: White Matter Injury

Biochemical and Molecular Biological Assessments of Neonatal Hypoxia-Ischemia: Cell Signaling

Biochemical and Molecular Biological Assessments of Neonatal Hypoxia-Ischemia: Inflammation

Neurobehavioral Assessments of Neonatal Hypoxia-Ischemia

Assessment of Neurogenesis and White Matter Regeneration

Assessments for Traumatic Brain Injury: An Introduction

Morphological Assessments of Traumatic Brain Injury

Assessment of Cerebral Vascular Dysfunction after Traumatic Brain Injury

Assessment of Membrane Permeability After Traumatic Brain Injury

Assessment of Neurogenesis by BrdU Labeling After Traumatic Brain Injury

Electrophysiological Approaches in Traumatic Brain Injury

Biochemical and Molecular Biological Assessments of Traumatic Brain Injury

Assessments of Oxidative Damage and Lipid Peroxidation after Traumatic Brain Injury and Spinal Cord Injury

Neurobehavioral Assessments of Traumatic Brain Injury

Vestibular Assessments Following Traumatic Brain Injury

Introduction on Assessments for Spinal Cord Injury

Morphological Assessments Following Spinal Cord Injury

Assessment of Lesion and Tissue Sparing Volumes Following Spinal Cord Injury

Retrograde Axonal Tract Tracing

Anterograde Axonal Tract Tracing

Assessments of Gliogenesis After Spinal Cord Injury

Assessing Microvessels After Spinal Cord Injury

Physiological Assessment of Spinal Cord Injury

Electrophysiological Assessment of Spinal Cord Function on Rodents Using tcMMEP and SSEP

Operant Conditioning of Spinal Cord Reflexes in Rats

Cellular and Molecular Biological Assessments of Inflammation and Autoimmunity After Spinal Cord Injury

Neurobehavioral Assessments of Spinal Cord Injury

Basso, Beattie, and Bresnahan (BBB) Scale Locomotor Assessment Following Spinal Cord Injury and Its Utility as a Criterion for Other Assessments

High Speed Video Recording Used for the Analysis of Hand Shaping in Over Ground Walking, Cylinder Exploration, Skilled Reaching, and Rung Walking in Rats

Automated Gait Analysis Following Spinal Cord Injury

Forelimb Functional Assessments of Rats and Mice After Cervical Spinal Cord Injury

Swimming as an Assessment of Hindlimb Function in Animals with Traumatic Spinal Cord Injury

Neuroimaging Assessment of Spinal Cord Injury in Rodents.

Other Format:

Printed edition:

ISBN:

9781617797828