1 option
DNA-Encoded Libraries / edited by Andreas Brunschweiger, Damian W. Young.
- Format:
- Book
- Series:
- Topics in Medicinal Chemistry, 1862-247X ; 40
- Language:
- English
- Subjects (All):
- Pharmaceutical chemistry.
- Physical biochemistry.
- Biology-Technique.
- Biophysics.
- Proteins.
- Medicinal Chemistry.
- Biophysical Chemistry.
- Biophysical Methods.
- Protein Biochemistry.
- Local Subjects:
- Medicinal Chemistry.
- Biophysical Chemistry.
- Biophysical Methods.
- Protein Biochemistry.
- Physical Description:
- 1 online resource (IX, 276 pages)
- Edition:
- 1st ed. 2022.
- Contained In:
- Springer Nature eBook
- Place of Publication:
- Cham : Springer International Publishing : Imprint: Springer, 2022.
- System Details:
- text file PDF
- Summary:
- This book deals with the recent advances in DNA-Encoded Library (DEL) technology that has emerged as an alternative to high throughput screening(HTS) over the last decade and has been heralded as a "disruptive" technology for drug discovery. The book aims to provide a comprehensive overview of all of the major components of the DEL process from conception to bench execution and clinical investigations. The contributions from experts in the field combine different perspectives from academia and industry. The book will be of interest to researchers in the drug discovery field as well as graduate students and scholars who are interested in this rapidly improving technology.
- Contents:
- A History of Selection-Based High-Throughput Screening Technologies for Hit Identification
- Barcoding Strategies for the Synthesis of Genetically Encoded Chemical Libraries
- Advancements in DEL-Compatible Chemical Reactions
- Design Considerations in Constructing and Screening DNA-Encoded Libraries
- Cheminformatics Approaches Aiding the Design and Selection of DNA-Encoded Libraries
- Selection Strategies in DNA-Encoded Libraries
- From DEL Selections to Validated Hits to Clinical Leads
- A Perspective on 30 Years of DNA-Encoded Chemistry. .
- Other Format:
- Printed edition:
- ISBN:
- 9783031186295
- Access Restriction:
- Restricted for use by site license.
The Penn Libraries is committed to describing library materials using current, accurate, and responsible language. If you discover outdated or inaccurate language, please fill out this feedback form to report it and suggest alternative language.