WHO consolidated guidelines on tuberculosis. Module 3 : Diagnosis - tests for tuberculosis infection / World Health Organization.

Format:

Book

Author/Creator:

World Health Organization, author, issuing body.

Language:

English

Subjects (All):

Tuberculosis, Pulmonary--drug therapy.

Tuberculosis, Pulmonary.

Physical Description:

1 online resource (1 PDF file (xvi, 46 pages))

Edition:

1st ed.

Place of Publication:

Geneva : World Health Organization, 2022.

Summary:

The "WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis - Tests for tuberculosis infection" is a new consolidated policy guideline on tests for TB infection. The policy includes, for the first-time recommendations on a new class of Mycobacterium tuberculosis antigen-based skin tests (TBSTs) and consolidates all currently existing recommendations for the diagnosis of TB infection, including the traditional tuberculin skin test (TST) and interferon-gamma release assays (IGRAs). IGRAs and TBSTs use Mycobacterium tuberculosis complex specific antigens and represent a significant advancement to TST which has been used for over half a century. The consolidated guideline provides background, justification, recommendations and implementation considerations on the WHO recommended TB infection tests. This document is accompanied by the "WHO operational handbook on tuberculosis. Module 3: Diagnosis - Tests for tuberculosis infection", which provides laboratory personnel, clinicians as well as ministries of health and technical partners detailed guidance on how to implement the WHO evidence-based recommendations on TB infection tests. The document describes the WHO recommended tests, test procedures, a model algorithm, and the steps required to scale-up TB infection testing.

Contents:

Acknowledgements

Abbreviations and acronyms

Executive summary

1. Use of Mycobacerium tuberculosis antigen-based skin tests for the diagnosis of TB infection NEW

1.1. Background

1.2. Recommendation

1.3. Test descriptions

1.4. Evidence base

1.5. Implementation considerations

1.6. Monitoring and evaluation

1.7. Research priorities

2. Use of the TST and IGRAs for the diagnosis of TB infection

2.1. Background

2.2. Recommendation

2.3. Test descriptions

2.4. Evidence base

2.5. Implementation considerations

2.6. Research priorities

3. Use of the TST and IGRAs for the diagnosis of TB disease

3.1. Background

3.2. Recommendation

3.3. Test descriptions

3.4. Evidence base

3.5. Research priorities

References

Annex 1. Summary of changes between the 2011-2020 guidance and the 2022 update

Annex 2. GDG processes and decision-making

Annex 3. Conflict of interest assessment for Guideline Development Group and External Review Group members

Web annexes

Web Annex A. Accuracy of Mycobacterium tuberculosis antigen-based skin tests: a systematic review and meta-analysis

Review team: Yohhei Hamada, Elena Surkova, Irina Kontsevaya, Ting Ting Wang, Victoria Liu, Liliya Eugenevna Ziganshina, and Molebogeng X Rangaka. Technical advisor: Claudia Denkinger and Ibrahim Abubakar.

Web Annex B. Safety of Mycobacterium tuberculosis antigen-based skin tests: a systematic review and meta-analysis

Review team: Yohhei Hamada, Irina Kontsevaya, Elena Surkova, Ting Ting Wang, Victoria Liu, Liliya Eugenevna Ziganshina, and Molebogeng X Rangaka. Technical advisor: Claudia Denkinger and Ibrahim Abubakar.

Web Annex C. GRADE profiles of Mycobacterium tuberculosis antigen-based skin tests

Web Annex D. Cost-effectiveness of Mycobacterium tuberculosis antigenbased skin tests: a systematic review

Review team: Lara Goscé, Finna Parkinson, Kasim Allel, Elena Surkova, Irina Kontsevaya, Ting Ting Wang, Victoria Liu, Yohhei Hamada, Peter White, and Molebogeng X Rangaka. Technical advisor: Peter White and Ibrahim Abubakar.

Web Annex E. Modelling for economic evidence for the use of Mycobacterium tuberculosis antigen-based skin tests

Lara Goscé, Finna Parkinson, Kasim Allel, Elena Surkova, Irina Kontsevaya, Ting Ting Wang, Victoria Liu, Yohhei Hamada, Peter J White, and Molebogeng X Rangaka.

Web Annex F. Qualitative evidence for the use of Mycobacterium tuberculosis antigen-based skin tests

Review team: Amy Hai Yan Chan, Kate Loveys, Matthew Quaife, Amy Clarke, Liliya Eugenevna Ziganshina, Irina Kontsevaya, Chloe Tuck, Elena Surkova, Ting Ting Wang, Liu (Victoria) Wan-Hsin, Yohhei Hamada, and Molebogeng X Rangaka.

Web Annex G. Mycobacterium tuberculosis antigen-based skin tests: evidence-to-decision table

Web Annex H. Use of tuberculin skin test or interferon gamma release assays for identifying individuals at greatest risk of progression to active TB

Web Annex I. Diagnostic accuracy of interferon gamma release assays for evaluation of patients with pulmonary TB.

Notes:

Description based on publisher supplied metadata and other sources.