Lipoprotein(a) / edited by Karam Kostner, Gerhard M. Kostner, Peter P. Toth.

Format:

Book

Contributor:

Kostner, Karam, editor.

Kostner, Gerhard M., editor.

Toth, Peter P., editor.

Series:

Contemporary Cardiology, 2196-8977

Language:

English

Subjects (All):

Cardiology.

Internal medicine.

Internal Medicine.

Local Subjects:

Cardiology.

Internal Medicine.

Physical Description:

1 online resource (446 pages)

Edition:

1st ed. 2023.

Place of Publication:

Cham : Springer International Publishing : Imprint: Humana, 2023.

System Details:

Mode of access: World Wide Web.

Summary:

Lipoprotein(a) [Lp(a)] is a unique lipoprotein that has emerged as an independent risk factor for cardiovascular vascular disease. Data from case control, epigenetic and mendelian randomization studies indicate that people with elevated Lp(a) have a two-fold to four-fold increased risk of cardiovascular events compared to people with low Lp(a) levels. Despite this risk, awareness of Lp(a) is still very low among health care providers. Even cardiologists often overlook Lp(a), in part because Lp(a) is not as well-understood as other risk factors and treatment options are still very limited. This book offers an authoritative and comprehensive overview of Lipoprotein(a). It provides an in-depth review of all aspects of Lp(a), from pathophysiology to metabolism. Chapters offer the reader a contemporary view of the important roles of Lp(a) as a risk factor for cardiovascular disease. In addition, this volume discusses the clinical implications of elevated Lp(a) and current and future therapies. Lipoprotein(a) is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in lipidology, cardiology, endocrinology, pharmacotherapy, and health promotion and disease prevention.

Contents:

60 years of Lp(a) research-From Ouchterlonys double diffusion to a significant risk factor for CHD

Lp(a) structure and composition

Genetics of Lipoprotein(a)

Lp(a) metabolism

Contemporary aspects of Lp(a) metabolism and therapies based on tracer kinetic methods

Role of Proprotein Convertase Subtilisin Kexin type 9 in Lipoprotein(a) Metabolism

The Role of Cell Surface Receptors in Lp(a) Metabolism

Physiological Roles And Functions Of Lipoprotein(a)

The role of Lp(a) in Atherosclerosis: An overview

Role of macrophages in Lp(a) pathophysiology

Thrombosis, Inflammation and Lipoprotein(a): Clinical Implications

The role of the kidney in Lp(a) physiology and pathophysiology

Lp(a) as a cardiovascular risk factor

Lp(a) and aortic valve stenosis, stroke, and other non-coronary cardiovascular diseases

Lp(a) in cardiovascular disease: Evidence from Large Epidemiological Studies

Lipoprotein(A) And Immunity

When to measure Lp(a)

Measurement of Lipoprotein (a) in the Clinical Laboratory

Standardization of analytical methods for the measurement of Lipoprotein(a): bridging past and future initiatives

Establishing an SI-traceable Reference Measurement System for Lp(a), based on Quantitative Protein Mass Spectrometry and Molar Units

Compounds that impact Lp(a) concentrations

Antisense oligonucleotide therapy to treat elevated lipoprotein(a)

Lipoprotein apheresis for reduction of Lipoprotein(a)

Elevated Lp(a) - Why Should I Test For It, If I Cannot Treat It? A Patient’s Perspective

Burning unanswered questions Therapy.

Notes:

Includes bibliographical references and index.

Other Format:

Print version: Kostner, Karam Lipoprotein(a)

ISBN:

3-031-24575-X