Molecular Imaging and Targeted Therapy : Radiopharmaceuticals and Clinical Applications / by Shankar Vallabhajosula.

Format:

Book

Author/Creator:

Vallabhajosula, Shankar, author.

Language:

English

Subjects (All):

Nuclear medicine.

Oncology.

Neurology.

Nuclear Medicine.

Local Subjects:

Nuclear Medicine.

Oncology.

Neurology.

Physical Description:

1 online resource (719 pages)

Edition:

2nd ed. 2023.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2023.

Summary:

This book, now published in its second edition, covers a wide range of topics relating to the use of radiopharmaceuticals. The basics of nuclear chemistry, radiochemistry, and radiopharmacology are considered in detail, regulatory issues are reviewed, and potential applications in drug development, translational medicine, clinical diagnostics, and targeted therapy are discussed. Compared with the first edition, the chapters on targeted therapy with alpha- and beta-emitting radiopharmaceuticals and theranostics are completely new. Other chapters have been updated and revised as necessary. Radioisotope-based molecular imaging probes (radiopharmaceuticals) provide unprecedented insights into biochemistry and function in both normal and diseased states of living systems, with unbiased in vivo measurements of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology, including functional magnetic resonance imaging, can provide such high sensitivity and specificity at a tracer level. This book, written by an experienced radiochemist and scientist, offers valuable insights into the full range of applications of this technology.

Contents:

Molecular Imaging and Targeted Therapy: Introduction

Atomism and Radioactivity: A Brief History

Atoms and Radiation

Radioactivity

Production of Radionuclides

PET and SPECT Scanners

Chemistry: Basic Principles

Cell and Molecular Biology

Radiopharmaceuticals

Chemistry of Organic Radionuclides (C, N, and O)

Chemistry of Radiohalogens (F, Br, I, and At)

Chemistry of Trivalent Metals Radionuclides (Ga, In, Y, Lu)

Chemistry of Transition Metals (Cu, Zr, Tc, Re)

Quality Control of Radiopharmaceuticals

Pharmacokinetics and Modeling

Molecular Imaging in Oncology

Molecular Imaging in Neurology and Psychiatry

Molecular Imaging in Cardiology

Molecular Imaging of Gene Expression and Cell Trafficking

Radiation Dosimetry and Protection

Radiopharmaceuticals for Targeted Therapy

Targeted Therapy with Beta Emitting Radiopharmaceuticals

Targeted Therapy with Alpha Emitting Radiopharmaceuticals

Theranostics: Molecular Imaging and Targeted Therapy

Radiopharmaceuticals: Drug Development and Regulatory Issues.

ISBN:

3-031-23205-4

OCLC:

1378759446