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Biomarkers in diabetes / edited by Vinood B. Patel and Victor R. Preedy.
Springer Nature - Springer Biomedical and Life Sciences eBooks 2023 English International Available online
View online- Format:
- Book
- Series:
- Biomarkers in Disease: Methods, Discoveries and Applications
- Language:
- English
- Subjects (All):
- Biochemical markers.
- Diabetes--Diagnosis.
- Diabetes.
- Physical Description:
- 1 online resource (1162 pages)
- Place of Publication:
- Cham, Switzerland : Springer, [2022]
- Summary:
- This handbook focuses specifically on biomarkers in diabetes and provides a comprehensive understanding of this field. Readers will gain deep insights into bioinformatics and network analysis of biomarkers in diabetes, and will learn about circulating biomarkers in body fluids and specific pathological features of diabetes. Various animal models in diabetes research are also presented. In addition, like the previous volumes in this large reference series, the book provides a comprehensive look at genetics, cellular, and histological variables. The goal of this handbook is to provide information on markers of this disease to facilitate diagnosis, introduce new technologies, and ultimately improve health. It is a must for researchers as well as advanced students and physicians in the field of diabetes and biomarker research and application.
- Contents:
- Intro
- Preface
- Contents
- About the Editors
- Contributors
- Part I: General Aspects
- 1 Linking Variants of Hemoglobin A1C and Glycemic Status
- Introduction
- Overview of Genome-Wide Association Studies of HbA1c
- Functional Characterization of HbA1c-Associated Genetic Variants
- Glycemic-Related Genetic Variants
- Erythrocyte-Related Genetic Variants
- Unclassified Genetic Variants
- Erythrocyte-Related HbA1c Variants and Glycemic Status Screening
- G6PD: rs1050828 and rs76723693
- HBB-rs334
- G6PD-rs1050828 and HBB-rs334
- Cumulative Effect of Erythrocyte-Related Genetic Variants
- Conclusion
- Applications to Other Diseases or Conditions
- Mini-Dictionary of Terms
- Key Facts of HbA1c
- Summary Points
- Reference
- 2 Treatment Regimes in Diabetes and Their Impact on Biomarkers
- Lipid Profile and T2DM
- Introduction to Lipids and T2DM
- The Relationship Between Obesity and Lipids
- The Relationship Between Lipids and T2DM
- Lipid Intermediates and Insulin Resistance
- Role of Exercise on Lipid Metabolism in T2DM
- Acute Effects of Exercise on Muscle Lipid Content
- Acute Effects of Exercise on Muscle Lipid Intermediates
- Chronic Effects of Exercise on Muscle Lipid Content
- Chronic Effects of Exercise on Muscle Lipid Intermediates
- Effect of Exercise on Liver Lipid Content
- Exercise Interventions and Classic Lipid Biomarkers
- Inflammatory Profile and T2DM
- Introduction to Inflammation and T2DM
- The Relationship Between Obesity and Inflammation
- The Relationship Between Inflammation and T2DM
- TNF-α and T2DM
- IL-6 and T2DM
- IL-1β and T2DM
- Anti-inflammatory Effects of Exercise
- Acute Effects of Exercise and Anti-inflammatory Mechanisms
- Chronic Effects of Exercise and Anti-inflammatory Mechanisms
- Exercise Interventions and Inflammatory Biomarkers.
- Applications to Other Diseases or Conditions
- Key Facts on Exercise and the Lipid Profile
- Key Facts on Exercise and Inflammation
- References
- Part II: Circulating and Body Fluid Biomarkers: Impact of Diabetes on Pathology
- 3 Resistin as a Biomarker and Applications to Prediabetes
- Diabetes
- Prediabetes: Definition and Related Diseases
- The Role of Adipokines at Energy Balance
- Resistin As a Biomarker at Different Types of Disease
- Resistin As a Biomarker in Cardiovascular Disorders
- Resistin As a Biomarker in Obesity
- Resistin As a Biomarker in Diabetes
- Resistin As a Biomarker in Cancer
- The Association Between Resistin and Prediabetes and Outcomes
- Key Facts of Resistin
- 4 Altered Metabolome of Amino Acids Species: A Source of Signature Early Biomarkers of T2DM
- Diabetes Mellitus
- The Need for New Biomarkers for Diabetes
- Amino Acids in Metabolic Signaling and Insulin Resistance
- Altered Amino Acid Profiles in Insulin Resistance and Diabetes
- Amino Acids Metabolic Intermediates As Markers for Insulin Resistance and Diabetes
- Conclusions
- Applications to Prognosis, Other Diseases, or Conditions
- Mini Dictionary of Terms
- Key Facts of Amino acids
- 5 Components of the Purine Metabolism Pathways as Biomarkers for the Early Diagnosis of Diabetes
- Purine Metabolism
- Xanthine Oxidase
- Adenosine Metabolizing Enzymes, Inosine and Adenosine
- Inosine-5′-Monophosphate Dehydrogenase
- Uric Acid
- Applications to Prognosis, Other Diseases or Conditions
- Key Facts of Purine Enzymes and Related Metabolites
- References.
- 6 Serpin A12 (Vaspin) as a Serine Protease Inhibitor
- Type 2 Diabetes and the Importance of Biomarkers
- Vaspin as a Diabetes Biomarker
- Biochemical Characterization
- Main Sources of Vaspin
- Vaspin and Anti-Inflammatory Effects
- Glucose Intolerance and Vaspin
- Insulin Role and Vaspin Action
- Circulating Vaspin Level, Type 2 Diabetes, and Obesity
- Metabolic Syndrome (MetS) and Vaspin
- Applications to Prognosis, Other Diseases, and Conditions
- Key Facts of Type 2 Diabetes
- 7 Advanced Glycation End Products in Diabetes
- Advanced Glycation End Products (AGEs)
- AGE Receptors
- Effects of AGEs
- AGE Measurements
- Effects of AGEs in Diabetes
- Nephropathy in Diabetes
- Cardiomyopathy and Arterial Alterations in Diabetes
- Neuropathy in Diabetes
- Retinopathy in Diabetes
- Cancer and Diabetes
- Cross Talk Between AGEs and Oxidative Stress in Diabetes
- AGEs in Other Diseases
- Key Facts of Diabetes: Where Advanced Glycation End Products Is the Topic
- 8 Markers of Liver Function and Insulin Resistance
- Applications to Diagnosis
- Summary Points (5-10)
- Markers of Liver Function and Insulin Resistance
- Visceral Fat and Insulin Resistance
- NAFLD, IR Y T2DM
- Hepatokines
- DPP4 (Dipeptidyl Peptidase-4)
- Pharmacological DPP-4 Inhibitors
- Fetuin A (AHSG)
- Fetuin B
- Selenoprotein P
- LECT-2
- Hepassocin, Also Called Hepatocyte-Derived Fibrinogen-Related Protein 1, HPS, and HFREP1
- Pigment Epithelium-Derived Factor
- Tsukushi (TSK)
- 9 Biological Markers of Insulin Sensitivity Links with Dietary Antioxidant.
- Introduction
- Key Facts of Insulin Sensitivity, Biomarkers, and Dietary Antioxidants
- Insulin Sensitivity
- Adiponectin
- Adropin, Angiopoietin-lLike Protein 4 (ANGPTL4)
- DPP4, GLP-1
- Fetuin-A and Fetuin-B
- FGF21
- HMBG1, Myostatin
- Interleukins, Irisin, RBP4
- Minerals in Insulin Resistance Sensitivity
- Calcium, Magnesium
- Chromiun, Selenium, Zinc
- Vitamins in Insulin Sensitivity
- Vitamin C, E
- Vitamin D, K, B
- 10 Serum Uric Acid and Metabolic Markers in Diabetes
- Metabolic Markers in Diabetes
- Uric Acid in Diabetes Pathophysiology
- Uric Acid as a Biomarker in Diabetes
- Serum Uric Acid as a Predictor of Diabetes Risk
- Serum Uric Acid, Blood Glucose Level, and HbA1c
- Uric Acid in Diabetic Complications
- Uric Acid in Macrovascular Complications
- Uric Acid in Microvascular Complications
- eGFR and Serum Uric Acid Levels
- Applications to Prognosis and Other Diseases or Conditions
- Applications to Prognosis
- Key Facts of Serum Uric Acid and Metabolic Markers in Diabetes: eGFR, HbA1c, and Beyond
- Key Facts of Uric Acid and Diabetes
- Key Facts of Uric Acid and Diabetic Complications
- 11 Urinary Interleukins and Kidney Damage in Diabetes
- Inflammation and Diabetic Kidney Disease
- Urinary Interleukins
- Interleukin 1
- Interleukin 6
- Interleukin 8
- Interleukin 10
- Interleukin 18
- Potential Applications to Prognosis, Other Diseases, or Conditions
- Mini-dictionary of Terms
- Key Facts of Diabetes, Kidney Damage, and Urinary Interleukins
- 12 Serum Homocysteine as a Biomarker in Diabetes
- Homocysteine and Its Role in the Body
- Biosynthesis and Metabolism of Homocysteine
- Factors Causing Hyperhomocysteinemia
- Diabetes Mellitus Cellular Metabolism Disturbance and Micronutrient Status in Diabetes Mellitus
- Hyperhomocysteinemia and Diabetes Mellitus
- Cognitive Dysfunction in Diabetes Mellitus
- Cognitive Function
- Factors That Affect Cognitive Function
- Hyperhomocysteinemia and Cognitive Function
- Compliance in Diabetes Management and Cognitive Dysfunction
- Key Facts of Serum Homocysteine as a Biomarker in Diabetes: Links with Variables Such as Cognition
- 13 3-Hydroxyisobutyrate (3-HIB): Features and Links as a Biological Marker in Diabetes
- BCAA Catabolism in Adipose Tissue
- 3-HIB in Interorgan Metabolic Crosstalk
- 3-HIB Reflects Hepatic Fatty Acid Oxidation
- Conclusion and Future Perspectives
- Key Facts of Diabetes
- 14 Proteomic Biomarkers: What They Are and How Type 2 Diabetes Mellitus Has Similarities with Other Diseases
- Proteomic Biomarkers and Type 2 Diabetes Mellitus
- Proteomics in Type 2 Diabetes Mellitus Complications
- Diabetic Retinopathy
- Diabetic Kidney Disease
- Diabetic Neuropathy and Chronic Wounds
- Proteomics in Type 2 Diabetes Mellitus and Other Diseases
- Type 2 Diabetes Mellitus and Obesity
- Type 2 Diabetes Mellitus and Cardiovascular Diseases
- Type 2 Diabetes Mellitus and Metabolic Diseases
- Type 2 Diabetes Mellitus and Pancreatic Cancer
- Type 2 Diabetes Mellitus and Neurologic Disorders
- Applications to Prognosis and Other Diseases or Conditions.
- Applications to Prognosis.
- Notes:
- Includes bibliographical references and index.
- Description based on print version record.
- Other Format:
- Print version: Patel, Vinood B. Biomarkers in Diabetes
- ISBN:
- 3-031-08014-9
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