Neurodevelopmental Pediatrics : Genetic and Environmental Influences / edited by David D. Eisenstat, Dan Goldowitz, Tim F. Oberlander, Jerome Y. Yager.

Format:

Book

Contributor:

Eisenstat, David D., editor.

Language:

English

Subjects (All):

Pediatrics.

Neurology.

Medical genetics.

Medical Genetics.

Local Subjects:

Pediatrics.

Neurology.

Medical Genetics.

Physical Description:

1 online resource (1013 pages) : illustrations (black and white, and color).

Edition:

1st ed. 2023.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2023.

Summary:

This book explores the interrelationship of genetics, the environment, or both, in the causation of three neurodevelopmental disorders: autism/autism spectrum disorder (ASD), fetal alcohol spectrum disorder (FASD), and cerebral palsy (CP). It links common clinical problems in developmental pediatrics and pediatric neurology to current concepts and translational research advances in developmental neurosciences, medical genetics, and related disciplines. The first section of the book provides a comprehensive and up-to-date overview of development of the brain, including topics such as neuronal stem cells, epigenetics, and the influence of the prenatal environment. The next three sections analyze the epidemiology, diagnosis, interventions, and controversies and research directions associated with each of the three neurodevelopmental disorders. It also examines co-morbidities common to all three disorders, such as disturbed sleep, seizures, behavioral disorders, and pain. It concludes by highlighting the impact of ASD, FASD, and CP on family dynamics and provides tools and resources based on foundational concepts such as neuroethics, bioinformatics, community engagement, and advocacy. Learning objectives, key points, clinical vignettes, and multiple choice questions are incorporated throughout the book. With its comprehensive treatment of disease mechanisms, genetics, and pathophysiology associated with these disorders and its discussion of potential therapies and novel treatments, Neurodevelopmental Pediatrics: Genetic and Environmental Influences is an essential resource for developmental pediatricians, child neurologists, fellows, residents and graduate students.

Contents:

PART I : OVERVIEW OF CNS DEVELOPMENT AND DISORDERS

1. Overview of CNS Organization and Development

2. Neural Induction and Regionalization

3. Neural Stem Cells, Differentiation, and Migration

4. Neurotrophins and Cell Death

5. Synaptogenesis

6. Axonal Guidance

7. Myelination

8. Epigenetics

9. The Impact of An Adverse Intrauterine Environment on Neurodevelopment

10. Stress as a Determinant of Neurodevelopmental Outcomes

11. Sex differences in Neurodevelopment and its Disorders

PART II : AUTISM SPECTRUM DISORDERS

12. The History of Autism Spectrum Disorder

13. Epidemiology

14. An Approach to the Diagnosis of Autism Spectrum

15. Cognition

16. The Neuroradiology of Autism: Framing neuroimaging investigations of the autistic brain based on the US NIMH Research Domain Criteria

17. Neuropathology of Autism

18. Genetics and Epigenetics of ASD

19. Preclinical Models of Autism Spectrum Disorder

20. Biomedical Interventions for Autism Spectrum Disorder

21. Interventions in ASD – Psychosocial Interventions for ASD

PART III : FETAL ALCOHOL SPECTRUM DISORDER

22. Clinical Perspectives on the Diagnostic Assessment of Individuals with FASD

23. Epidemiology of alcohol consumption among pregnant and childbearing age women and Fetal Alcohol Spectrum Disorder

24. Diagnosis

25. Magnetic Resonance Imaging in Fetal Alcohol Spectrum Disorder (FASD)

26. Neuropathological changes in humans with history of prenatal alcohol exposure or diagnosis of fetal alcohol spectrum disorder

27. Genetics and Epigenetics of FASD

28. Genetic, Epigenetic, and Environmental Influences on Fetal Alcohol Spectrum Disorder: Implications for Diagnosis, Research and Clinical Practice

29. Interventions

PART IV : CEREBRAL PALSY

30. Clinical Vignettes

31. Epidemiology

32. Diagnosis

33. Neuroradiology Of Cerebral Palsy

34. Neuropathology Of “Cerebral Palsy”

35. Genetics and Genomics of Cerebral Palsy

36. Pre-Clinical Models of Cerebral Palsy

37. Therapeutic Approaches for the Treatment of Cerebral Palsy and Developmental Disability

PART V : CO-MORBIDITIES IN NEURODEVELOPMENTAL DISORDERS

38. Sleep Disorders

39. Optimizing Therapy of Seizures in Children and Adolescents with Developmental Disabilities

40. Behavioral and Mental Health Disorders (including Attentional Disorders)

41. Role of Gender and Neurodevelopmental Disabilities

42. A non‐categorical approach to childhood neurodisability: concepts, evidence and implications for clinical practice, organization of services, teaching, and research

43. Pain and Symptom Management in Neurodevelopmental Disorders: Sensory and Nociceptive Function/Pain and Symptom Management

44. Pharmacology, Psychopharmacology and Adverse Drug Reactions

45. Developmental origins, differential susceptibility and resilience in neurodevelopmental disorders

PART VI : NEURODEVELOPOMENTAL DISORDERS IN THE CONTEXT OF FAMILIES

46. Children with Neurodevelopmental Disabilitiesand the Right to Health

47. Patient Navigation: Core Concepts and Relevance to the Field of Pediatric Neurodisability

48. Evaluating the Economic Impact of Neurodevelopmental Disability Intervention on the Family and Community

PART VII : RESOURCES

49. Using Large-Scale Population-Based Data

50. Tools for Knowledge Dissemination and Translation to help your journey from research to impact.

Notes:

Includes bibliographical references and index.

Other Format:

Print version: Eisenstat, David D. Neurodevelopmental Pediatrics

ISBN:

3-031-20792-0

OCLC:

1371587570