Translational surgery / edited by Adam E.M. Eltorai, Jeffrey A. Bakal, Paige C. Newell, Adena J. Osband

Format:

Book

Contributor:

Eltorai, Adam E. M., editor.

Bakal, Jeffrey A., 1975- editor.

Newell, Paige C., editor.

Osband, Adena J., editor.

Series:

Handbook for designing and conducting clinical and translational research

Language:

English

Subjects (All):

Surgery, Experimental.

Physical Description:

1 online resource

Place of Publication:

London : Academic Press, [2023]

Summary:

"Translational Surgery covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. The reader will come to fully understand important concepts including case-control studies, prospective cohort studies, randomized trials, and reliability studies. Investigators will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in surgical research, and know what is needed for collaboration. Further, this title is an indispensable tool in grant writing and funding efforts. The practical, straightforward approach helps the translational research navigate challenging considerations in study design and implementation. The book provides valuable discussions of the critical appraisal of published studies in surgery, allowing the reader to learn how to evaluate the quality of such studies. Thus, they will improve at measuring outcomes; making effective use of all types of evidence in patient care. In short, this practical guidebook will be of interest to every surgeon or surgical researcher who has ever had a good clinical idea, but not the knowledge of how to test it"-- From ScienceDirect

Contents:

Introduction / Ivy N. Haskins

Translational research process / Temilolaoluwa O. Daramola and Aderinsola A. Aderonmu

Scientific method / Ashley C. Dodd, Benjamin R. Zambetti and Jeremiah Deneve

Basic Research / Ruby Gilmor, Hashir Qamar and Nicholas Huerta

Overview of preclinical research / Laura M. Fluke

What problem are you solving? / Erfan Faridmoayer, Abbasali Badami, F. Charles Brunicardi

Types of intervention / Haley A. Zlomke, Erin M. Scott and Richard A. Burkhart

Drug discovery and development / Rohan Palanki and Sourav K. Bose

Drug testing : translating a novel immunotherapeutic from bench to bedside / Kirit Singh, John H. Sampson and Patrick C. Gedeon

Device discovery and prototyping / Seiji Yamaguchi and Ali Seifi

Medical device testing : a neurosurgical perspective / Kashif Majeed and Javed Khader Eliyas

Diagnostic discovery / Kevin L. Smith, Megan LeBlanc and Mohan Ramalingam

Diagnostic testing / Precious Idorenyin Anthony

FDA regulating power & guidelines : other product types / Temilolaoluwa O. Daramola and Aderinsola A. Aderonmu

Procedural technique development / Brandon M. White and Sourav K. Bose

Behavioral Interventions / Megan LeBlanc, Kevin L. Smith and Mohan Ramalingam

Introduction to clinical research : What is it? Why is it needed? / Jacob Levy, Jenna Maroney and Mohammed A. Kashem

The question : types of research questions and how to develop them / Lauren L. Beck

Study population : Who and why them? / Kaitlin A. Nguyen, Clay Resweber and Sunil S. Karhadkar

Outcome measurements : What data are being collected and why? / Houston Curtis, Juliet Panichella and Sunil S. Karhadkar

Optimizing the question : balancing significance and feasibility / Kathryn C. Kelley

Basic statistical principles / Ravali Yenduri and Rachel E. Silver

Distributions / Mala Sachdev, Andrew Vierra and Athena Andreadis

Hypothesis and error types / Karuna Dewan

Power / Christina Poa-Li, Saleh Aiyash and Gabriel Akopian

Regression analysis / Afif N. Kulaylat, Linh Tran, Christopher S. Hollenbeak

Continuous variable analyses / Andrew Vierra, Abdul Razzaq and Athena Andreadis

Categorical Variable Analyses / Andrew Vierra, Abdul Razzaq and Athena Andreadis

Analysis of variance / Kaci DeJarnette and Madhu Mamidala

Correlation / Faique Rahman, Ahmad Ozair, Abhinav Arun Sonkar

Biases in research studies / Fernando D. Arias, Matthew Navarro, Omar Elfanagely

Basic science statistics / Ruben D. Salas-Parra, Kenny J. Castro-Ochoa and David A. Machado-Aranda

Design principles : hierarchy of study types / Qingwen Kawaji, David Blitzer, David E. Stein

Case series : design, measures, and classic example / Qingwen Kawaji, David Blitzer, Jason Crowner

Case-control study—design, measures, and classic examples / Shane Charles, Israel Dowlat

Cohort study : design, measures, and classic examples / Shane Charles, Israel Dowlat

Cross-sectional study : design, measures, classic examples / Tiffany R. Sanchez, Yaritza Inostroza-Nieves, Wendy Chen

Longitudinal study : design, measures, and classic example / Angel D. Chavez-Rivera, Yaritza Inostroza-Nieves, Wendy Chen

Designing clinical trials of surgical interventions / Gerald M. Bowers, Hector Mejia, Juan Duchesne

Meta-analysis / Arad Abadi, Charissa Kim, Gabriel Akopian

Cost-effectiveness research / Jessica Dominique Feliz, Louis L. Nguyen

Diagnostic test evaluation : design, measures, and classic example / Jacqueline L. Russell, Matthew A. Brown, Jeffrey W. Shupp

Reliability study : design, measures, and classic example / Tandis Soltani, Jason M. Flynn, Juan Cendan

Database research / Jessica Dominique Feliz, Mohamad A. Hussain

Surveys and questionnaires : design, measures, and classic examples / Samuel M. Manstein, Eric Shiah, Elizabeth Laikhter

Qualitative methods and mixed methods / Vanessa M. Welten, Amanda J. Reich

Randomized control : design, measures, and classic examples / Andrew Vierra, Abdul Razzaq, Athena Andreadis

Nonrandomized control : design, measures, classic example / Tiffany R. Sanchez, Angel D. Chavez-Rivera, Delia S. Ocaña Narváez

Historical controls / Jody C. DiGiacomo

Cross-over : design, measures, classic example / Angel D. Chavez-Rivera, Tiffany R. Sanchez, Delia S. Ocaña Narváez

Withdrawal studies : design, measures, and classic examples / Lauren L. Beck

Factorial design : design, measures, and classic examples / Alexandra M. Adams, Patrick M. McCarthy, Daniel W. Nelson

Group allocation / Matthew T. Hey, Hans E. Drawbert, Syed S. Razi

Hybrid design / Youssef Aref, Christina Shree Chopra, Samuel Lance

Large, pragmatic trials : designs, measures and classic examples / Saptarshi Biswas, Heather X. Rhodes, Christa Zino

Equivalence and noninferiority / Philip McCarthy, Benjamin Acton, Jessica Maxwell

Adaptive : design, measures, and classic examples / Patrick M. McCarthy, Alexandra M. Adams, G. Travis Clifton

Principles and methods of randomization in research / Kathryn L. Fowler, Martin D. Fleming

Blinding : who and how? / Taylor Anderson, Susan Rowell

Multicenter considerations / Erin M. Scott, Haley A. Zlomke, Nicole B. Cherng

Registries / Jeffrey Alexander Bakal, Sean C. Stuart

Phases of clinical trials / Ahmad Ozair, Vivek Bhat, Anil Nanda

IDEAL framework / James M. Dittman, Michael F. Amendola

Artificial intelligence methodology in clinical research / Sangeetha Prabhakaran, Hyo Jung Hong

Patient perspectives / Christina Shree Chopra, Ersilia Anghel, Allison Nauta

Sample size / Jordan C. Apfeld, Jane R. Schubart, Afif N. Kulaylat

Budgeting / Aminah Abdul Razzack, Nirmit Patel, Aneri Patel

Medical ethics and review boards / Dennis Spalla Morris, Andrea Valquiria Sanchez

Regulatory considerations for new drugs and devices / Haley Nadone, Christian Gonzalez, Mark Riddle

Funding approaches / Peter Oro, Gehan A. Pendlebury, Kate Whelihan

Subject recruitment / Christina Shree Chopra, Ersilia Anghel, Allison Nauta

Data management / Julie Goldman, Hao Wei Chen, Jaime Pardo Palau

Quality control / Varun V. Bansal, Tushar Garg, Monty U. Khajanchi

Statistical software / Chan Shen, Roger Klein, Afif N. Kulaylat

Case report forms : harm and quality of life / Favour Mfonobong Anthony

Subject adherence / Gehan A. Pendlebury, Peter Oro, Kate Whelihan

Survival analysis / Andrew Vierra, Miguel Garcia, Athena Andreadis

Monitoring committees in clinical trials / Ahmad Ozair, Vivek Bhat, Anil Nanda

FDA overview / Deacon J. Lile

Investigational new drugs / Patrick M. McCarthy, Alexandra M. Adams, G. Travis Clifton

Drug development / Dallas J. Soyland, Katherine Nielson, Tayt Boeckholt

Devices / Mackinzie A. Stanley, Carol A. Lin

Regulatory basics : radiation-emitting electronic medical products / Syed Faraz Kazim, Javed Khader Eliyas

Orphan drugs / Pallavi Menon, Rohan Palanki, Sourav K. Bose

Biopharmaceuticals / Serena Dasani, Rohan Palanki, Sourav K. Bose

Combination products / Andrew L. DiMatteo, Jessica Barson, Ramesh Raghupathi

Foods / J. Barney, M. Campbell, Adena J. Osband

Cosmetics / J. Barney, M. Campbell, Adena J. Osband

Non-US regulatory / Andrew Yiu, Nizam Mamode

Implementation research / James C. Etheridge, Robert D. Sinyard, Mary E. Brindle

Design and analysis / Kashif Majeed, Javed Khader Eliyas

Population- and setting-specific implementation / Quynh Kieu, Jennifer L. Byk, Andrew R. Bender

Public health / David Lee, Kevin Chen, Jessica S. Kruger

Epidemiology / Christina Shree Chopra, Matthew Handmacher, Christopher Reid

Factors in surgical public health and health disparities research / Benjamin G. Allar, Chukwuma N. Eruchalu, Gezzer Ortega

Good questions in public health research / Benjamin G. Allar, Emily E. Witt, Gezzer Ortega

Population and environmental specific considerations / Christina Shree Chopra, Aria Darbandi, Christopher Reid

Law, policy, and ethics / Deacon J. Lile

The role of healthcare institutions in translational surgical research / Gerald M. Bowers, Darren C. Cheng, Marc J. Kahn

Public health institutions and systems / Vanessa Roxo, Ali Salim

Data presentation / Danilea M. Carmona Matos, Rachael E. Guenter, Herbert Chen

Manuscript preparation : an overview for authors / Rebecca L. Williams-Karnesky, Audrey S. Kulaylat, Afif N. Kulaylat

Building a team / Mehida Rojas-Alexandre

Patent basics / Xinyi Luo, Carl Haupt, John S. Bolton

Venture pathways / Abhishek Mane, Panini Patankar, Varun V. Bansal

Small business innovation research and small business technology transfer / Tsering Y. Dirkhipa, Varun V. Bansal, Rakesh Ahuja

Sample forms and templates / Christina Shree Chopra, Daniel C. Neubauer, Samuel Lance

Notes:

Includes bibliographical references and index

Online resource; title from PDF title page (ScienceDirect, viewed August 11, 2025)

Other Format:

Print version: Translational surgery

ISBN:

0323906303

9780323906302

OCLC:

1373980856

Access Restriction:

Restricted for use by site license