Handbook of developmental neurotoxicology / edited by William Slikker Jr., Merle G. Paule, Cheng Wang.

Format:

Book

Contributor:

Slikker, William Jr, editor.

Paule, Merle G., editor.

Wang, Cheng, editor.

Language:

English

Subjects (All):

Neurotoxicology--Handbooks, manuals, etc.

Neurotoxicology.

Physical Description:

1 online resource (xvii, 598 pages) : illustrations, charts

Edition:

Second edition.

Place of Publication:

London : Academic Press, [2018]

Summary:

Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in the field, bridging developmental neuroscience with the principles of neurotoxicology. The book features eight new chapters with newly recruited authors, making it an essential text for students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience.- Presents a comprehensive, up-to-date resource on developmental neurotoxicology with updated chapters from the first edition- Contains new chapters that focus on subjects recent to the field- Includes well-illustrated material, with diagrams, charts, and tables- Contains compelling case studies and chapters written by world experts

Contents:

Cover

Title page

Copyright page

Contents

List of Contributors

Preface and Acknowledgments

Part I - Cellular and molecular morphogenesis of the nervous system

Chapter 1 - Brain Morphogenesis and Developmental Neurotoxicology

I - Introduction

II - Marr proposed computational models be integrated over three levels

III - Morphogenetic features emerge from interactions across multiple levels of biological organization

A - Sensory Pathways Encode Features of Sense Organs and the Environment

B - Neurovascular Coupling (NVC) is Essential to Brain Connectivity

C - Engrams Exist at Multiple Structural Levels

IV - Whole Brain Assessment of Larval Zebrafish Reveals Patterns of Connectivity

V - Conclusions: morphology informs predictive models of developmental neurotoxicity

Acknowledgments

Abbreviations

References

Further Reading

Chapter 2 - Neural Cell Adhesion Molecules in Normal and Abnormal Neural Development

II - The expression levels of NCAM and PSA-NCAM during the development

III - Regulating PSA-NCAM expression and cell migration

IV - Requirement of PSA-NCAM for activity-induced synaptic plasticity

Chapter 3 - Neurite Development and Neurotoxicity

A - Molecular Mechanisms Underlying Neurite Growth

1 - Applications in Neurotoxicology: Addressing Molecular Mechanisms

B - Genetic Modulation of Neurite Development

1 - Examples of Genetic Modulation by Neurotoxicants

C - Cell Death Mechanisms and Neurite Development

1 - Relevance to Neurotoxicology: Addressing Cell Death Mechanisms

D - Stem/Progenitor Cells and Neurite Development

1 - Applications of Stem Cell Technology for Neurotoxicology

E - Neurite Growth and State-of-the-Art Techniques

1 - Overview

2 - High-Content Imaging.

3 - Applications Using HCI

4 - Three-Dimensional Approaches

a - Organotypic Culture Technique for Assessing Neurite Growth

b - 3D Cell Culture

5 - Nanotechnology and Neurite Development

a - Applications of Nanotechnology

b - Neurotoxicity of Nanomaterials

6 - Bioengineering and Neurite Development

a - De Novo Measurement of Neurite Growth

b - Bioengineering-Induced Neurotoxicity Related to Neurite Development

II - Conclusions

Acknowledgment

Chapter 4 - Myelin: Structure, Function, Pathology, and Targeted Therapeutics

II - Myelin architecture and assembly: old and new perspectives

A - Traditional View of Myelin

B - Recent Findings: Myelin Structure and Functions

III - Neuron-glia communication and its regulation

IV - Myelinating glial cell lineages in peripheral and central nervous systems

A - Schwann Cells

B - Oligodendrocytes

V - Chemical composition of vertebrate myelin

VI - Dysmyelination: myelin mutant models for dysmyelination

VII - Demyelination: effect of various factors on developmental myelination

A - Malnutrition

B - Thyroid Deficiency

VIII - Remyelination and CNS disorders: myelin to axonal regeneration

IX - Newer treatment strategies for myelin disorders

X - Conclusions

Part II - Developmental neurobiology/toxicology

Chapter 5 - Neurotrophic Factors

I - Neurotrophic factors

II - Expression pattern and regulation

III - Neurotrophin receptors

IV - Neurotrophic factors in cell survival and cell death

V - Neurotrophins and synaptic plasticity

VI - Neurotrophins and behavior

VII - Other neurotrophic factors

VIII - Clinical correlates to neurodegenerative disorders

IX - Clinical correlates to psychiatric disorders

X - Genetic polymorphisms.

XI - Neurotrophins as therapeutic agents

Chapter 6 - Serotonin Signaling as a Target for Craniofacial Embryotoxicity

I - Introduction-Serotonin and Embryonic Development

II - Serotonin signal transduction

A - Serotonin Release and Selective Serotonin Reuptake Inhibitors

B - Serotonin Receptors and Receptor Antagonists

III - Role of serotonin in development

A - Placental Transfer of Serotonin

B - Serotonin and Craniofacial Development

C - Embryonic Precursors of the Facial Skeleton

D - Serotonin and Neural Crest Cells

E - Importance of Proper Orofacial Osteogenesis to Orofacial Development

F - Serotonin and Bone Development

IV - Conclusions

Chapter 7 - Neurotoxic and Neurotrophic Effects of GABAergic Agents on the Developing Brain

II - The GABAergic system during development

III - GABAergic agents and consequences of perturbations of GABAergic system development

IV - Animal models of GABAergic system perturbation

V - In vitro and cell-based models of GABAergic system perturbation during neurodevelopment

VI - Bioinformatic and computational approaches

VII - Protecting the developing GABAergic system: prospects for the future

Chapter 8 - Neural Stem Cell Biology and Application to Developmental Neurotoxicity Assessment

I - Neural stem cells in the developing brain

II - Neural stem cells in the adult brain

III - NSCs-derived from embryonic stem cells and induced pluripotent stem cells

IV - Application of NSCs to developmental neurotoxicity assessments

A - Status of Developmental Neurotoxicity Tests

B - Considerations on the Utilization of NSCs as an In Vitro Model for DNT Assessment

V - Conclusions

Further Reading.

Chapter 9 - Apoptosis as a Mechanism of Developmental Neurotoxicity

II - Molecular Mechanisms of Apoptosis in the Developing Nervous System

III - Physiological Roles of Apoptosis in Neurodevelopment

IV - Chemical-Induced Apoptosis

A - Anesthetics

B - Polychlorinated Biphenyls

C - Zinc

Chapter 10 - Periods of Susceptibility: Interspecies Comparison of Developmental Milestones During Ontogenesis of the Central Ne...

II - Overview of central nervous system development

A - Neural Tube Formation

B - Cellular Components of the Neural Plate

C - Primary Neurulation

D - Formation of Cerebral Vesicles

E - Secondary Neurulation

F - Intramural Development and Nuclei

III - Developmental milestones

A - Externally Observed Central Nervous System Developmental Milestones

B - Internally Observed Central Nervous System Developmental Milestones

C - Developmental Milestones Related to Myelination

D - Developmental Milestones of Cerebral Cortex

Chapter 11 - Modeling the Neurovascular Unit In Vitro and In Silico

II - Animal models of BBB development and function

III - Cell-based models

IV - Static three-dimensional (3D) models

V - Organotypic culture models (OCMs) and microphysiological systems(MPS)

VI - Implementing in vitro BBB models for DNT

VII - In silico models: BBB permeability

VIII - In silico models: virtual NVU

IX - Summary and conclusions

Chapter 12 - Zebrafish as a Model for Developmental Biology and Toxicology

II - Developmental biology

A - Gastrulation

B - Organogenesis

C - Neurodevelopment

D - Neurulation

E - Neurogenesis

F - Eye

G - Brain.

H - Behavior

III - Developmental toxicology

A - Assessments and Chemicals Screened

1 - Fish Embryo Acute Toxicity (FET) Test

2 - Morphological Screens

3 - Behavioral Assays

B - Advancements

IV - Concordance with mammalian models

Chapter 13 - Using Caenorhabditis elegans to Study Neurotoxicity

II - Studies of specific neurotoxins

A - Manganese

B - Selenium

C - Methylmercury

D - Other Toxins

III - Anesthetic-induced neurotoxicity

Part III - Synaptogenesis and neurotransmission

Chapter 14 - Human 3D In Vitro Models for Developmental Neurotoxicity

I - Developmental neurotoxicity represents a societal testing need

II - The current testing approach for DNT in vivo and in vitro does not satisfy our needs

III - The process of developing in vitro strategies for DNT

IV - The development of a reproducible BMPS for modeling neurodevelopment and testing its perturbation

V - Ongoing developments of the mini-brain

VI - Conclusions

Chapter 15 - Ontogeny of Monoamine Neurotransmitters

II - Innervation of terminal fields

A - Ontogeny of Dopaminergic Innervation

B - Ontogeny of Noradrenergic Innervation

C - Ontogeny of Serotonergic Innervation

III - Neurochemical synaptogenesis

A - Neurotransmitter Content

1 - Dopamine

2 - Norepinephrine

3 - Serotonin

B - Biosynthetic Enzymes

1 - Tyrosine Hydroxylase

2 - Dopamine β-Hydroxylase (DβH)

3 - Tryptophan Hydroxylase (TPH)

C - Reuptake Systems

1 - High-Affinity DA Uptake

2 - High-Affinity NE Uptake

3 - High-Affinity 5-HT Uptake

D - Monoaminergic Receptors

1 - Dopaminergic Receptors

2 - Noradrenergic Receptors

3 - Serotonergic Receptors.

a - Developmental neurotoxicity of amphetamine-type stimulants.

Notes:

Includes bibliographical references and indexes.

Description based on print version of record.

ISBN:

0-12-809394-3