Gene therapy of cancer : translational approaches from preclinical studies to clinical implementation / edited by Edmund C. Lattime, Stanton L. Gerson.

Format:

Book

Contributor:

Lattime, Edmund C., 1951-

Gerson, Stanton L.

Language:

English

Subjects (All):

Cancer--Gene therapy.

Cancer.

Cancer--Immunotherapy.

Physical Description:

1 online resource (555 p.)

Edition:

2nd ed.

Place of Publication:

San Diego, CA : Academic Press, c2002.

Language Note:

English

Summary:

The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable re

Contents:

Front Cover; Gene Therapy of Cancer; Copyright Page; Contents; Contributors; Preface; PART I: VECTORS FOR GENE THERAPY OF CANCER; Chapter 1. Retroviral Vector Design for Cancer Gene Therapy; I. Introduction; II. Applications for Retroviral Vectors in Oncology; III. Biology of Retroviruses; IV. Principles of Retroviral Vector Systems; V. Advances in Retroviral Vector Tailoring; VI. Outlook; References; Chapter 2. Noninfectious Gene Transfer and Expression Systems for Cancer Gene Therapy; I. Introduction; II. Advantages and Disadvantages of Infectious, Viral-Based Vectors for Human Gene Therapy

III. Rationale for Considering Noninfectious, Plasmid-Based Expression SystemsIV. Gene Transfer Technologies for Plasmid-Based Vectors: Preclinical Models and Clinical Cancer Gene Therapy Trials; V. Plasmid Expression Vectors; VI. Future Directions; References; Chapter 3. Parvovirus Vectors for the Gene Therapy of Cancer; I. Introduction; II. Biology of Parvoviridae and Vector Development; III. Applications of Recombinant Parvovirus Vectors to Cancer Gene Therapy; IV. Perspectives, Problems, and Future Considerations References; References; Chapter 4. Antibody-Targeted Gene Therapy

I. IntroductionII. Background: Monoclonal Antibodies and Cancer Therapy; III. Recent Advances: Monoclonal-Antibody-Mediated Targeting and Cancer Gene Therapy; IV. Future Directions; References; Chapter 5. Ribozymes in Cancer Gene Therapy; I. Introduction; II. Ribozyme Structures and Functions; III. Cancer Disease Models for Ribozyme Application; IV. Challenges and Future Directions; References; Chapter 6. The Advent of Lentiviral Vectors: Prospects for Cancer Therapy; I. Introduction; II. Structure and Function of Lentiviruses

III. Features that Distinguish Lentiviral from Oncoretroviral VectorsIV. Manufacture of Lentiviral Vectors; V. Possible Applications of Lentiviral Vectors in Cancer Therapy; VI. Conclusions; References; PART II: IMMUNE TARGETED GENE THERAPY; Chapter 7. Immunologic Targets for the Gene Therapy of Cancer; I. Introduction; II. Cellular (T-Lymphocyte-Mediated) Versus Humoral (Antibody-Mediated) Immune Responses to Tumor Cells; III. Response of CD4+ and CD8+ T Lymphocytes to Tumor Antigens Presented in the Context of Molecules Encoded by the Major Histocompatibility Complex

IV. Response of Tumor-Bearing Individuals to Tumor AntigensV. Tumor-Associated Peptides as Candidate Targets for Tumor-Specific Lymphocytes; VI. Immunotherapeutic Strategies for the Treatment of Cancer; VII.Conclusions; References; PART IIa: VACCINE STRATEGIES; Chapter 8. Development of Epitope-Specific Immunotherapies for Human Malignancies and Premalignant Lesions Expressing Mutated ras Genes; I. Introduction; II. Cellular Immune Response and Antigen Recognition; III. Pathways of Antigen Processing, Presentation, and Epitope Expression; IV. T-Lymphocyte Subsets

V. ras Oncogenes in Neoplastic Development

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-281-00542-8

9786611005429

0-08-049136-7

OCLC:

476059715