The Essential Guide to N-of-1 Trials in Health / edited by Jane Nikles, Geoffrey Mitchell.

Format:

Book

Contributor:

Nikles, Jane., Editor.

Mitchell, Geoffrey., Editor.

Language:

English

Subjects (All):

Medicine.

Chemotherapy.

Psychology.

Statistics.

Pharmacy.

Biomedicine, general.

Pharmacotherapy.

Psychology, general.

Statistics for Life Sciences, Medicine, Health Sciences.

Local Subjects:

Biomedicine, general.

Pharmacotherapy.

Psychology, general.

Statistics for Life Sciences, Medicine, Health Sciences.

Pharmacy.

Physical Description:

1 online resource (245 p.)

Edition:

1st ed. 2015.

Place of Publication:

Dordrecht : Springer Netherlands : Imprint: Springer, 2015.

Language Note:

English

Summary:

N-of-1 trials, a type of individualized randomized controlled trial, are relevant to almost every discipline in medicine and psychology. They can tell the clinician with precision whether a treatment works in that individual, which distinguishes from the information available from most other trial designs. They have the potential to revolutionize the way clinical medicine is practiced. Whether you are a busy clinician, a researcher or a student, this book provides everything you need to know about N-of-1 trials. Written and edited by some of the world’s leading experts on N-of-1 trials, the book presents state of the art knowledge about N-of-1 trials, with chapters on ethics, statistics, health economics, design, analysis and reporting, and more. Full of examples and well illustrated, it is a comprehensive compendium of issues surrounding the design, conduct, interpretation and implementation of N-of-1 trials in a health system.

Contents:

Preface

Introduction

What are N-of-1 trials?- N-of-1 trials in the behavioural sciences

N-of-1 trials in medical contexts

Aggregated N-of-1 trials

Methodological considerations for N-of-1 trials

Randomization, allocation concealment and blinding

Data collection and quality control

Individual reporting of N-of-1 trials to patients and clinicians

Assessing and reporting adverse events

Research ethics and N-of-1 trials

Statistical analysis of N-of-1 trials

The economics of N-of-1 trials

Reporting N-of-1 trials to professional audiences

Single patient open trials

Systematic review and meta-analysis using N-of-1 trials

Where are N-of-1 trials headed?- Index.

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

ISBN:

94-017-7200-2