4 options
Modeling the psychopathological dimensions of schizophrenia : from molecules to behavior / edited by Mikhail V. Pletnikov, Johns Hopkins University School of Medicine, Baltimore, MD, USA, John L. Waddington, Royal College of Surgeons in Ireland, Dublin, Ireland.
- Format:
- Book
- Series:
- Handbook of behavioral neuroscience ; v. 23.
- Handbook of behavioral neuroscience ; volume 23
- Language:
- English
- Subjects (All):
- Schizophrenia--Handbooks, manuals, etc.
- Schizophrenia.
- Schizophrenia--Physiological aspects--Handbooks, manuals, etc.
- Psychology, Pathological--Handbooks, manuals, etc.
- Psychology, Pathological.
- Disease Models, Animal.
- Medical Subjects:
- Schizophrenia.
- Disease Models, Animal.
- Physical Description:
- 1 online resource (550 p.)
- Edition:
- 1st ed.
- Place of Publication:
- Boston, MA : Elsevier, [2016]
- Language Note:
- English
- Summary:
- Modeling the Psychopathological Dimensions of Schizophrenia: From Molecules to Behavior is the first book to offer a comprehensive review of the new theoretical, clinical, and basic research framework that considers psychotic illness as a group of dimensional representations of psychopathology rather than as traditional distinct categorical.
- Contents:
- Front Cover; MODELING THE PSYCHOPATHOLOGICAL DIMENSIONS OF SCHIZOPHRENIA: FROM MOLECULES TO BEHAVIOR; Copyright; Contents; Contributors; Preface; I - FROM MOLECULES TO BEHAVIOR; Clinical and Pathological Aspects; 1 - Overview of Schizophrenia: Dimensions of Psychopathology; THE INADEQUACY OF DIAGNOSTIC CATEGORIES; PSYCHOPATHOLOGICAL DIMENSIONS-A CHALLENGE TO CATEGORICAL APPROACH TO DIAGNOSIS; THE NEED FOR A PRECISE DIMENSIONAL MODEL; SPECIFICITY TO DISORDER; CHRONOLOGICAL STABILITY OF DIMENSIONS; DIFFERENTIAL ASSOCIATIONS OF DIMENSIONS WITH BIOLOGICAL AND CLINICAL PARAMETERS
- CATEGORIES OR DIMENSIONS, OR BOTH?CONCLUSION; References; 2 - A Review of the Epidemiology of Schizophrenia; INTRODUCTION; EVIDENCE FOR ENVIRONMENTAL FACTORS IN SCHIZOPHRENIA; Prenatal Infection; Influenza; Rubella; Herpes Simplex Virus Type 2; Cytokines and Other Inflammatory Biomarkers; Toxoplasma gondii; Maternal Infection and the Pathobiology of Schizophrenia; Prenatal Nutrition; Paternal Age; Cannabis Use; Immigration Status; Birthplace and Residence; Socioeconomic Status; Childhood Abuse; INFECTIONS AFTER BIRTH; GENE-ENVIRONMENT INTERACTION; Intervention and Prevention
- FUTURE DIRECTIONSCONCLUSION; References; Animal Models of Psychotic Disorders: Dimensional Approach; 3 - Modeling Dimensions of Psychopathology: Integration with the Epidemiology and Pathobiology of Psychotic Illness; INTRODUCTION; MODELING DIMENSIONS OF PSYCHOPATHOLOGY; MODELING DIMENSIONS OF PSYCHOPATHOLOGY IN THE CONTEXT OF THE EPIDEMIOLOGY OF PSYCHOTIC ILLNESS; MODELING DIMENSIONS OF PSYCHOPATHOLOGY IN THE CONTEXT OF THE PATHOBIOLOGY OF PSYCHOTIC ILLNESS; CONCLUSIONS; Acknowledgments; References; 4 - Modeling the Positive Symptoms of Schizophrenia; INTRODUCTION
- DELUSIONS AND HALLUCINATIONSDelusions; Hallucinations; Visual Hallucinations; Auditory Hallucinations; NEUROIMAGING STUDIES ON POSITIVE SYMPTOMS; Brain Structures; Brain Regional Activity and Connectivity; DELUSIONAL AND HALLUCINOGENIC SIGNALING; Dopamine Signaling through Dopamine D2 Receptors; Serotonin Signaling through Serotonin 2A Receptors; Cannabinoid Signaling through CB-1 Receptors; Cholinergic Signaling through Muscarinic Receptors; Gamma-Aminobutyric Acid A Signaling through Gamma-Aminobutyric Acid A Receptors; Glutamate Signaling through NMDAR
- METHODS TO INVESTIGATE POSITIVE SYMPTOM-RELATED BEHAVIORS IN ANIMAL MODELSPrepulse Inhibition of Startle Response; Locomotor Activity; Head-Twitch Response; Y-Maze Test and Water-Finding Test; Cued and Contextual Fear Conditioning; CONCLUSION; References; 5 - Animal Models of Psychotic Disorders: Dimensional Approach Modeling Negative Symptoms; INTRODUCTION; MODELING SYMPTOMATOLOGY; MODEL VALIDITY; MODELING TECHNIQUES; MODELING THE NEGATIVE SYMPTOMS; Anhedonia; Avolition; Social Withdrawal; Alogia; Blunted Affect; CONCLUSIONS; References; 6 - Modeling Cognitive Impairment
- COGNITIVE DYSFUNCTIONS IN SCHIZOPHRENIA AND MOUSE MODELS
- Notes:
- Description based upon print version of record.
- Includes bibliographical references and index.
- Description based on print version record.
- Description based on publisher supplied metadata and other sources.
- ISBN:
- 0-12-800981-0
- 0-12-801184-X
- OCLC:
- 936300189
The Penn Libraries is committed to describing library materials using current, accurate, and responsible language. If you discover outdated or inaccurate language, please fill out this feedback form to report it and suggest alternative language.