Advances in animal alternatives for safety and efficacy testing / edited by Harry Salem, Sidney A. Katz.

Format:

Book

Contributor:

Salem, Harry, 1929-

Katz, Sidney A., 1935-

Language:

English

Subjects (All):

Toxicity testing--In vitro.

Toxicity testing.

Alternative toxicity testing.

Animal Testing Alternatives.

Drug Evaluation.

Medical Subjects:

Animal Testing Alternatives.

Drug Evaluation.

Physical Description:

xx, 450 pages : illustrations ; 25 cm

Place of Publication:

Washington, D.C. : Taylor & Francis, ©1998.

Summary:

This new book presents state-of-the-art concept and approaches to the theory and practice of alternatives to animal testing in laboratory research. It reports on the latest progress in developing and evaluating alternatives to experimental animals. The editors and their contributors focus on the three Rs of alternatives to animal testing: Reduction in the number of animals used; Refinement in minimizing discomfort, maximizing information obtained from each animal, and utilizing animals lower on the phylogenetic tree; and Replacement of animals with in vitro cultures, chemical systems, and computer models. This timely book extends the traditional three Rs to include a fourth "R": Responsibility to the commitment of the pursuit of alternatives for reasons of humaneness, time, and economics.

Contents:

Pseudo-epidermis: an in vitro surrogate for the study of cutaneous sulfur mustard toxicity / I.A. Bernstein ... [et al.]

Refinement of an endpoint for measuring skin decontaminant efficacy / J.A. Blank ... [et al.]

An in vitro model for skin reconstruction / R. Fleischmajer ... [et al.]

Critique of cell culture methods in skin permeability assessment / Gordon L. Flynn

The local lymph node assay and other approaches to the evaluation of skin sensitizing potential / Ian Kimber

The alternative to animals for assessing topical irritants is humans / Albert M. Kligman

Hexose monophosphate shunt activity in human epidermal keratinocytes exposed to sulfur mustard / Margaret E. Martens

What is irritant dermatitis?: a biological approach / Sunita Patil, K. Lamintausta, and Howard I. Maibach

Skin[superscript 2]: an in vitro tissue model for assessment of cutaneous safety and efficacy needs / Lawrence A. Rheins, Tracy A. Donnelly, and Susan M. Edwards

Biochemical and flow cytometric studies of the mechanism of action of sulfur mustard using human cells in culture / William J. Smith ... [et al.]

A multiphase screen for the evaluation of topical skin protectants against chemical warfare agents / T.H. Snider ... [et al.]

Induction of low-molecular-weight heat-shock proteins in Drosophila and human embryonic lineage cells after teratogen exposure / Nicole Bournias-Vardiabasis ... [et al.]

Using invariants of swimming motion in biotoxicity testing via computerized microscopy / David K. Cohoon, R. James Swanson, and Ronald J. Young

Computation of developmental toxicity potential by QSTR models in the TOPKAT program / Kurt Enslein ... [et al.]

Activity profiles of developmental toxicity / Robert J. Kavlock

Screening of populations of women at risk for reproductive failure using cultured rodent embryos / Norman W. Klein

Continued evaluation and application of a bioluminescent bacterial genotoxicity test / W.-D. Wang, T.S.C. Sun, and H.M. Stahr

Cytokine gene expression and allergic contact dermatitis / Craig A. Elmets

Strategies for developing alternative methods to assess contact allergens / Anthony A. Gaspari

Astrocytes as target site for neurotoxicity / Michael Aschner

Altered angiotensin-induced drinking as a noninvasive behavioral biomarker of neonatal glutamic acid neurotoxicity in the rat / Florence A. Caputo and Andrew C. Scallet

Cell cultures for screening of antiesterase compounds / Marion Ehrich

Mechanistic neurotoxicity studies using PC12 cells / Gary E. Isom, A.G. Kanthasamy, and J.L. Borowitz

MDCK: an epithelial cell line model of the blood-brain barrier and its response to cholinesterase inhibitors / Bellina Veronesi and Marion Ehrich.

(Continued) The blood-perfused pig ear: a potential in vitro alternative for dermal permeation and toxicity studies / Piet Bruijnzeel ... [et al.]

Bovine corneal opacity and permeability test validation as an alternative to the Draize eye irritation assay / D. Cerven and O. Moreno

Metabolism of humans and animals compared by organ cultures / Byong Han (Paul) Chin

Sulfur mustard-increased proteolysis in cultured human cells / Fred M. Cowan, Clarence A. Broomfield, and William J. Smith

Evaluation of two in vitro human skin equivalents (Epiderm[superscript TM] and Skin[superscript 2 TM] Model ZK1300) for assessing the skin irritation potential of personal care products and chemicals / Joanna M. Doyle, William E. Dressler, and S.R. Rachui

Strategies of applications of in vitro methods to the development of pharmaceuticals and devices / Shayne C. Gad

A modular approach to validation: a work in progress / Alan M. Goldberg, Leonardo D. Epstein, and Joanne Zurlo

Evaluation of the CORROSITEX method to determine the corrosivity potential of surfactants, surfactant-based formulations, chemicals, and mixtures / Virginia C. Gordon, Soheila Mirhashemi, and Rosalind Wei

Comparison study of in vitro and in vivo results on textile fabric extracts for assessing dermal irritancy potential to industrial workers / Virginia C. Gordon ... [et al.]

Validation issues for alternatives testing / Stanley B. Gross

Intra- and interlaboratory reproducibility of EpiDerm, an in vitro model for dermal irritancy testing / M. Klausner ... [et al.]

Primary human hepatocytes as an in vitro toxicology system / Albert P. Li ... [et al.]

Review of the up-and-down method for acute toxicity determination / Robert L. Lipnick ... [et al.]

Skin partitions as a screen for dermal permeability / D.R. Mattie and James N. McDougal

Reduction of animal utilization in dermal toxicologic studies / Ronald G. Menton ... [et al.]

Computerized in vitro test for chemical toxicity based on Tetrahymena swimming patterns / David A. Noever ... [et al.]

Renal alterations following sublethal mercury toxicity: a fish model for aquatic environment contamination / R. Reimschuessel and C.M. Gonzalez

A nonlethal, anesthetized canine model used to reduce the number of animals required to evaluate the effectiveness of pretreatment compounds challenged with toxic concentrations of cyanide / J.A. Vick ... [et al.]

Confocal microscopy and calcium images of keratinocytes exposed to sulfur mustard / Robert J. Werrlein ... [et al.]

Inherited and acquired enzyme defects in multiple chemical sensitivity / Patricia P. Wilcox

An in vitro method for detecting toxicants by changes in the pattern of polarized light scattered from bacteria / B.V. Bronk ... [et al.]

Attaining a rational refinement and reduction in the use of live animals: studies on cyanide toxicity / Edward U. Maduh, Steven I. Baskin, and Harry Salem

Integration of alternative tests into a toxicology research program / Sidney Green and Saura C. Sahu.

Notes:

Expanded ed. of: Animal test alternatives. New York : M. Dekker, c1995.

Includes bibliographical references and index.

ISBN:

1560326239

9781560326236

OCLC:

36283955

Online:

Publisher description