Metabolomics : a path towards personalized medicine / edited by Mahbuba Rahman.

Format:

Book

Contributor:

Rahman, Mahbuba, editor.

Language:

English

Subjects (All):

Metabolism.

Metabolites.

Precision medicine.

Genre:

Electronic books.

Physical Description:

1 online resource

Place of Publication:

Amsterdam : Academic Press, 2023.

Contents:

Intro

Metabolomics: A Path Towards Personalized Medicine

Copyright

Contents

Contributors

About the editor

Preface

Chapter 1 Personalized medicine

1.1 Introduction and historical perspective

1.2 Conventional medicine vs. personalized medicine

1.3 Enabling technologies

1.3.1 Genomics

1.3.2 Transcriptomics

1.3.3 Proteomics

1.3.4 Metabolomics

1.3.5 Microbiome

1.3.6 Epigenomics

1.3.7 Bioinformatics

1.3.8 Clinical phenotyping and digital health technologies

1.4 The potential of personalized medicine

1.4.1 Prediction of disease risk

1.4.2 Precision diagnosis

1.4.3 Prediction of drug response

1.4.4 Prediction of disease prognosis

1.5 Implementing personalized medicine in clinical practice: Policies, regulation, support, and challenges

1.6 The cost-effectiveness of personalized medicine

1.7 The future of personalized medicine

References

Chapter 2 Metabolomics for personalized medicine

2.1 Introduction

2.2 Technological platforms to measure metabolites

2.2.1 Biochemical assays

2.2.1.1 Ligand-binding assays

2.2.1.2 Fluorescence technologies

2.2.1.3 Microplate assay for spectrometric measurement of mitochondrial enzyme activity

2.2.2 Cell-based assays

2.2.2.1 Fluorometric assays

2.2.2.2 Fluorescence microscopy and genetically encoded biosensors

2.2.2.3 Flow cytometry-based methods

2.2.2.4 Phenotype microarrays:

2.2.3 Biophysical methods

2.2.3.1 Nuclear magnetic resonance (NMR) spectroscopy

2.2.3.2 Mass spectrometry (MS)

2.2.3.3 Data preprocessing

2.2.3.4 Statistical analysis

2.2.3.5 Metabolic flux analysis

2.3 Metabolomic workflow for personalized medicine

2.3.1 Preanalytical workflow

2.3.1.1 Experiential design

2.3.1.2 Sample type/matrix

2.3.1.3 Sample handling, storage, and extraction method

2.3.1.4 Concentrate

2.3.1.5 Vessels/containers

2.3.2 Analytical methods

2.3.3 Biomarker discovery

2.3.4 Validation

2.4 Current challenges of metabolomics for personalized medicine

2.4.1 Technological platforms

2.4.2 Data preprocessing

2.4.3 Sample size

2.4.4 Demographic impacts for personalized medicine and challenges

2.4.5 Epidemiological challenges

2.5 Conclusion

References

Chapter 3 Metabolomics in clinical diagnosis, prognosis, and treatment of infectious diseases

3.1 Introduction

3.2 Metabolomics analytical approaches in infectious diseases

3.3 Metabolomics in diagnosis, prognosis, and management

3.3.1 Metabolomics of viral diseases

3.3.1.1 Metabolomics in AIDS

3.3.1.2 Metabolomics in HBV Infection

3.3.1.3 Metabolomics in HCV infection

3.3.1.4 Metabolomics in arboviral infections

3.3.1.5 Metabolomics in COVID-19

3.3.2 Metabolomics of bacterial diseases

3.3.2.1 Metabolomics in urinary tract infection

Notes:

Includes index.

Print version record.

Other Format:

Print version: Metabolomics

ISBN:

9780323913799

0323913792

OCLC:

1363835113

Access Restriction:

Restricted for use by site license.