Biomimetic Protein Based Elastomers : Emerging Materials for the Future / edited by Namita Roy Choudhury, Julie C. Liu, and Naba K. Dutta.

Format:

Book

Contributor:

Choudhury, Namita Roy, editor.

Liu, Julie C., editor.

Dutta, Naba K., editor.

Series:

ISSO (Series)

Issn Series

Language:

English

Subjects (All):

Biopolymers.

Physical Description:

1 online resource (398 pages)

Edition:

First edition.

Place of Publication:

London, England : The Royal Society of Chemistry, [2022]

Summary:

Edited and contributed by pioneering researchers in the field, the book provides a timely overview of the materials, along with the synthesis techniques, the unique characteristics of elastomeric proteins, and biomedical and industrial applications.

Contents:

Intro

Title

Copyright

Contents

Chapter 1 Biomimetic Protein-based Elastomers: Emerging Materials for the Future

1.1 Introduction

Chapter 2 Native Resilin: Properties, Occurrence and Biological Functions of a Remarkable Bio-elastomer

2.1 Native Resilin - The Pliant Protein

2.2 Occurrence and Functions of Resilin in Different Arthropod Exoskeleton Systems

2.2.1 Arthrodial Membranes

2.2.2 Legged Locomotion

2.2.3 Flight Systems: Folds, Tendons and Microjoints

2.2.4 Attachment Systems

2.2.5 Mouthparts

2.2.6 Reproductive Organs, Mechanoreceptors and Compound Eyes

2.3 Conclusion

Acknowledgements

References

Chapter 3 Design and Production of Chimeric Resilin-like Polypeptides (RLPs)

3.1 Introduction

3.2 Why Chimeric RLPs?

3.3 Different Design Schemes of Chimeric RLPs

3.3.1 Chimeric RLPs Containing Bioactive Peptide Sequences

3.3.2 Chimeric RLPs Comprising Peptide Sequences for Tuning Mechanical Properties

3.3.3 Chimeric RLPs Comprising Structural Protein Sequences

3.4 Production of Chimeric RLPs

3.5 Mechanical Properties of Chimeric RLPs

3.6 Potential Applications of Chimeric RLPs

3.7 Future Perspectives

Chapter 4 Intrinsically Disordered and Resilin-based Protein Polymers for High-performance Biomaterials Applications

4.1 Intrinsically Disordered Proteins (IDPs)

4.2 Structural Proteins: Naturally Occurring IDPs

4.3 Recombinantly Derived Intrinsically Disordered Protein Polymers (IDPPs)

4.3.1 Mechanical Properties and Advantages

4.3.2 Thermally Responsive Properties and Advantages

4.4 IDPPs in High-performance Materials

4.5 IDPPs in Structured Biomaterials

4.5.1 IDPPs as Building Blocks for Self-assembled Structures

4.5.2 IDPPs in Microstructured Hydrogels

4.6 IDPPs for Tissue Engineering Applications.

4.6.1 Vocal Fold Tissue Engineering

4.6.2 Cardiovascular Tissue Engineering

4.6.3 Cartilage Tissue Engineering

4.7 Conclusions and Perspectives

Chapter 5 Resilin-mimetic Polypeptides and Elastomeric Modular Protein Polymers: Amino Acid Sequence, Conformational Ensemble, and Stimuli Responsiveness

5.1 Introduction

5.2 Synthesis and Purification

5.3 Amino Acid Sequence, Composition, and Molecular Structure Prediction

5.4 Structural Investigation by Experimental Methods

5.4.1 Circular Dichroism (CD) Spectroscopy

5.4.2 Fourier-transform Infrared Spectroscopy

5.4.3 NMR Spectroscopy

5.4.4 Small-angle Scattering

5.5 Multistimuli Responsiveness

5.5.1 Temperature and Ion Responsiveness

5.5.2 pH and Light Responsiveness

5.5.3 Responsiveness to Different Substrate Surfaces

5.5.4 Mechanical Responsiveness

5.6 Modular Self-assembly

5.7 Conclusions

5.8 Outlook

Abbreviations

Chapter 6 Advanced Biomedical Applications of Self-assembled Elastin-like Recombinamer Structures

6.1 Introduction

6.2 Elastin-like Recombinamers (ELRs): Definition, Description, and Characteristics

6.3 Self-assembly in ELRs

6.3.1 Concept of Self-assembly

6.3.2 Morphologies of Self-assembled ELR Structures

6.4 ELRs as Intrinsically Disordered Proteins and Their Impact on Self-assembled Structures: Concept and Characteristics

6.4.1 Concept of Intrinsic Protein Disorder

6.4.2 ELRs as Intrinsically Disordered Proteins

6.4.3 Example

6.5 Biomedical Applications of Self-assembled ELR Structures

6.5.1 Drug Delivery

6.5.2 Tissue Engineering

6.5.3 Biomedical Devices

6.6 Conclusions

Chapter 7 Smart Nanofibrous Materials for Tissue Engineering

7.1 Introduction

7.2 Self-assembling Peptides and Protein Nanofibers.

7.2.1 α-Helical Coiled-coil Nanofibers

7.2.2 Elastin and Elastin-like Polypeptide Nanofibers

7.2.3 Silk and Silk-like Protein Nanofibers

7.2.4 Collagen and Collagen-mimetic Peptides

7.3 Polymer-based Smart Nanofibers

7.3.1 pH-responsive Nanofibers

7.3.2 Thermoresponsive Nanofibers

7.3.3 Electroresponsive Nanofibers

7.3.4 Piezoelectric Nanofibers

7.3.5 Magnetoresponsive Nanofibers

7.4 Conclusion

Chapter 8 Biomimetic Adhesives for Clinical Applications

8.1 Clinical Applications of Surgical Adhesives

8.1.1 Clinical Need for Surgical Adhesives

8.1.2 Key Design Requirements - Performance and Safety

8.1.3 FDA Regulation of Surgical Adhesives

8.1.4 FDA Guidance for Testing of Surgical Adhesives

8.2 Natural Biomimetic Adhesives

8.2.1 Biomimetic Adhesion

8.2.2 Pressure-sensitive Adhesion

8.2.3 Mechanical Adhesion

8.2.4 Dry Adhesion

8.2.5 Intermolecular Interactions

8.3 Mussel-inspired Adhesion

8.3.1 Mussel Adhesive Chemistry

8.3.2 Mussel Foot Proteins (mfps)

8.3.3 Commercial Production of mfps

8.4 Nature-inspired Surgical Adhesives for Soft Tissues

8.4.1 Materials for Surgical Adhesives

8.4.2 Synthetic Polymer-based Adhesive Biomaterials

8.4.3 Protein-based Adhesive Biomaterials

8.4.4 Conclusions and Future Directions

Chapter 9 Silk-elastin-like Protein-based Polymers for Controlled Delivery Applications

9.1 Introduction

9.1.1 Structure-Function Relationships

9.1.2 Physical Characterization of Hydrogel-forming Silk-elastin-like Protein Polymers (SELPs)

9.1.3 Recombinant Synthesis, Expression, and Purification

9.2 Controlled Release From SELPs

9.2.1 Adenoviral Delivery

9.2.2 Controlled Release of Synthetic Glycosaminoglycans.

9.3 SELPs as Embolics, Chemoembolics, and Embolization Visualization Systems

9.3.1 Chemoembolic SELPs

9.3.2 SELP Embolics for Fluorescence Image-guided Surgery

9.4 Ophthalmic Application

9.5 Micellar-like SELP Particles

9.5.1 Mucoadhesive SELP Nanoparticles

9.6 Three-dimensional Nanoparticle Networks

9.7 Cellular Delivery

9.8 Summary and Future Directions

Chapter 10 Processing and Properties of Regenerated Bombyx mori Silk and Recombinant Spider Silk Fibers

10.1 Introduction

10.2 Production/Preparation and Preconditioning of Silk Materials for Technical Processing

10.2.1 Regeneration and Preconditioning of B. mori Fibroin

10.2.2 Recombinant Production of Spider Silk Proteins

10.2.3 Preparation and Conditioning of Silk Solutions for Technical Processing

10.3 Artificial Silk Fibers and Nonwovens

10.3.1 Wet Spinning

10.3.2 Dry Spinning

10.3.3 Microfluidic Spinning

10.3.4 Electrospinning

10.4 Conclusion and Future Prospects

Chapter 11 Protein, Biomimetic Protein, and Designer Peptide-directed Synthesis of Metal Nanoparticles, Metal Nanoclusters and Nanobioconjugates, and Their Potential Applications

11.1 Introduction

11.2 Nanoparticles (NPs) and Nanoclusters (NCs): Effect of the Size and the Shape

11.3 Statistics and Network Visualization

11.4 Nanoparticles and Nanoclusters-A Historical Perspective and the Fundamental Principles

11.4.1 Metal Nanoparticles (m-NPs) and Localized Surface Plasmon Resonance

11.4.2 Metal Nanoclusters (m-NCs) and Photoluminescence

11.5 Synthesis of m-NPs and m-NCs

11.5.1 Biomineralization and Biomimetic Synthesis of NPs and NCs

11.5.2 Artificial Synthesis of m-NPs and m-NCs

11.6 Protein, Recombinant Protein, and Polypeptide-directed Synthesis of m-NPs and m-NCs.

11.6.1 Biogenic Synthesis

11.6.2 Role of Amino Acids in the Process of the Formation and Structuring of Nanocrystals

11.6.3 Native Protein-directed Synthesis of m-NPs

11.6.4 Recombinant Protein and Polypeptide-directed Synthesis of m-NPs

11.6.5 Peptoid-directed Synthesis on m-NPs

11.6.6 Molecular Simulation and Structural Insights at Atomic-scale Resolution

11.7 Engineering Ultrasmall m-NCs

11.8 Applications of m-NPs and m-NCs

11.8.1 Antibacterial Activity against Multidrug-resistant Bacteria

11.8.2 Application of NPs and NCs as Sensors

11.8.3 Application of NPs and NCs in Catalysis

11.9 Conclusions and Perspectives

Dedication

Subject Index.

Notes:

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Includes bibliographical references.

ISBN:

9781788012720

1788012720

9781839161025

1839161027