Supramolecular Chemistry in Biomedical Imaging / edited by Stephen Faulkner, Thorfinnur Gunnlaugsson, and Gearoid O Maille.

Format:

Book

Contributor:

Faulkner, Stephen, editor.

Gunnlaugsson, Thorfinnur, editor.

Ó Máille, Gearóid, editor.

Series:

ISSO (Series)

Issn Series

Language:

English

Subjects (All):

Biomedical materials--Imaging.

Biomedical materials.

Imaging systems in medicine.

Supramolecular chemistry.

Physical Description:

1 online resource (382 pages)

Edition:

First edition.

Place of Publication:

Cambridge, England : The Royal Society of Chemistry, [2022]

Summary:

There have been great advances in biomedical imaging techniques in recent years and they are becoming prominent in supramolecular chemistry. This book will clarify the current understanding of these techniques.

Contents:

Intro

Halftitle

Series Editors

Title

Copyright

Preface

Contents

Chapter 1 Targeting Supramolecular Imaging Agents for a Wide Range of Applications

1.1 Introduction

1.2 Luminescent Agents

1.2.1 Targeting (Organic) Fluorescent Imaging Agents

1.2.2 Luminescent Lanthanide Imaging Agents

1.2.3 Paramagnetic Imaging Agents

1.2.4 Self-assembling Aggregates of Amphiphilic Ln(iii) Complexes

1.3 Summary

Acknowledgements

References

Chapter 2 Optical Spectroscopies: Detection of Biological Species, Conformations and Interactions

2.1 Introduction

2.2 Linear Electronic Spectroscopies

2.2.1 Time-resolved Spectroscopies

2.2.2 Polarized Light

2.3 Non-linear Spectroscopies

2.3.1 Electronic Spectroscopies

2.3.2 Vibrational Spectroscopies

2.4 Conclusion

Chapter 3 Super-resolution Microscopy

3.1 Introduction

3.1.1 Optical Microscopy

3.1.2 The Resolution Barrier

3.2 Deconvolution Microscopy

3.3 Non-linear Microscopy

3.3.1 Multi-photon Microscopy

3.3.2 Second and Third Harmonic Generation Microscopy

3.4 Super Resolution Microscopy: Breaking the Diffraction Limit

3.4.1 STED Microscopy

3.4.2 Single Molecule Localisation Techniques

3.4.3 Structured Illumination Microscopy

3.4.4 Pointillistic Structured Illumination Microscopy

3.4.5 Applications of Adaptive Optics and PSF Engineering

3.4.6 Future Challenges

Chapter 4 The Role of Fundamental Coordination Chemistry in the Development of Radioimaging Agents

4.1 Introduction: Significance and Scope

4.2 Categories of Metallo-radiopharmaceuticals, Metals and Ligands

4.2.1 Relevant Coordination Chemistry of Technetium

4.2.2 Relevant Coordination Chemistry of Gallium and Indium

4.2.3 Relevant Coordination Chemistry of Copper.

4.2.4 Relevant Coordination Chemistry of Yttrium

4.2.5 Relevant Coordination Chemistry of Zirconium

4.3 Selected Examples of the Chemistry of Metallo-radiopharmaceuticals

4.3.1 Single Amino Acid Chelates for the {99mTc(CO)3}+ Core168

4.3.2 Utilization of Vitamin B12 in Imaging Agent Development

4.3.3 Novel PET Agents Based on 89Zr

4.3.4 68Gallium-labelled Radiopharmaceuticals for Somatostatin Receptor Imaging

Chapter 5 Supramolecular Aspects of Magnetic Resonance Imaging

5.1 Introduction

5.2 Relaxivity

5.3 Commercial Gd Contrast Agents

5.4 Safety

5.5 Responsive Contrast

5.6 Conclusions

Chapter 6 Lanthanide Containing Systems for Molecular Magnetic Resonance Imaging and Therapy

6.1 Introduction

6.2 Responsive Probes for Endogenous Triggers

6.2.1 pH Detection

6.2.2 Cation Detection: the Example of Zinc

6.2.3 Enzymatic Detection

6.3 Targeted Probes

6.3.1 Limitations of Targeted MRI: Sensitivity and Target Abundance

6.3.2 Design of Specifically Targeted Contrast Agents

6.3.3 Contrast Agents that Target Albumin

6.4 Theranostic Probes

6.4.1 Chemotherapy

6.4.2 Photodynamic Therapy

6.4.3 Radiation Therapy

6.5 Conclusion

Chapter 7 Molecular Imaging in Diagnosis and Treatment of Brain Tumours

7.1 Introduction

7.1.1 The Brain and Neuro-oncology

7.1.2 Risk Factors for Brain Tumours

7.1.3 Current Treatments for Brain Tumours

7.2 Delivery of Therapies and Imaging Agents to the Central Nervous System

7.2.1 Strategies for Enhancing Delivery Across the BBB (e.g. Ultrasound, Peptides)

7.3 Current Methods for Diagnosis and Monitoring Treatment of Brain Tumours

7.3.1 Biopsy

7.3.2 Imaging for Diagnosis of Brain Tumours

7.4 Summary and Outlook

Chapter 8 Carbon Nanomaterials for Imaging.

8.1 Introduction

8.2 Carbon Nanomaterials

8.3 Carbon Nanotubes (CNTs)

8.3.1 Biocompatibility of Carbon Nanotubes

8.3.2 In Vitro and In Vivo Imaging of Carbon Nanotubes

8.4 Graphene Quantum Dots (GQDs) and Carbon Dots (C-dots)

8.4.1 Graphene Quantum Dots (GQDs)

8.4.2 Carbon Dots (C-dots)

8.4.3 Biocompatibility of C-dots and GQDs

8.4.4 In vitro and In Vivo Imaging of C-dots and GQDs

8.4.5 Conclusions

8.5 Graphene Oxide (GO)

8.5.1 In vitro and In Vivo Imaging of GO

8.5.2 Conclusions

8.6 Fullerene

8.6.1 Biocompatibility

8.6.2 Imaging

8.7 Carbon Nano-onions (CNOs)

8.7.1 Biocompatibility of Carbon Nano-onions

8.7.2 In vitro and In Vivo Imaging of Carbon Nano-onions

8.8 Nanodiamonds

8.8.1 Biocompatibility

8.8.2 Imaging

8.9 Conclusions and Outlook

Chapter 9 Quantum Dots in Biological Imaging

9.1 Introduction

9.2 Modification of QDs used for Bioimaging

9.2.1 Solubilization of QDs

9.2.2 Bioconjugation and Targeting of QDs

9.3 Influence of Microenvironment and Stability

9.4 Cytotoxicity

9.5 Application of CQDs in Bioimaging

9.5.1 Application of CQDs in Cell Analysis and Imaging

9.5.2 Application of CQDs in In Vivo Imaging

9.6 Conclusions and Future Outlook

Chapter 10 Future Directions in Biomedical Imaging Using Supramolecular Chemistry

Subject Index.

Notes:

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Includes bibliographical references.

ISBN:

1-78262-402-3

1-83916-137-X