Polysaccharide-Based Biomaterials : Delivery of Therapeutics and Biomedical Applications / Sougata Jana, Subrata Jana, and Abraham J. Domb.

Format:

Book

Author/Creator:

Jana, Sougata, author.

Jana, Subrata, author.

Domb, A. J. (Abraham J.), author.

Series:

ISSN

Issn Series

Language:

English

Subjects (All):

Polysaccharides--Biotechnology.

Polysaccharides.

Biomedical materials.

Physical Description:

1 online resource (610 pages)

Edition:

First edition.

Place of Publication:

London, England : Royal Society of Chemistry, [2023]

Summary:

With contributions from around the world, the editors have pulled together a tightly curated set of chapters which showcase how polysaccharide-based materials are employed in a range of biomedical systems.

Contents:

Intro

Title

Copyright

Contents

Chapter 1 Polysaccharide-based Biomaterials: Overview

1.1 Introduction

1.2 Cellulose

1.3 Chitosan

1.4 Modifications

1.5 Hyaluronic Acid

1.6 Dextran

1.7 Alginates

1.8 Pullulan

1.9 Chondroitin Sulfate

1.10 Conclusion

References

Chapter 2 Recent Approaches in Alginate-based Carriers for Delivery of Therapeutics and Biomedicine

2.1 Introduction

2.2 Alginate

2.2.1 Alginate: Chemical Structure and Characterization

2.2.2 Extraction of Alginate from Brown Seaweed Algae

2.3 Alginate-based Colloidal Systems

2.3.1 Alginate in Different Colloidal Systems

2.4 Alginate-based Carrier Applications in Delivery Systems and Biomedicine

2.4.1 Therapeutic Applications

2.4.2 Drug-controlled Release Systems

2.4.3 Biomedical Applications

2.5 Conclusions

Acknowledgements

Chapter 3 Alginate-based Carriers for Transdermal Drug Delivery

3.1 Introduction

3.2 Alginate: Sources, Physicochemical, and Biological Properties

3.2.1 Sources of Alginates

3.2.2 Physicochemical Properties

3.2.3 Biological Properties of Alginates

3.3 Preparations of Different Alginate-based Transdermal Systems

3.3.1 Alginate Films

3.3.2 Alginate-based Microneedles for Transdermal Drug Delivery

3.3.3 Alginate-based Electroresponsive Transdermal Drug Delivery System

3.4 Drug Delivery Application of Alginate Based Transdermal Carriers

3.4.1 Delivery of Antidiabetic Agents

3.4.2 Delivery of Anticancer Agents

3.4.3 Delivery of Anti-inflammatory Agents

3.4.4 Delivery of Antibiotics

3.4.5 Delivery of Antihypertensive Agents

3.4.6 Delivery of Antifungal Agents

3.4.7 Delivery of Antimicrobial Agents

3.4.8 Delivery of Antioxidants

3.4.9 Delivery of Anti-alopecia Agents

3.4.10 Miscellaneous

3.5 Conclusion

References.

Chapter 4 Chitosan-based Nanocarriers for Drug Delivery: Advances and Challenges

4.1 Introduction

4.2 Chitosan-based Drug Delivery Nanocarriers

4.2.1 Nanoparticles

4.2.2 Nanogels

4.2.3 Nanomicelles

4.2.4 Physicochemical Characterization of Nanospheres, Nanocapsules, and Nanogels

4.2.5 Nanofibers

4.3 Summary and Future Perspectives

Abbreviations

Chapter 5 Hyaluronic Acid in Drug Delivery

5.1 Introduction

5.1.1 Properties

5.1.2 Synthesis and Degradation

5.2 Application of Hyaluronic Acid in Drug Delivery Systems

5.2.1 HA in Parenteral Delivery

5.2.2 HA in Pulmonary Delivery

5.2.3 HA in Ocular Delivery

5.2.4 HA in Nasal Delivery

5.2.5 HA in Oral Delivery

5.2.6 HA in Vaginal Delivery

5.2.7 HA in Topical Delivery

5.2.8 HA in Tissue and Regenerative Medicine

5.2.9 HA in Anti-cancer Drug Delivery Systems

5.2.10 HA in Protein and Peptide Delivery

5.2.11 HA in Targeted Drug Delivery Systems

5.2.12 HA in Self-assembling Systems

5.3 Application of Hyaluronic Acid in Gene Delivery Systems

5.4 Application of Hyaluronic Acid in Imaging

5.4.1 Fluorescence Imaging

5.4.2 Magnetic Resonance Imaging

5.4.3 Theranostic Applications

5.5 Challenges and Opportunities

5.6 Conclusion

Chapter 6 Dextran in the Delivery of Therapeutics: Chronicle of the Journey from Preclinical to Clinical Trials

6.1 Introduction

6.2 Dextran: An Extraordinary 'Slime' from the Bounty of Nature

6.2.1 Chemistry of Dextran

6.2.2 Physicochemical Properties of Dextran That Contribute to Its Superior Carrier Status

6.2.3 Methods of Synthesis

6.3 Preclinical Success Stories

6.4 Clinical Trials of Dextran as a Carrier

6.5 Future Perspectives

6.6 Conclusion

Chapter 7 Guar Gum-based Biomaterials in the Delivery of Therapeutics

7.1 Introduction

7.1.1 Gums/Polysaccharides as a Choice for Therapeutics

7.2 Why Guar Gum?

7.2.1 Guar Gum Processing

7.3 Synthesis of Guar Gum-based Therapeutics

7.3.1 Antihypertensive Drugs

7.3.2 Anticancer Drugs

7.3.3 Anti-infective Drugs

7.3.4 Anti-inflammatory

7.4 Different Ways of Giving Drugs Using a Polymer Blend

7.4.1 Particulate Level Blends

7.4.2 Colloidal Level Blends

7.4.3 The Molecular-level Blends

7.4.4 Excipients

7.4.5 Film Coatings and Oral Films

7.4.6 Tablets

7.4.7 Capsules

7.5 Applications

7.5.1 Guar Gum-based Microparticles for Drug Delivery

7.5.2 Guar Gum-based Nanoparticles for Drug Delivery

7.5.3 Guar Gum-based Nanoparticles as Self-healing, Injectable, and Antibacterial Biomaterials

7.5.4 Self-healing Properties

7.5.5 Injectable and Antibacterial Properties

7.5.6 Guar Gum-based Grafted Systems for Drug Delivery

7.5.7 Guar Gum-based Hydrogel Systems for Drug Delivery

7.5.8 Guar Gum-based Buccal Film for Drug Delivery

7.5.9 Guar Gum-based Tablets for Drug Delivery

7.6 Guar Gum-based Microsphere for Delivery of Anticancer Drugs

7.7 Toxicity Status of Guar Gum-based Therapeutics

7.8 Alternatives to Guar Gum

7.9 Conclusion

Chapter 8 Gellan Gum-based Drug Delivery Carriers

8.1 Introduction

8.2 Sources and Production of Gellan Gum

8.2.1 Factors Affecting Gellan Gum Production

8.2.2 Isolation of Gellan Gum from the Culture Broth

8.2.3 Purification of Gellan Gum

8.3 Chemistry of Gellan Gum

8.4 Physicochemical Properties of Gellan Gum

8.5 Rationale of Gellan Gum as a Drug Carrier

8.6 Chemical Modifications of Gellan Gum for Benefits of Drug Delivery

8.6.1 Carboxymethylation

8.6.2 Graft-copolymerization

8.6.3 Oxidation.

8.6.4 Alkylation

8.6.5 Gellan-Thioglycolic Acid Conjugate

8.7 Gellan Gum-based Drug Delivery Carriers

8.7.1 Gellan Gum-based Beads

8.7.2 Gellan Microparticles

8.7.3 Gellan Pellets

8.7.4 Gellan-based In Situ Gel

8.7.5 Tablets

8.7.6 Hydrogels

8.7.7 Micelles

8.7.8 Gellan Nanoparticles

8.7.9 Gellan as an Emulsion Stabilizer

8.7.10 Gellan-based Nanofiber

8.8 Conclusion

Chapter 9 Locust Bean Gum - A Potential Drug Delivery Carrier

9.1 Introduction

9.2 Locust Bean Gum

9.2.1 Manufacture

9.2.2 Processing

9.2.3 Composition

9.2.4 Chemical Structure

9.3 Properties of LBG

9.3.1 Solubility

9.3.2 Viscosity

9.3.3 Molecular Weight

9.3.4 Hydration Rate

9.3.5 Water Adsorption Isotherm

9.3.6 Synergistic Gel Formation

9.4 Biological Activity of LBG

9.5 Biocompatible and Biodegradable Nature of LBG

9.6 Drug Delivery Applications

9.6.1 Oral Drug Delivery

9.6.2 Buccal Drug Delivery

9.6.3 Colonic Drug Delivery

9.6.4 Topical Drug Delivery

9.6.5 Ocular Drug Delivery

9.6.6 Inhalable LBG Microparticles

9.6.7 Solubility Improvement of Poorly Water-soluble Drugs

9.6.8 Tissue Engineering Application of LBG

9.7 Conclusions

Chapter 10 Pectin-based Vehicles for Delivery of Therapeutics

10.1 Introduction

10.2 Overview of Pectin as a Biomaterial

10.3 Variety of Pectin-based Delivery Vehicles

10.4 Pectin as a Suitable Mucoadhesive Vehicle

10.5 Range of Therapeutics Delivered via Pectin Vehicles

10.5.1 Pectin Vehicles for Small Molecular Drug Delivery

10.5.2 Pectin Vehicles for Gene Delivery

10.6 Therapeutic Applications of Pectin-based Drug Delivery Vehicles

10.6.1 Oral Delivery

10.6.2 Systemic Delivery

10.6.3 Intranasal Delivery

10.6.4 Topical Delivery

10.6.5 Ocular Delivery.

10.6.6 Vaginal Delivery

10.7 Clinical Progress

10.8 Summary

10.9 Challenges and Future Perspectives

List of Abbreviations

Conflicts of interest

Chapter 11 Pullulan in the Delivery of Therapeutics

11.1 Introduction and Background

11.2 Pullulan as a Drug Carrier

11.3 Pullulan Derivatives as Drug Carriers

11.4 Pullulan-based Therapeutic Laborers with Bactericidal and Fungicidal Activities

11.5 Pullulan-based Anticancer Laborers

11.6 Pullulan-based Antioxidant Laborers with Radical Leaching Potentiality

11.7 Pullulan-based Therapeutic Laborers with Anti-inflammatory and Immunomodulatory Performance

11.8 Pullulan-based Therapeutic Laborers for Bone Illness

11.9 Conclusion

Chapter 12 Carrageenan-based Carriers for Therapeutic Delivery

12.1 Introduction

12.2 Sources of Carrageenan

12.3 Extraction of Carrageenan

12.4 Production

12.5 Chemical Structure

12.6 General Properties

12.7 Modification of Carrageenan

12.8 Carrageenan-based Carriers

12.8.1 Hydrogels

12.8.2 Tablets

12.8.3 Beads

12.8.4 Suppositories

12.8.5 Oral Suspensions

12.8.6 Pallets

12.8.7 Internasal Systems

12.8.8 Micro/nanoparticles

12.8.9 Wafers

12.9 Applications of Carrageenan in Therapeutic Delivery

12.9.1 Oral Delivery

12.9.2 Opthalmic

12.9.3 Nasal Delivery

12.9.4 Transdermal

12.10 Conclusion

Chapter 13 Xanthan Gum in Drug Carriers

13.1 Introduction

13.1.1 History of Xanthan Gum

13.1.2 Production

13.1.3 Chemical Composition and Structure

13.1.4 Physico-chemical Properties

13.2 Modifications

13.2.1 Carboxymethylation

13.2.2 Grafting

13.2.3 Phosphorylation

13.2.4 Esterification

13.2.5 Miscellaneous Modifications

13.3 Xanthan Gum for Drug Delivery Applications.

13.3.1 Nanoparticles.

Notes:

Description based on print version record.

ISBN:

9781839166235

1839166231

9781839166242

183916624X