Pathophysiology of preeclampsia and eclampsia / edited by Junie P Warrington, Ana T. Palei.

Format:

Book

Contributor:

Warrington, Junie P., editor.

Palei, Ana T., editor.

Language:

English

Subjects (All):

Preeclampsia.

Pregnancy.

Physical Description:

1 online resource (334 pages)

Place of Publication:

[Place of publication not identified] : MDPI - Multidisciplinary Digital Publishing Institute, [2023]

Summary:

Preeclampsia is a hypertensive disorder of pregnancy, diagnosed after the 20th week of gestation in women experiencing new-onset hypertension along with symptoms affecting the liver, kidneys, or brain. In some cases, women with preeclampsia develop novel seizures or unexplained coma, at which time they are diagnosed with eclampsia. The mechanisms contributing to preeclampsia and eclampsia are not fully elucidated, although the placenta seems to play a critical role. Previous studies suggest that improper placentation stimulates mitochondrial dysfunction and the exaggerated release of placental-derived molecules including inflammatory cytokines, anti-angiogenic factors, reactive oxygen species, and cell-free nucleic acids into the maternal circulation that cause systemic vascular dysfunction. These, along with maternally derived molecules, act in concert, leading to hypertension and target organ damage during pregnancies complicated by preeclampsia and eclampsia. In this reprint, we present the original research articles and review papers published as part of the Special Issue: "The Pathophysiology of Preeclampsia and Eclampsia" in Cells.

Contents:

About the Editors

Miguel A. Ortega, Oscar Fraile-Mart´ınez, Cielo Garc´ıa-Montero, Miguel A. Sa´ez, Miguel Angel ´Alvarez-Mon and Diego Torres-Carranza et al. The Pivotal Role of the Placenta in Normal and Pathological Pregnancies: A Focus on Preeclampsia, Fetal Growth Restriction, and Maternal Chronic Venous Disease

Barbara Fuenzalida, Sampada Kallol, Jonas Zaugg, Martin Mueller, Hiten D. Mistry and Jaime Gutierrez et al. Primary Human Trophoblasts Mimic the Preeclampsia Phenotype after Acute Hypoxia-Reoxygenation Insult

Nina-Naomi Kreis, Alexandra Friemel, Lukas Jennewein, Samira Catharina Hoock, Anna Elisabeth Hentrich and Thorsten Nowak et al. Functional Analysis of p21Cip1/CDKN1A and Its Family Members in Trophoblastic Cells of the Placenta and Its Roles in Preeclampsia

Yunhui Tang, Katie Groom, Larry Chamley and Qi Chen Melatonin, a Potential Therapeutic Agent for Preeclampsia, Reduces the Extrusion of Toxic Extracellular Vesicles from Preeclamptic Placentae

Therese Friis, Anna-Karin Wikstro¨m, Jesenia Acurio, Jose´ Leo´n, Henrik Zetterberg and Kaj Blennow et al. Cerebral Biomarkers and Blood-Brain Barrier Integrity in Preeclampsia

Lina Bergman, Roxanne Hastie, Henrik Zetterberg, Kaj Blennow, Sonja Schell and Eduard Langenegger et al. Evidence of Neuroinflammation and Blood-Brain Barrier Disruption in Women with Preeclampsia and Eclampsia

Maria Jones-Muhammad, Qingmei Shao, Loretta Cain-Shields, James P. Shaffery and Junie P. Warrington Acid Sensing Ion Channel 2a Is Reduced in the Reduced Uterine Perfusion Pressure Mouse Model and Increases Seizure Susceptibility in Pregnant Mice

Megan A.Opichka, Matthew W.Rappelt, David D.Gutterman, JustinL.Grobe and Jennifer J. McIntosh Vascular Dysfunction in Preeclampsia

Priscila Rezeck Nunes, Sarah Viana Mattioli and Valeria Cristina Sandrim NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions

Bhavisha A. Bakrania, Ana C. Palei, Umesh Bhattarai, Yingjie Chen, Joey P. Granger and Sajid Shahul Sustained Elevated Circulating Activin A Impairs Global Longitudinal Strain in Pregnant Rats: A Potential Mechanism for Preeclampsia-Related Cardiac Dysfunction

Talitha Abraham and Andrea M. P. Romani The Relationship between Obesity and Pre-Eclampsia: Incidental Risks and Identification of Potential Biomarkers for Pre-Eclampsia

Manuel S. Vidal, Christian Deo T. Deguit, Gracia Fe B. Yu and Melissa D. Amosco G-Protein Coupled Receptor Dysregulation May Play Roles in Severe Preeclampsia-A Weighted Gene Correlation Network Analysis of Placental Gene Expression Profile

Evangeline Deer, Jalisa Jones, Denise C. Cornelius, Kyleigh Comley, Owen Herrock and Nathan Campbell et al. Progesterone Induced Blocking Factor Reduces Hypertension and Placental Mitochondrial Dysfunction in Response to sFlt-1 during Pregnancy

Ursula Quitterer and Said AbdAlla Pathological AT1R-B2R Protein Aggregation and Preeclampsia

Thaina Omia Bueno-Pereira, Priscila Rezeck Nunes, Mariana Bertozzi Matheus, Ananda Lini Vieira da Rocha and Valeria Cristina Sandrim Nebivolol Increases Nitric Oxide Synthase via β3 Adrenergic Receptor in Endothelial Cells Following Exposure to Plasma from Preeclamptic Patients

Evangeline Deer, Lorena M. Amaral, Nathan Campbell, Sarah Fitzgerald, Owen Herrock and Tarek Ibrahim et al. Low Dose of IL-2 Normalizes Hypertension and Mitochondrial Function in the RUPP Rat Model of Placental Ischemia

Beata Csiszar, Gergely Galos,Simone Funke,Dora Kinga Kevey, Matyas Meggyes and Laszlo Szereday et al. Peripartum Investigation of Red Blood Cell Properties in Women Diagnosed with Early-Onset Preeclampsia

Lina Bergman, Karl Bergman, Eduard Langenegger, Ashley Moodley, Stephanie Griffith-Richards and Johan Wikstro¨m et al. PROVE-Pre-Eclampsia Obstetric Adverse Events: Establishment of a Biobank and Database for Pre-Eclampsia

Zaleha Abdullah Mahdy, Kok-Yong Chin, Nik Lah Nik-Ahmad-Zuky, Aida Kalok and Rahana Abdul Rahman Tocotrienol in Pre-Eclampsia Prevention: A Mechanistic Analysis in Relation to the Pathophysiological Framework

Benjamin P. Lu¨scher, Christiane Albrecht, Bruno Stieger, Daniel V. Surbek and Marc U. Baumann Glucose Transporter 9 (GLUT9) Plays an Important Role in the Placental Uric Acid Transport System.

Notes:

Description based on: online resource; title from PDF information screen (Amazon, viewed March 27, 2023).

ISBN:

3-0365-6410-1