MRNA vaccines / edited by Dong Yu and Benjamin Petsch.

Format:

Book

Contributor:

Yu, Dong, editor.

Petsch, Benjamin, editor.

Series:

Current Topics in Microbiology and Immunology, 2196-9965 ; 437

Language:

English

Subjects (All):

mRNA vaccines.

Physical Description:

1 online resource (215 pages)

Edition:

1st ed. 2022.

Place of Publication:

Cham, Switzerland : Springer, [2023]

Summary:

The formulation and the technological advancements in RNA biology, chemistry, stability, and encapsulated delivery systems that have enabled the development of fully synthetic mRNA vaccines are discussed in this volume. The applications of the mRNA technology is covered, focusing on infectious diseases but also touching on other indications, such as immunotherapies and molecular therapies. Potent and long-lasting immune responses observed in animal models, encouraging data from early human clinical studies, together with the success of two mRNA-based COVID-19 vaccines support the use of mRNA-based vaccination as an attractive alternative to conventional vaccine approaches. Consequently, the development progress of the technology, particularly on production, capabilities, and clinical development is reviewed. Topics on safety, regulatory issues, and possible challenges to the mRNA vaccination approach round off this book. Thanks to their high potency, the prospect for generic, low-cost manufacturing processes, and entirely synthetic nature, the future for mRNA vaccines is highly promising. Importantly, mRNA vaccines have the potential to minimize the time between pathogen identification and vaccine release with a huge impact on public health. As the mRNA-based vaccination technology has been progressing rapidly, the book is intended to be an end-to-end review series, covering everything from basic RNA biology and preclinical studies to the manufacturing strategy, clinical development and regulatory approval. It provides established RNA researchers and developers with updates on the latest advancements in the field and allows for a quick but comprehensive overview of this transformative technology, its application, and future potential.

Contents:

Preface

mRNA-based vaccines and mode of action

Self-Amplifying mRNA-Based Vaccine Technology and its Mode of Action

Formulation and Delivery Technologies for mRNA Vaccines

Messenger RNA-based vaccines against infectious diseases

Emerge gate for Therapeutics applications of mRNA based drug

Clinical Development of mRNA Vaccines: Challenges and Opportunities

Regulatory Considerations on the Development of mRNA Vaccines.

Notes:

Description based on print version record.

Other Format:

Print version: Yu, Dong MRNA Vaccines

ISBN:

3-031-18070-4