Handbook of Neurotoxicity / edited by Richard M. Kostrzewa.

Format:

Book

Contributor:

Kostrzewa, Richard M., editor.

Language:

English

Subjects (All):

Neurophysiology.

Neurons.

Nervous system--Diseases.

Nervous system.

Toxicology.

Neurochemistry.

Cellular Neuroscience.

Neurological Disorders.

Local Subjects:

Cellular Neuroscience.

Neurological Disorders.

Toxicology.

Neurochemistry.

Physical Description:

1 online resource (2551 pages)

Edition:

2nd ed. 2022.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2022.

Summary:

This handbook is a reference source for identifying, characterizing, instructing on use, and describing outcomes of neurotoxin treatments – to understand mechanisms associated with toxin use; to project outcomes of neurotoxin treatments; to gauge neurotoxins as predictors of events leading to neurodegenerative disorders and as aids to rational use of neurotoxins to model disease entities. Neuroprotection is approached in different manners including those 1) afforded by therapeutic agents – clinical and preclinical; or 2) by non-drug means, such as exercise. The amorphous term ‘neurotoxin’ is discussed in terms of the possible eventuality of a neuroprotectant producing an outcome of excess neuronal survival and a behavioral spectrum that might produce a dysfunction – akin to a neurotoxin’s effect. This new edition significantly expands on the information provided in the first edition, providing the latest research in neurotoxicity and highlighting the relationship between specific neurotoxins and the neurodegenerative disorders they can cause. It also includes new sections on the neurotoxicity of heavy metals, fungi, and snake venom. The Handbook of Neurotoxicity is thus an instructive and valuable guide towards understanding the role of neurotoxins/neurotoxicity in the expansive field of Neuroscience, and is an indispensable tool for laboratory investigators, neuroscientists, and clinical researchers.

Contents:

Cell Death Processes: Neurons and Glia

Neuronal Necrosis

Neuronal Apoptosis

Autophagy Pathways

Necrostatin Neuroprotection

Neuronal Necroptosis, Relation to Neurological Disorders

Multiple Cell Death Processes in Neurological Disorders

Micorglia: Neuroprotective and Neurodestructive Propertie.s, - Selective Neurotoxins

Survey of Selective Neurotoxinx

RCSN Cell System for Identifying Dopaminergic Neurotoxicity

Neurotoxicity: A complex multistage process

Dopaminergic and Noradrenergic Neurotoxins

Dopamine and L-dopa as Selective Endogenous Neurotoxins., Dopamine D2 Receptor Supersensitivity as a non-Degenerative Neurotoxin

Trace Amine-Associated Receptor 1 (TAAR1) and Doapmine Receptor Sensitivity

Dopamine Receptor Supersensitivity to Model Schizophrenia

Pathophysiology of Obsessive-Compulsive Disorder: Insights from Normal Function and Neurotoxic Effects of Drugs, Infection, and Brain Injury

Dopamine D3 receptors and schizophrenia / drug addiction

Tardive Dyskinesia: Outcome of Antipsychotic Treatment and Brain Damage?

6-Hydroxydopamine Neurotoxicity in Adult Animal

6-Hydroxydopamine Neurotoxicity in Perinatal Animals

6-Hydroxydopa in Perinatal and Adult Animals

MPTP Neurotoxicity Mechanisms

Dopaminergic and Noradrenergic Neurotoxins and Neurodegenerative Disorders

anti-NGF

Advances in Stem Cell Research for Parkinson's Disease

Autophagy Pathways and Parkinson's Disease

Regulation of DA Homeostasis and Role of VMAT2 in Parkinson's Disease

Alpha-Synuclein in Parkinson's Disease

Dopaminergic Neurons in Parkinson's Disease

Dopamine Oxidation and Parkinson's Disease

Neuromelanin and Parkinson's Disease., -Iron-Induced Dopaminergic Cell Death in vivo as a Model of Parkinson's Disease

Iron Neurotoxicity in Parkinson's Disease

6-Hydroxydopamine as Preclinical Model of Parkinson's Disease. - MPTP modeling of Parkinson's Disease

MPTP: Advances from and Evergreen Neurotoxin. - MPTP and Motor Neurons

MPTP Neurotoxicity: Actions, Mechanisms, and Animal Modeling of Parkinson's Disease

Paraquat and Parkinson's Disease

Rotenone Preclinical Modeling of Parkinson's Disease

N-Methyl-(R)-Salsolinol and Parkinson's Disease

Fusion Models and "Fusioning" in Parkinsonism: 1-Benzyl-1,2,3,4-tetrahydroisoquinoline

Amphetamines as Neurotoxins

METH Neurotoxicity

Neurotoxicity of MDMA

Cocaine influence of A2/D2 receptor heteromers

Cocaine as a Neurotoxin

NBOMe Neurotoxicity

Cathinone Neurotoxicity - several chapters

Neurotoxic Vulnerability Underlying Schizophrenia Spectrum Disorders

Molecular Mechanism and Effects of Clostridial Neurotoxins

Botulinum Neurotoxicity

~3 addl subchapters on Botulinum Neurotoxicity

Neurotoxic Effects, Mechanisms, and Outcome of 192-IgG Saporin

TRPV1 Activators ("Vanilloids") as Neurotoxins

Protective Agents in Parkinson's Disease:Caffeine and Adenosine A2A Receptor Antagonists

Physical Exercise as Intervention in Parkinsonism

Manganese Neurotoxicity and Parkinson's Disease

Neuroinflammation and Parkinson's Disease

Neurotoxicity in Psychostimulant and Opiate Addiction

Homocysteine and Cerebellar Damage

Propionic Acid, Modeling of Autism Spectrum Disorders

1-Me-TIQ, and endogenous Neuroprotectant

5-MeO-DIPT

3-MD-Glutaric acid

3-NP and Huntington's Disease

25C-NBOMe

M-30

Trace amine-associated receptor 1 and neuropsychiatric disorders

PACAP as a Neuroprotectant

Doxycycline as a Neuroprotectant

PCP Modeling Amnesia

Drug Abuse Neurotoxicity: Alcohol and Nicotine as Developmental Stressors

Neurotrophic Factors and Ethanol Neurotoxicity

Salsolinol and Addiction

Snake Venom Toxins

Salicylate Ototoxicity

Serotoninergic Neurotoxins

Nature of DSP-4-Induced Neurotoxicity

5,6- and 5,7-Dihydroxytryptamines as Serotoninergic Neurotoxins

2'NH(2)-MPTP: A Serotonin and Norepinephrine Neurotoxin

Excitotoxins and Excitotoxicity

Glutamate as a Neurotoxin

Aspartate as a Neurotoxin

Concept of Excitotoxicity via Glutamate Receptors

Glutamate Neurotoxicity, Transport and Alternative Splicing of Transporters

Excitotoxicity: A Complex Multistage Process Involving Different Mechanisms

Glutamate Excitotoxicity Relation to Energy Failure

Ionotropic Receptors in the Central Nervous System and Neurodegenerative Disorders

Excitotoxicity and Axon Degeneration

Glutamate Scavengers

Quinolinate and Related Excitotoxins: Mechanisms of Neurotoxicity and Disease Relevanc

Domoic Acid as a Neurotoxin

BOAA and Neurotoxicit

Endogenous Kynurenic Acid and Neurotoxicity

Neuroprotection by Kynurenine Metabolites

BMAA (beta-N-Methylamin

Ionotropic Glutamate Receptors in Neurodegenerative and Other Disorders

Okadaic acid modeling of Alzheimer's Disease

Excitotoxicity in Parkinson's Disease

Excitotoxicity and the Pathogenesis of Gliomas Excitotoxicity and Epielpsy; Epilepsy re Neurotoxicity Mechs

Excitotoxicity in Multiple Sclerosis

Excitotoxicity: Insights into Pathogenesis of AD

Excitotoxicity and ALS: Insights into Pathogenesis

Excitotoxicity and Amyotrophic Lateral Sclerosis

Fungal Neurotoxins and ALS

Excitotoxicity and Huntington Disease

Excitotoxicity and Stroke

Excitotoxicity in HIV Associated Neurocognitive Disordders

Excitotoxicity and AIDS

Excitotoxicity and Neuroprotection in Spinal Cord Injury

Excitotoxicity in the Pathogenesis of Autism

Cancer-Mediated Excitotoxicity., Excitotoxicity and Depression

Lead and Excitotoxicity

Glutamate and Neurodegeneration in the Retina

Excitotoxicity and Epielpsy

Seizures, Neurotrophin, Neuronal Death

Neurodegenerative Aspets of Multiple System Atrophy

Excitotoxicity in Ischemia and Reperfusion Injury

Molecular, Cellular, and Behavioural Effects Produced by Perinatal Asphyxia: Neuroprotectants Targeting NMDA Receptor Signaling

Neuroprotective Strategies in Amyotrophic Lateral Sclerosis Modulation of Neurotransmitory and Neurotrophic Input to Motor Neurons

Neuroprotection in Demyelinating Diseases: The Therapeutic Potential of the Neurotrophins

p75NTR: A Molecule with Multiple Functions in Amyloid-beta

Metabolism and Neurotoxicity

Neurotrophins and ALS

Neurotrophic Factors & NeuroAIDS

Neuroprotection by Poly (ADP-Ribose) Polymerase 1 (PARP-1) Inhibition

Alzheimer's Disease and Neurotoxic Aspects

Stem Cell Therapies for Age Associated Neurodegeneration

Pathogenesis of Alzheimer's Disease

Experimental Approach to Alzheimer Disease

Potential Therapeutic Effects of Statins in Alzheimer's Disease

Excitotoxicity and Alzheimer's Disease: Treatment Challenges

Amyloid-beta, BDNF, and Mechanism of Neurodegeneration in Alzheimer's Diseases

Drug Treatments: hopes, challenges

Cannabinoids and Alzheimer's

Heavy Metal Neurotoxicity

Trimethyltin Neurotoxicity

Mn Neurotoxicity

MeHG

Cd Neurotoxicity

Fe Neurotoxicity

Organoselenium

Al Neurotoxicity

Se Neurotoxicity

Pb Neurotoxicity

Cuprizone modelin of Multiple sclerosis.

Notes:

Includes index.

Other Format:

Print version: Kostrzewa, Richard M. Handbook of Neurotoxicity

ISBN:

9783031150807