Pharmacological preconditioning and ischaemic postconditioning in experimental jejunal ischaemia in horses / Nicole Verhaar.

Format:

Book

Author/Creator:

Verhaar, Nicole, author.

Series:

Wissenschaftliche Reihe der Klinik für Pferde

Wissenschaftliche Reihe der Klinik für Pferde ; Volume 52

Language:

English

Subjects (All):

Horses--Diseases--Treatment.

Horses.

Physical Description:

1 online resource (147 pages)

Edition:

First edition.

Place of Publication:

Göttingen, Germany : Cuvillier Verlag, [2021]

Summary:

Strangulating obstruction of the small intestine in the horse is associated with a high mortality rate. Although many intestinal lesions can be treated surgically, more effective strategies are needed to decrease the occurrence of complications related to the intestinal segments that are not amenable to intestinal resection. The aim of this PhD was to determine the feasibility and effect of two novel treatment modalities in equine small intestinal ischaemia. Therefore, ischaemic postconditioning and pharmacological preconditioning with lidocaine and xylazine were investigated in two experimental in vivo studies. By evaluating different variables for intestinal ischaemia reperfusion injury by use of histomorphology, immunohistochemistry and biochemical analysis, the results of this study demonstrate the applicability of these treatments in experimental small intestinal ischaemia in horses.

Contents:

Intro

List of Abbreviations

1. Summary

2. Zusammenfassung

3. Introduction

3.1. Small intestinal strangulation in horses

3.2. Preconditioning

3.3. Postconditioning

3.4. Remote conditioning

3.5. Conditioning - the mechanism of action

4. Aims and Objectives

5. Manuscript I Preconditioning with lidocaine and xylazine in experimental equine jejunal ischaemia

5.1. Supplementary items

6. Manuscript II The effect of ischaemic postconditioning on mucosal integrity and function in equine jejunal ischaemia

Supplementary items

7. Manuscript III Ischaemic postconditioning reduces apoptosis in experimental jejunal ischaemia in horses

8. Manuscript IV Hypoxia Inducible Factor 1-alpha and 2-alpha distribution during experimental ischaemia of the equine small intestine

9. Discussion

9.1. Main findings

9.2. Interpretation of the results

9.3. Conclusions and future perspectives

10. References

131 11. Acknowledgements.

Notes:

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Includes bibliographical references.

ISBN:

9783736964334

3736964331

OCLC:

1256237511