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Metabolic engineering of Basfia succiniciproducens for the production of carbon-three compounds / Jonathan Thomas Fabarius.
- Format:
- Book
- Author/Creator:
- Fabarius, Jonathan Thomas, author.
- Language:
- English
- Subjects (All):
- Biochemical engineering.
- Physical Description:
- 1 online resource (145 pages)
- Edition:
- 1. Auflage.
- Place of Publication:
- Göttingen, Germany : Cuvillier Verlag, 2018.
- Summary:
- The recent rise of bio-succinic acid as an industrial platform chemical has brought the rumen bacterium Basfia succiniciproducens, a natural producer of this organic acid, into the focus of research. This work investigated the potential of B. succiniciproducens for the production of carbon-three chemicals from sugars. Beside the optimization of improved genetic tools, the C3 chemicals alanine, ?-alanine and 3-hydroxypropionate (3-HP) were targeted. A new alanine producer, B. succiniciproducens ALA-1, exhibited good performance in the bioprocess. The next step demonstrated the proof-of-concept for ?-alanine synthesis using the heterologous expression of aspartate 1 decarboxylase genes from Corynebacterium glutamicum or Vibrio natriegens. The expression of two additional genes enabled the de novo synthesis of up to 100 mg L-1 3-HP from glucose.
- Notes:
- Description based on print version record.
- ISBN:
- 9783736989139
- 373698913X
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