Developmental origins of health and disease / edited by Lucilla Poston, Keith M. Godfrey, Peter D. Gluckman, Mark A. Hanson.

Format:

• Book

Contributor:

• Poston, Lucilla, editor.
• Godfrey, Keith (Keith M.), editor.
• Gluckman, Peter D., editor.
• Hanson, Mark A., editor.

Series:

• Cambridge medicine (Series)
• Cambridge medicine

Language:

English

Subjects (All):

• Pathology.
• Developmental biology.
• Embryology, Human.
• Prenatal influences.
• Diseases--Causes and theories of causation.
• Disease susceptibility.

Physical Description:

1 online resource (xi, 226 pages) : digital, PDF file(s).

Edition:

Second edition.

Place of Publication:

Cambridge, United Kingdom ; New York, NY : Cambridge University Press, 2023.

Summary:

The concept of the early life developmental origins of health and disease (DOHaD) in adults has stimulated a new approach to understanding disease trajectories, with major public health implications. Indeed, the principle of the 'lifecourse of disease' now influences health policies internationally. Environmental influences during pregnancy and early life that affect lifelong health are well documented, but there is a new focus on the preconception period and the significance of paternal health on the fetus. This fully revised second edition highlights scientific and clinical advances in the field, exploring new understanding of mechanisms such as epigenetics and the increasingly recognised role of external influences, including pollution. The book is structured logically, covering environment, clinical outcomes, mechanisms of DOHaD, interventions throughout the lifespan and finally implications for public health and policy. Clinicians and scientists alike will improve their understanding of the developmental origins of health and disease with this essential text.

Contents:

• Overview and introduction to the 2nd edition of the Developmental origins of health and disease
• The evolutionary basis of developmental origins of health and disease
• Timing : critical DOHaD windows with lifelong effects
• Long-term effects of food insecurity and undernutrition in early life
• Short and long term effects of maternal obesity and dysglycaemia for women and their children
• Long-term DOHaD effects of prenatal maternal stress, anxiety and depression on offspring mental health outcomes
• Environmental exposures in early life : effects of air pollution, chemicals and climate change on human health and wellbeing
• Developmental programming and the microbiome : how the maternal environment and early life shapes the infant gut microbiome pathway(s) and risk of disease
• Exposures driving long-term effects of DOHaD effects : influence of assisted reproductive technologies
• Cardiometabolic and renal DOHaD outcomes in offspring of complicated pregnancy
• Development origins of chronic respiratory diseases
• Early life adversity and female reproductive outcomes : how growth, diet and nutrition impact reproductive function and accelerated reproductive aging
• Developmental programming of ageing induced by poor maternal nutrition : evidence from rodent studies
• Visualizing structural underpinnings of DOHaD
• Molecular/epigenetic mechanisms of DOHaD
• The role of the placenta in the developmental origins of health and disease (DOHaD)
• DOHaD interventions in pregnancy; an oversight and perspective
• Do nutritional interventions/exposures in infants and children aged up to 3 years prevent overweight and obesity?
• Education and science communication : translation of DOHaD evidence for health benefit
• DOHaD : engaging with new global issues to inform policy.

Notes:

• Title from publisher's bibliographic system (viewed on 07 Dec 2022).
• Includes bibliographical references and index.

ISBN:

• 1-009-27226-8
• 1-009-27228-4
• 1-009-27225-X