PARKINSON'S AND ALZHEIMER'S TODAY [electronic resource] : about neurodegeneration and its therapy.

Format:

Book

Author/Creator:

Klimaschewski, Lars P.

Language:

English

Genre:

Electronic books.

Physical Description:

1 online resource

Place of Publication:

[S.l.] : SPRINGER-VERLAG BERLIN AN, 2023.

Contents:

Intro

Preface

Contents

1 Introduction to Brain Development: Why do We Need so Many Nerve Cells?

1.1 Neurons and Glia in the Central Nervous System

1.2 What Happens During Brain Development?

1.3 Evolutionarily Old Brain Parts are Simpler in Structure than the Neocortex

1.4 What Distinguishes the Left from the Right Brain?

1.5 Brain Development in Childhood and Adolescence

1.6 The Child's Brain is Enormously Plastic and can Still Heal

1.7 Is a Large Brain "Smarter" than a Small One?

1.8 Absolute and Relative Brain Weight

1.9 With the Second Evolutionary Leap, Our Brain Reaches its Maximum Size

1.10 Neural Stem Cells Remain Capable of Dividing for a Long Time

1.11 The Frontal Lobe is Especially Important for Higher Brain Functions

1.12 The Prefrontal Cortex Encodes Human Specific Properties

1.13 Brain Performance in Comparison

Further Reading

2 Aging and Neurodegenerative Diseases: Why do Nerve Cells Die?

2.1 The Normal Aging Process

2.1.1 Mechanisms of Cellular Aging

DNA Telomeres Determine the Number of Cell Divisions

Aging Cells Maintain a Chronic Inflammation

The Importance of Protein Homeostasis for Cellular Aging

Self-cleaning of Nerve Cells

Two Sides of a Coin: Oxygen Radicals

Endogenous Radical Scavengers Protect Our Nerve Cells

Chronic Inflammatory Processes in the Brain

2.1.2 Neuronal Cell Death

How do neurons die?

2.1.3 Blood Supply of the Aging Brain

Barrier Disorders are Not Uncommon in the Elderly

2.2 Parkinson's Disease

2.2.1 General Pathomechanisms

The Problem with Parkinson's Begins in the Lower Brainstem

2.2.2 Special Morphology of Affected Neurons

Special Requirements for Highly Branched Neurons

Many Amine-releasing Neurons are Constantly Active and Therefore More Easily Stressed

2.2.3 Specific Causes of Parkinson's Disease

2.2.4 Alpha-synuclein: A Key Protein in Parkinson's Disease

Fibrils Are More Dangerous Than Aggregates

Aggregates Are Not Only Found in Nerve Cells

2.2.5 The Prion Theory of Parkinson's Disease

Cranial Nerves Transport Pathological Proteins into the Brain

The Difficulties of a Clear Pathogenesis of Parkinson's Disease

2.3 Dementia and Alzheimer's Disease

2.3.1 How Does Alzheimer's Disease Manifest Itself?

2.3.2 General Pathomechanisms

ISBN:

9783662663691

3662663694

OCLC:

1352795909

Access Restriction:

Restricted for use by site license.