Metabolism and epigenetic regulation : implications in cancer / Tapas Kumar Kundu, Chandrima Das, editors.

Format:

Book

Contributor:

Das, Chandrima, editor.

Kundu, Tapas Kumar, editor.

Series:

Sub-cellular biochemistry ; Volume 100.

Subcellular Biochemistry ; Volume 100

Language:

English

Subjects (All):

Cancer--Genetic aspects.

Cancer.

Genetic regulation. .

Epigenetics. .

Physical Description:

1 online resource (622 pages)

Place of Publication:

Cham, Switzerland : Springer, [2022]

System Details:

Mode of access: World Wide Web.

Summary:

Metabolic programs of individuals are key determinants for disease susceptibility and immune response. This book, edited by experts in the field, summarizes epigenetic signaling pathways that regulate metabolic programs associated with cancer and cancer-related secondary diseases. The first part of the book highlights key metabolic pathways that are implicated in cancer and provides a comprehensive overview on the carbohydrate, protein, lipid, amino- and nucleic acid metabolic pathways that are deregulated in cancer. Special attention is paid to the altered tumor micro-environment that is influenced by the metabolic milieu. Furthermore, the fundamental relationship between the cellular metabolic environment and cell death-mediated autophagy is discussed. The second part of the book covers our understanding of the fundamental epigenetic regulations that are implicated in controlling the metabolic programs in cancer cells. Many aspects of epigenetic regulation of non-coding RNAs as well as DNA/RNA methylation, which influencing metabolic homeostasis in cancer, are discussed in detail. Special emphasis is placed on the epigenetic regulation of the amino acid, glucose/carbohydrate metabolism and epigenetic regulation during hypoxia and its connection to cancer. Last but not least, the third part of the book covers small molecule modulators of histone modifying enzymes, which can be used as therapeutic tools. The readers learn about the cross-talk between epigenetics and immunometabolims, as well as the epigenetic regulation of oncometabolites to combat cancer. Given its scope, the book will appeal to a broad readership interested in epigenetic, cancer and metabolic research.

Contents:

Intro

Foreword

Preface

Contents

Part I: Regulation of Key Metabolic Pathways in Cancer

Chapter 1: Reprogramming Carbohydrate Metabolism in Cancer and Its Role in Regulating the Tumor Microenvironment

Introduction

Molecular Cues Influence Metabolic Phenotype in Different Cancers

Role of Hypoxia in Tumor Microenvironment

Metabolic Adaptation Due to Hypoxia in the Tumor microenvironment

Tumor Microenvironment Associated Cells

Role of Oncogenes and Tumor Suppressors in Metabolic Reprogramming in Cancer

Hormone-Regulated Metabolic Alterations

Carbohydrate Metabolism Plays a Key Role in Acquisition of Different Cancer Hallmarks

Proliferation

Bioenergetics

Macromolecule Biosynthesis

Redox Balance

Angiogenesis

Invasion and Metastasis

Epithelial to Mesenchymal Transition (EMT)

Intravasation and Circulating Tumor Cells

Extravasation and Colonization in the Metastatic Niche

Immune Escape

Escaping Cell Death and Acquiring Resistance

Epigenetic Regulation in Reprogramming Carbohydrate Metabolism in Cancer Cells and Tumor Microenvironment

Epigenetic Regulation of Metabolic Genes and Their Regulators Impacting Cancer Cells

DNA Methylation

Histone and Non-Histone Protein Modification

Non-Coding RNAs

Reliance of Tumor Microenvironment Sustenance on Epigenetic Regulation

Metabolites Dictating Epigenetic Landscape Impact Cancer Progression

Metabolites Serving as Coenzymes or Cofactors

SAM Regulates DNA and Histone Methylation

Acetyl Co-A Contributes to Histone Acetylation

NAD+ and α-KG Regulates Histone Deacetylation and Demethylation

Oncometabolites Regulating Metabolic Enzymes

Nuclear Metabolites Acting As a Source of Epigenetic Co-Factors

Therapeutic Strategies Targeting Epigenetics-Metabolism Crosstalk in Cancer

Epi-Drugs.

Tumor Metabolite Inhibitors

Conclusion: Challenges and Future Perspectives

References

Chapter 2: Iron in Cancer Progression: Does BACH1 Promote Metastasis by Altering Iron Homeostasis?

Iron Is High in Cancer Cells

The Regulation of Iron in Cancer Cells

Possible Roles for Iron in Cancer Cells

BACH1 Promotes Progression of Diverse Types of Cancers

Does BACH1 Regulate Iron in Cancer Cells?

Transcription Factor-Based Research into Cancer Cell Properties

Chapter 3: Regulation of Lipid Metabolism Under Stress and Its Role in Cancer

Impact of Metabolic Stress on Lipid Metabolism in Cancer Cells

Effect of Hypoxia on Lipid Metabolism in Cancer Cells

Effect of Nutrient and Lipid Deprivation on Lipid Metabolism in Cancer Cells

Combinatorial Effect of Hypoxia and Nutrient Deprivation on Lipid Metabolism in Cancer Cells

Impact of Metabolic Stress on Lipidomic Profiles in Cancer Cells

Lipid/Lipidomic Profiles in Tumor Tissues and Tumor Spheroids

Targeting Lipid Metabolism for Cancer Therapy

Conclusions &amp

Future Perspectives

Chapter 4: Role of the Histone Acetyl Transferase MOF and the Histone Deacetylase Sirtuins in Regulation of H4K16ac During DNA...

MOF

SIRTUINS

Histone H4 Lysine 16 Acetylation (H4K16ac) in DNA Damage Repair

SIRTUINS Influence on Metabolic Regulation and Cancer

Connection Between Pre-Existing Histone Modifications and the DNA Damage Response and Repair in the Context of Cancer

Recruitment of Repair Proteins at DSBs Correlates with H4K16ac Status

MOF Suppresses DNA Replicative Stress by Facilitating Resolution of Stalled Replication Forks

Role of H4K16ac in Aging

Conclusion

Chapter 5: Autophagy in Cancer: A Metabolic Perspective

Introduction.

Autophagy: A Mechanism of Cellular Defense

Epigenetic Regulation of Autophagy

Autophagy in Cancer

Autophagy and Cancer Therapy

Enhancement of Effectiveness of Anticancer Therapies by Inhibiting Autophagy

Enhancement of Effectiveness of Anticancer Therapies by Promoting Autophagy

Autophagy and Metabolism Crosstalk

Epigenetic Regulation of Metabolic Pathways and Its Implication in Autophagy

Conclusion/Future Perspectives

Part II: Epigenetic Regulation of Cellular Metabolic Pathways

Chapter 6: Long Non-coding RNAs, Lnc(ing) RNA Metabolism to Cancer Biology

Origin and Development

Concepts and Facts

Functional Roles of LncRNA

Major Long Non-coding RNAs

Regulatory Roles

Association with RBPs

DNA Damage Response (DDR)

Maintenance of Chromatin States

Transcription

Post-transcription

Post-translational

LncRNA, Dual Regulators of Signalling Pathways in Cancer

LncRNAs Are Involved in Different Steps of the Signalling Cascade

Routes Through Which LncRNAs Regulate Signalling Pathways

Signalling Pathways Regulated by LncRNA: Building Blocks in Cancer Biology

LncRNA and Wnt Signalling

LncRNA and TGF-Beta Signalling

LncRNA and JAK-STAT Pathway

LncRNA and PI3/AKT Pathway

LncRNA and MAPK/ERK Signalling

LncRNA as Tumour Suppressors

GAS5

MT1JP

LET

MALAT1

MEG3

XIST

LncRNAs as Therapeutic Targets

Nucleic Acid Modulators of LncRNA

Small Molecule Modulators of LncRNA

Future Prospects

Chapter 7: Modulation of DNA/RNA Methylation Signaling Mediating Metabolic Homeostasis in Cancer

Nucleic Acid Methylation

The Writers and Erasers of DNA Methylation

Cellular Function of DNA Methylation

RNA Methylation

The Writers and Erasers of m6A RNA Methylation.

Cellular Function of m6A RNA Methylation

Metabolic Reprogramming of Cancer Cells

Nucleic Acid Methylation and Tumor Metabolism

DNA Methylation and Tumor Metabolism

Glucose Metabolism

Lipid Metabolism

Amino Acid Metabolism

Nucleotide Metabolism

RNA Methylation and Tumor Metabolism

Amino Acid and Nucleotide Metabolism

Crosstalk Between Methylome and Metabolome: A Target for Therapeutics

Summary and Future Perspectives

Chapter 8: Nutritional Epigenetics: How Metabolism Epigenetically Controls Cellular Physiology, Gene Expression and Disease

Nutritional Requirements of the Cell: Amino Acids, Vitamins, and Minerals

Metabolism and Epigenetics

S-Adenosyl Methionine (SAM) and the Methyl Cycle: Methylation of Histones and DNA

Flavin Adenine Dinucleotide (FAD), 2-Oxoglutarate-Dependent Demethylases

Acetyl-CoA and Histone Acetylation

NAD+ and Histone Deacetylation

Metabolic Regulation of Disease Through Epigenetic Route

Fetal Reprogramming

Cardiovascular Disease (CVD)

Obesity and Type 2 Diabetes

Alzheimer´s Disease

Cancer

Chapter 9: Epigenetic Reprogramming of the Glucose Metabolic Pathways by the Chromatin Effectors During Cancer

Role of Glucose Metabolism in Cancer Manifestation

Normal Cells: Glycolysis and TCA Cycle Are Balanced

Cancer Cells: Energy Production Shifts to Glycolysis-Warburg Effect

Deregulation of Glucose Metabolism in Cancer: Cause and Effects

Strategy of Cancer Cells Beyond Warburg Effect for Their Better Survival

Glycolysis and TCA Cycle Intermediates Help Cancer Cells for Biomass Production

Epigenetic Influences on Glucose Metabolism That Reprogram Cancer Cells Towards Survival.

Metabolic Intermediates and Their Connection to Epigenetic Regulation

S-Adenosyl Methionine (SAM)

Acetyl CoA

Nicotinamide Adenine Dinucleotide (NAD+)

Tetrahydrofolate (THF)

Flavin Adenine Dinucleotide (FAD)

Other Metabolites for Non-canonical Histone Modifications

Acyl-coA

UDP-N-acetylglucosamine (UDP-GlcNAc)

Monoamines

Oncometabolites

Different Epigenetic Reader Domains and Their Functions

Methylation Readers

Lysine Methylation

Arginine Methylation

Acetylation Readers

Phosphorylation Readers

Ubiquitination Readers

Reader of H2A Ubiquitination

Reader of H2B Ubiquitination

Reader of H3 and H4 Ubiquitination

SUMOylation Readers

Mechanisms of Reprogramming the Metabolic Landscape Through Epigenetic Regulators

TRIM24

Mechanism of Action

Glucose Uptake

Glycolysis

TCA Cycle

UHRF1

Gluconeogenesis

Glucose Uptake and Glycolysis

PHF20L1

Hypoxia Response

ZMYND8

Mechanism of Action and Role in Hypoxia Response

TCF19

Glycolysis and OXPHOS

Methods to Determine the Metabolic Aberrations During Glucose Metabolism due to Alteration in Transcription Programs

Glucose Sensing

Indirect Glucose Uptake measurements:

3-O-methylglucose (3-MG)

2-deoxy-D-glucose (2-DG)

2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose (2-NBDG)

Direct Glucose Uptake Measurements

3-Bromopyruvate

Oxidative Stress

ROS Assays

Direct Mode of ROS Measurements

Indirect Mode of ROS Measurements

RNS Assays

Glycolysis/TCA Cycle

Lactate Production Assay

Extracellular Acidification Rate Measurements

Gluconeogenesis Assays

Oxidative Phosphorylation

Mitochondrial Membrane Potential Measurements.

Oxygen Consumption Rate Measurements.

Notes:

Includes bibliographical references and index.

Description based on print version record.

Other Format:

Print version: Kundu, Tapas Kumar Metabolism and Epigenetic Regulation: Implications in Cancer

ISBN:

3-031-07634-6