Green sustainable process for chemical and environmental engineering and science : solvents for the pharmaceutical industry / edited by Inamuddin [and three others].

Format:

Book

Contributor:

Inamuddin, 1980- editor.

Language:

English

Subjects (All):

Pharmaceutical chemistry.

Solvents.

Green chemistry.

Physical Description:

pages

Edition:

1st ed.

Other Title:

Solvents for the pharmaceutical industry

Place of Publication:

Amsterdam, Netherlands : Elsevier, [2021]

Summary:

Green Sustainable Process for Chemical and Environmental Engineering and Science: Solvents for the Pharmaceutical Industry aims at providing a detailed overview of applications of green solvents in pharmaceutical industries.

Contents:

Intro

Green Sustainable Process for Chemical and Environmental Engineering and Science: Solvents for the Pharmaceutical Industry

Copyright

Contents

Contributors

Chapter 1: Vegetable oils as green solvents in the pharmaceutical industry

1. Introduction

2. Vegetable oil or vegetable oil-derived solvents

3. Vegetable oil-based drug delivery systems

4. Carotenoids

5. Biopolymers

6. Conclusions

References

Chapter 2: Supercritical fluids (SCFs) as solvents in the pharmaceutical industry

2. Fundamentals of particle formation approaches with function of supercritical fluids (SCFs) as ``solvent´´

2.1. Rapid expansion of supercritical fluids (RESS)

2.2. Rapid expansion of supercritical solution into a liquid solvent (RESOLV)

2.3. Rapid expansion of supercritical solution into an aqueous solution (RESSAS)

2.4. Rapid expansion of supercritical solution with solid cosolvent (RESS-SC)

2.5. Rapid expansion of supercritical solution with a non-solvent (RESS-N)

3. Effect of operating parameters on active pharmaceutical ingredients (APIs) particle formation

3.1. Extraction pressure

3.2. Preexpansion pressure

3.3. Extraction temperature

3.4. Preexpansion temperature

3.5. Postexpansion temperature

3.6. Amount of cosolvent

3.7. Injection flow rate

3.8. Spray distance

3.9. Concentration of feed

3.10. Nozzle effective diameter and nozzle length

3.11. Type of nozzle

4. Application of supercritical fluids (SCFs) as ``solvents of precipitation´´ in active pharmaceutical ingredients (APIs ...

5. Limitation of RESS and its variations (RESOLV, RESSAS, RESS-N, RESS-SC) in the processing of active pharmaceutical ing ...

6. Recent modifications on RESS and its variations (RESOLV, RESSAS, RESS-N, RESS-SC).

6.1. Input of feed, extraction vessel and expansion vessel

6.2. Sampling method

6.3. Using other SCFs

6.4. Combinational sc-CO2 system of SAS and RESSAS

7. Conclusion

Acknowledgment

Chapter 3: Ionic liquids as green solvents in the pharmaceutical industry

2. Ionic liquids solvent as well as physicochemical effects

3. Significance of imidazolium centered ILs as green solvent

4. Quaternization reactions

5. Anion exchange

6. Research based on pharmaceuticals

7. Role of ILs as dynamic pharmacological components

8. Impact of ionic liquids in drug delivery method

9. Crystallization technique using ionic liquids

10. Utilization of ILs with popular diverse fields

11. Chemical handling technique

12. Petroleum industry

13. Other applications

14. Conclusion

Acknowledgments

Chapter 4: Green solvents for drug synthesis

1. Pharmaceutical drugs

1.1. Prodrugs

2. Role of solvents in drug synthesis

2.1. Water as a reaction solvent

2.1.1. Water as a medium for drug synthesis

2.2. Ionic liquids

2.2.1. First-generation ionic liquids

2.2.2. Second-generation ionic liquids

2.2.3. Third-generation ionic liquids

2.3. Role of ionic liquids in drug development

2.3.1. Nonsteroidal antiinflammatory drugs

2.3.2. Antimalarial drugs

2.3.3. Antibiotic drugs

2.3.4. Antituberculosis drugs

2.3.5. Antifungal drugs

2.3.6. Anti-Alzheimer drugs

2.3.7. Antiviral drugs

2.4. Active pharmaceutical ingredients-ionic liquids

2.5. Deep eutectic solvents

2.5.1. DES in drug delivery system

Ibuprofen-based DDS

Itraconazole-based DDS

Antirheumatoidal-based DDS

Protein-based DDS

Phospho-lipid-based DDS

Polymer-based DDS

2.6. Supercritical fluids

2.6.1. Role of supercritical fluids in drug solubility.

Supercritical carbon dioxide

SC CO2 role in drug development

Chapter 5: Green solvents in the biotechnology-based pharmaceutical industry

1. Ecological thinking: How it starts?

2. Green chemistry and green solvents: Definitions

3. How can Biotech-Pharma industries make the world greener?

4. Biocatalysts

5. Green chemistry and chromatographic ligand synthesis

Chapter 6: Biosolvents as green solvents in the pharmaceutical industry

2. Bio-based alcohols

2.1. Methanol

2.2. Ethanol

2.3. Propanol

2.4. Butanol

2.5. Glycerol-based solvents

2.6. Furfuryl alcohol and their derivatives

3. Furans and other heterocyclic bio-based solvents

3.1. Furan derivatives

3.2. Piperidine

3.3. 2-Methyltetrahydrofuran

4. Carbonyl compounds as biosolvents

4.1. Levulinic acid

4.2. γ-Valerolactone

4.3. Ethyl lactate

4.4. Cyrene as a bio-based solvent

4.5. Other carbonyl derivatives as biosolvents

5. Bio-based amines

6. Deep eutectic solvent

7. Ionic liquids

8. Miscellaneous

9. Conclusion and future perspectives

Chapter 7: Case studies of green solvents in the pharmaceutical industry

2. Conventional extractions with organic solvents

3. Supercritical CO2 extraction

4. Case studies for spilanthol obtention

5. Conclusion

Chapter 8: Application of supercritical technology in the production of dietary supplement based on plant extracts

2. Dietary supplement

3. Plant extracts

3.1. Bioactive compounds used in dietary supplements

3.1.1. Carotenoids

3.1.2. Phenolic compounds

3.1.3. Fatty acids

4. Techniques for extraction of bioactive compounds from plants

4.1. Supercritical fluid extraction.

5. Nanotechnology

5.1. Nanoencapsulation

5.1.1. Techniques of nanoencapsulation using supercritical CO2

Supercritical fluid extraction of emulsions

6. Conclusion

Chapter 9: Ethyl lactate as a green solvent in the pharmaceutical industry

2. Properties of ethyl lactate

3. Production of ethyl lactate

4. Pharmaceutical applications of ethyl lactate

4.1. Extraction, dissolution, and dispersion of bioactive compounds

4.2. Dry skin disorders and cosmetics

4.3. Topical therapy, stereochemistry, and mineral lactate formulations

4.4. Controlled drug delivery system and diverse application

Further reading

Chapter 10: Current status of solvents used in the pharmaceutical industry

1. Solvents and their types

2. Synthesis of solvents

2.1. Synthesis of green solvent (ethyl lactate) from rice straw

2.1.1. Procedure

2.1.2. Hindrance by side reactions

2.1.3. Catalytic experiments

2.2. Formation of an octanoic acid-based supramolecular solvent (SUPRAS)

2.3. Production of n-butanol and acetone by Clostridium acetobutylicum

2.4. Water as pharmaceutical solvent

2.5. Synthesis of green solvents from plants

2.6. Bio-based green solvent disulfide free of any catalyst and additive

2.7. Solvents derived from biomass

3. Properties of solvents

3.1. Natural deep eutectic solvents

3.1.1. Properties of natural deep eutectic solvents (NDES)

3.2. Organic solvents

3.2.1. Properties of organic solvents

3.3. Ionic liquid solvents

3.3.1. Properties of ionic solvents

3.4. Cyclopentyl methyl ether solvents (CPMEs)

4. Role of solvents in pharmaceutical industries

4.1. Role of solvents

4.2. Deep eutectic solvents (DES)

as excipients enhances the bioavailability of orally administered protein active pharm.

4.3. Intermediate of pharmaceutical solvents: Their semiempirical models mediated solubility in organic solvents

4.4. Antisolvent crystallization technique in the pharmaceutics

4.5. Environmental impact of organic solvents used in pharmaceuticals

5. Trends of solvents used in the pharmaceutical industry

5.1. Trends of organic solvents

5.1.1. Residual solvents (RSs)

5.2. Trends of green solvents in the pharmaceutical industry

5.2.1. Deep eutectic solvents (DES)

5.2.2. Hydrophobic deep eutectic solvents (HDES)

5.2.3. Therapeutic deep eutectic solvents (THEDES)

Chapter 11: Green solvents for qualitative pharmaceutical analysis

1. Solvents

2. Green solvents

3. Properties of green solvents

4. Green solvents in the pharmaceutical industry for purification and production

5. Importance of green solvents

6. Role of green solvents in pharmaceuticals

7. Environment friendly green solvents from alternative sources

8. Green solvents in the pharmaceutical industry for medicine production

9. Role of green solvents in pharmaceutical applications

10. Green solvents in the pharmaceutical industry for medicine purification

11. Green solvents in purification of pharmaceutical products

11.1. Purification of sildenafil citrate

11.2. Purification of sertraline

11.3. Purification of ABT-546

11.4. Purification of LY300164

11.5. Purification of celecoxib

11.6. Purification of quinapril

11.7. Ionic green liquids in medicine purification

12. Advances in synthesis and application of green solvents in pharmaceutical products

Chapter 12: Cyrene as a green solvent in the pharmaceutical industry

2. Solvent selection

Criteria for a safe solvent

2.1. The twelve principles of green chemistry

2.1.1. Criteria for a green solvent.

2.1.2. Uses of solvent in the pharmaceutical industry.

Notes:

Includes bibliographical references and index.

Description based on print version record.

Description based on publisher supplied metadata and other sources.

ISBN:

9780128218990

0128218991

9780128218853

0128218851

OCLC:

1224362528