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Nuclear oncology : from pathophysiology to clinical applications / Duccio Volterrani, Paola A. Erba, H. William Strauss, Giuliano Mariani, Steven M. Larson, editors.
- Format:
- Book
- Language:
- English
- Subjects (All):
- Cancer--Radionuclide imaging.
- Cancer.
- Cancer--Radiotherapy.
- Nuclear medicine.
- Genre:
- Electronic books.
- Physical Description:
- 1 online resource (xl, 2254 pages) : illustrations (chiefly color)
- Edition:
- Third edition.
- Place of Publication:
- Cham : Springer, [2022]
- Summary:
- This book discusses the role of nuclear medicine in the diagnosis, staging, and treatment of patients with specific cancers. It presents the incidence, pathophysiologic and clinical aspects of the disease, the use of nuclear imaging in diagnosis, staging requirements, management of specific tumors, and surveillance after primary treatment of cancers. It addresses the various diagnostic/therapeutic options that are currently available or are most likely to become available in the near future according to a prioritized approach, thereby keeping to a minimum the number of diagnostic imaging procedures the patient is expected to undergo. Topics include basic science, clinical applications, radionuclide therapy, radioguided surgery, heart disease in the cancer patient, and adverse effects of cancer therapy. Each clinical chapter discusses the radionuclide procedures within an integrated framework, thereby identifying the information required for effective treatment of specific tumors. The book concludes with a series of updated cases that define and expand the didactic material in the clinical application chapters. Thoroughly updated and revised, the third edition incorporates new clinical evidence validating the use of radionuclides for diagnosis and therapy in oncology, new radiotracers, and the growing integration of imaging modalities into different types of hybrid imaging. With contributions from a group of internationally distinguished practitioners, Nuclear Oncology: From Pathophysiology to Clinical Applications, Third Edition, is a valuable reference for nuclear medicine physicians, radiologists, medical and surgical oncologists, and other clinicians involved in the care and management of cancer patients.
- Contents:
- Intro
- Preface to the Third Edition
- Preface to the Second Edition
- Preface to the First Edition
- Acknowledgments
- Contents
- About the Editors
- Contributors
- Part I: Basic Science
- 1 Cancer Biology of Molecular Imaging
- Introduction
- The Evolving Context of Molecular Imaging: Cancer Genomics and Epigenomics
- Hallmarks of Cancer
- The Tumor Mass
- Imaging the Tumor Mass
- Neovasculature
- Hypoxia
- Cellular Constituents and Cell-Cell Synergism of the Tumor Mass
- Immune Cell Cancer Immunotherapy
- Immune Checkpoint Blockade
- Imaging the Immune T Cells
- The Metastatic Process
- Imaging the Cancer Cell
- Total Lesion Glycolysis (TLG) as a Predictive Marker of Prognosis and Tumor Responsiveness
- Proliferation Imaging
- 18F-FLT Imaging of Proliferation After Chemotherapy
- The Cancer Biology of Cellular Lineage Plasticity and the Nuclear Imaging Phenotype
- Lineage Plasticity and Relevance to Molecular Imaging in Prostate Cancer
- Molecular Imaging of Fibroblast-Activating Protein, a Molecule Expressed in Tumor Stroma
- Oncogene and Non-oncogene Addiction
- Examples of Imaging the Action Driver Mutations in Cancer Cells Indirectly Through the Effects on Metabolism
- BRAF Inhibition in Advanced Melanoma with V600E Mutation
- Inhibition of MEK, a Downstream Signal Transduction Molecule in the RAS/BRAF/ERK Pathway, Can Reverse 131I Resistance in Patie...
- Future Applications
- References
- 2 Principles of Molecular Targeting for Radionuclide Therapy
- The Choice of Radionuclide
- Nuclear Properties
- Radioisotope Production
- Theranostics
- Instrument Resolution and Biological Resolution
- Radiobiological Properties Affecting the Choice of Radionuclide
- Radiation Microdosimetry and Particle Range
- The Choice of a Chemical Platform
- Salts and Covalent Bonds
- Chelating Agents
- Coordination of Tc(V) and Re(V)
- Nanoparticles
- Location of the Target: The Challenges of Designing Radiotracers for Intracellular Compartments
- Critical Subcellular Sites of Interaction with Ionizing Radiation (Direct Effects)
- Radiation-Induced Biological Bystander Effects (RIBBEs)
- Critical Subcellular Sites of Interaction with Ionizing Radiation (Indirect Effects)
- Cell Membrane
- Mitochondria
- Transfectant Mosaic Spheroid Model
- Transfectant Mosaic Xenograft Model
- Media Transfer
- LET and Dose Rate
- Conclusion
- 3 Single-Photon Emitting Radiopharmaceuticals for Diagnostic Applications
- 99mTc-Labeled Radiopharmaceuticals
- 99mTc-Sodium Pertechnetate
- 99mTc-Diphosphonates
- 99mTc-Radiocolloids
- 99mTc-Magroaggregated Albumin
- 99mTc-Sestamibi
- 99mTc-Tetrofosmin
- 99mTc-EDDA/HYNIC-Octreotide or Octreotate
- Lung Ventilation Radiopharmaceuticals
- 99mTc-DTPA
- 99mTc-Technegas
- Xenon-133
- Xenon-127
- Notes:
- Included index.
- ISBN:
- 9783031054945
- 3031054946
- OCLC:
- 1347020732
- Access Restriction:
- Restricted for use by site license.
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