Basic pharmacokinetics and pharmacodynamics : an integrated textbook and computer simulations / edited by Sara E. Rosenbaum.

Format:

Book

Author/Creator:

Rosenbaum, Sara (Sara E.), author, editor.

Language:

English

Subjects (All):

Computer simulation.

Pharmacokinetics.

Physical Description:

1 online resource (757 pages) : illustrations

Edition:

Second edition.

Place of Publication:

Hoboken, New Jersey : John Wiley & Sons, Incorporated, [2017]

Summary:

Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. • Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner • Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules • Features interactive computer simulations, available online through a companion website at: https://web.uri.edu/pharmacy/research/rosenbaum/sims/ • Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications • Reviews of the 1st edition: "This is an ideal textbook for those starting out ... and also for use as a reference book ...." (International Society for the Study of Xenobiotics) and "I could recommend Rosenbaum's book for pharmacology students because it is written from a perspective of drug action... Overall, this is a well-written introduction to PK/PD .... " (British Toxicology Society Newsletter)

Contents:

Introduction to pharmacokinetics and pharmacodynamics

Passage of drugs through membranes

Drug administration and drug absorption / Steven Sutton

Drug distribution

Drug elimination and clearance

Compartmental models in pharmacokinetics

Pharmacokinetics of an intravenous bolus injection in a one-compartment model

Pharmacokinetics of an intravenous bolus injection in a two-compartment model

Pharmacokinetics of extravascular drug administration / Steven Sutton

Introduction to noncompartmental analysis

Pharmacokinetics of intravenous infusion in a one-compartment model

Multiple intravenous bolus injections in the one-compartment model

Multiple intermittent infusions

Multiple oral doses

Nonlinear pharmacokinetics

Introduction to pharmacogenetics

Models used to predict drug-drug interactions for orally administered drugs

Introduction to physiologically based pharmacokinetic modeling

Introduction to pharmacodynamic models and integrated pharmacokinetic

pharmacodynamic models / Diane Mould and Paul Hutson

Semi-mechanistic pharmacokinetic

pharmacodynamic model / Diane Mould and Paul Hutson.

Notes:

Includes bibliographical references and index.

Description based on print version record.

ISBN:

9781119143185

1119143187

OCLC:

965779136