1 option
Managing immunotherapy related organ toxicities : a practical guide / Yinghong Wang, editor.
- Format:
- Book
- Language:
- English
- Subjects (All):
- Immunotherapy--Complications.
- Immunotherapy.
- Cancer--Treatment--Complications.
- Cancer.
- Immune complex diseases.
- Organs (Anatomy).
- Clinical toxicology.
- Genre:
- Electronic books.
- Physical Description:
- 1 online resource (333 pages)
- Place of Publication:
- Cham : Springer, 2022.
- Summary:
- Certain organ toxicities can be severe and life-threatening. Therefore, it is crucial to recognize these disease entities early on to provide prompt and effective treatments to improve the quality of patient care, and enable the continuation of cancer therapy long-term. A clinical handbook with a particular focus in this field is lacking. This handbook focuses on the comprehensive, systematic review of clinical aspects of immunotherapy-induced toxicities in 15 major organ systems. The organs covered include endocrine, eye, gut, heart, kidney, liver, lung, muscular-skeletal, neuro, pancreas and skin etc. A unique feature about this book is the inclusion of perspectives from Anesthesiology, Infectious Disease, and Pathology besides specific organ toxicity management. The contributors are a group of experts offering routine clinical care to patients with most complex and refractory toxicity conditions, conducting pioneering research, and providing the guidance for the clinical practice to the peers and trainees in the field. The topics of each chapter include incidence, clinical presentations, evaluation, management, and long term follow up of each disease entity. There is also a simplified management algorithm or table illustrated in each chapter as well as audio PowerPoint slide deck to provide straightforward general instruction on the evaluation and treatment.
- Contents:
- Intro
- Preface
- Introduction
- Contents
- Contributors
- Chapter 1: Anesthesia
- General Recommendations
- Organ-Specific Treatment Strategies
- References
- Chapter 2: Cardiology (Heart)
- Available Immune Checkpoint Inhibitors
- Cardiac Side Effect Profile of Immune Checkpoint Inhibitors
- Mechanisms of Myocardial Toxicity
- ICI-Associated Myocarditis
- Timing Onset of Myocarditis
- Diagnostic Testing Considerations in ICI-Associated Myocarditis
- Troponin
- Natriuretic Peptide
- Electrocardiogram (ECG)
- Echocardiography
- Cardiac Magnetic Resonance (CMR) Imaging
- Endomyocardial Biopsy (EMB)
- Management
- Advanced Management
- Conclusion
- Chapter 3: Dermatology (Skin)
- Epidemiology
- Clinical Characteristics
- Morbilliform/Maculopapular Rash (MPR)
- Pruritus
- Eczematous Dermatitis
- Urticaria
- Lichenoid/Lichen Planus-Like Eruption
- Psoriasiform Dermatitis
- Vitiligo
- Granulomatous Dermatitis
- Xerosis
- Autoimmune Bullous Disorders
- Severe Cutaneous Adverse Reactions
- Erythema Multiforme (EM)
- Neutrophilic Dermatoses
- Sweet's Syndrome (Acute Febrile Neutrophilic Dermatosis)
- Pyoderma Gangrenosum
- Follicular Eruptions
- Rheumatologic Disease
- Dermatomyositis and polymyositis
- Mucosal Toxicities
- Hair Toxicities
- Nail irCAEs
- Less Common irCAEs
- Grover's Disease
- Keratoacanthoma/Cutaneous Squamous Cell Carcinoma
- Evaluation
- Diagnostic Tests for Specific irCAEs
- Bullous Pemphigoid
- Dermatitis Herpetiformis
- Pemphigus Vulgaris-Like Lesions
- Rheumatologic Diseases
- Treatment
- Treatment Pearls
- Eczematous
- Lichenoid
- Psoriasiform
- Alopecia
- Mucosal Toxicities (Including Lichenoid Eruptions)
- Nail Toxicities
- Granulomatous
- SCARs
- Erythema Multiforme
- Sarcoidosis
- Treatment Recommendations
- Long-Term Complication and Follow-Up
- Chapter 4: Endocrine
- Checkpoint Inhibitor-Induced Hypophysitis
- Long-Term Complications and Follow-Up
- Thyroid Dysfunction
- Long-Term Complications and Follow-Up
- Primary Adrenal Insufficiency
- Clinical Presentation
- Checkpoint Inhibitor-Induced Diabetes
- Chapter 5: Gastroenterology (GI)
- Epidemiology and Risk Factors
- Type of ICI Agent
- Type of Cancer
- The Patient
- Clinical Presentation and Evaluation
- Clinical Evaluation
- Biochemical and Stool Evaluation
- IMC, Infections, and Its Management
- Imaging
- Endoscopic Evaluation
- Histologic Evaluation
- Notes:
- Treatment of IMC
- Includes bibliographical references and index.
- Online resource; title from PDF title page (SpringerLink, viewed September 19, 2022).
- Other Format:
- Print version: Wang, Yinghong. Managing Immunotherapy Related Organ Toxicities.
- ISBN:
- 9783031002410
- 3031002415
- OCLC:
- 1344158398
- Access Restriction:
- Restricted for use by site license.
The Penn Libraries is committed to describing library materials using current, accurate, and responsible language. If you discover outdated or inaccurate language, please fill out this feedback form to report it and suggest alternative language.