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Neurochemistry in clinical practice / Pradeep C. Bollu, editor.
- Format:
- Book
- Language:
- English
- Subjects (All):
- Neurochemistry.
- Brain--Effect of drugs on.
- Brain.
- Neuropsychopharmacology.
- Genre:
- Electronic books.
- Physical Description:
- 1 online resource
- Place of Publication:
- Cham, Switzerland : Springer, 2022.
- Summary:
- This book offers a comprehensive overview of the most important neurochemicals and approaches everything from the neurochemicals perspective. It attempts to integrate the biochemical pathways of synthesis and metabolism of these neurochemicals with the disease states and point out the avenues of diagnostic testing and therapeutic intervention. Each chapter focuses on a specific neurochemical and provides a brief history, the biochemical profile, metabolism, physiological functions, and the clinical aspects. The clinical part of each chapter includes a discussion on disease states with either increased or reduced activity of the neurochemical and either activation or inhibition of the relevant receptors. This book is targeted toward practitioners and students of neuroscience and is written to emphasize the importance of these neurochemicals in the brain. With this emphasis on background neurochemical processes, the readers will be pointed towards logical diagnostic studies, laboratory investigations, and therapies based on the neurochemical dysfunction that underlies various disease states.
- Contents:
- Intro
- Preface
- Acknowledgments
- Contents
- Contributors
- Chapter 1: Dopamine
- Introduction
- Physiology and Functions
- Metabolism: Synthesis and Degradation
- Dopamine Receptors
- Dopaminergic Pathways
- Dopamine, Parkinsonism, and DAT Scan
- Dopamine and Psychiatric Disease
- Tardive Dyskinesia
- Dopamine and Punding
- Dopamine and Restless Leg Syndrome
- Dopamine, Sleep, and Wakefulness
- Dopamine and Hypothalamus
- Drugs Associated with Dopamine
- Dopamine Precursor
- Levodopa
- Dopamine Agonists
- Vesicular Monoamine Transporter (VMAT) Depletors
- References
- Chapter 2: Serotonin
- History of Serotonin
- Neurochemical Profile
- Serotonin in the Brain
- Serotonin in the Periphery
- Raphe Nuclear System
- Serotonin Receptors
- Serotonin Metabolism
- Chemical Structure and Biosynthesis
- Serotonin Metabolism
- Medications Acting on Serotonin System
- Other Clinical Aspects
- Serotonin in Migraine
- Serotonin Effects on Heart
- Serotonin in Psychosis
- Serotonin Modulation in Obesity (Lorcaserin)
- Serotonin in Nausea/Vomiting
- Serotonin in Gut Motility
- Serotonin Syndrome
- Serotonin in RLS
- References
- Chapter 3: Adenosine
- Introduction
- Metabolism
- Receptors
- Alzheimer's Disease and Autism
- Sleep and Restless Leg Syndrome
- Psychiatric Conditions
- Epilepsy
- Ischemia
- Parkinson's Disease
- Huntington's Disease
- Multiple Sclerosis
- Adenosine Agonists
- Adenosine Antagonist: Caffeine
- Chapter 4: GABA
- History of GABA
- Neurochemical Profile of GABA
- GABA in Sleep
- GABA in Neuronal Inhibition
- GABA Receptors
- GABAA Receptor
- GABAB Receptor
- GABA Metabolism
- Medications Acting on the GABAergic System
- Benzodiazepines
- Barbiturates
- Sodium Oxybate
- Baclofen
- Other Clinical Aspects
- Antibody-Mediated Attack on GABA
- GABA Antagonism and Improvement in Alertness: Role of Flumazenil in Hypersomnia
- GABA in Restless Leg Syndrome (RLS)
- Chapter 5: Glutamate
- History
- Glutamate and Neural Plasticity
- Glutamate in Neurotoxicity
- Ionotropic Glutamate Receptors
- NMDA Receptors
- Non-NMDA Receptors
- Metabotropic Glutamate Receptors
- Glutamate Transporters
- The Glutamate-Glutamine Cycle
- GABA
- Medications
- Ketamine
- Memantine
- Riluzole
- Topiramate
- Felbamate
- Pregabalin
- Lamotrigine
- Perampanel
- Clinical Aspects
- Role of Glutamate in Epilepsy
- Role of Glutamate in Autoimmune Encephalitis
- Role of Glutamate in Stroke
- Role of Glutamate as a Dietary Toxin
- Role of Glutamate in Neurodegeneration
- Chapter 6: Glycine
- The Glycine Receptor
- The N-Methyl-D-Aspartic Acid Glutamate Receptor
- The Glycine Transporters Type 1 and 2 Receptors
- Neurotransmitter
- Potentiating Action at the NMDA Receptors
- The Role of Glycine Transporters
- Metabolism
- Notes:
- Includes index.
- Online resource; title from PDF title page (SpringerLink, viewed September 28, 2022).
- ISBN:
- 9783031078972
- 3031078977
- OCLC:
- 1344421958
- Access Restriction:
- Restricted for use by site license.
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