This handbook explains the application of nanoparticles in medical diagnosis and treatment. It is a ready reference on the subject, starting with the introduction to nanoparticles and progressing to synthetic procedures for nanotherapeutics, human disease diagnosis and nanocarrier-based drug delivery. The book also covers information about specific nanoparticle conjugates, in which nanoparticles are combined with drugs or nucleic acid strands (DNA, siRNAs, shRNAs, miRNAs) as well as topics of relevant to this field such as immunotherapy and vaccination development strategies. Each chapter also provides references for further reading. A Comprehensive Guide to Nanoparticles in Medicine is an ideal resource for scholars in medicine, pharmacology and technology who require an understanding to some basic facets of nanoparticles.

Contents:

Cover
Title
Copyright
End User License Agreement
Contents
Foreword
Preface
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
Acknowledgements
Introduction of Nanoparticles in Medicine
INTRODUCTION
REFERENCES
The Procedure of Synthesis of Nanoparticles Used as Diagnostics and Therapy Available till Date
CHEMICAL METHODS OF NANOPARTICLE SYNTHESIS
Co-Precipitation
Sol-Gel Method
Microemulsion Method
Hydrothermal Technique
Polyol Synthesis
Microwave Assisted Synthesis
Chemical Vapor Deposition (CVD) &
Chemical Vapor Synthesis (CVS)
Plasma Enhanced Chemical Vapor Deposition (PECVD)
PHYSICAL METHODS OF NANOPARTICLE SYNTHESIS
High Energy Ball Milling
Inert Gas Condensation
Physical Vapor Deposition
Laser Pyrolysis
Flame Spray Pyrolysis
Electrospraying
Melt Blending
BIO-ASSISTED METHODS
Biogenic Synthesis Using Microorganisms
Biogenic Synthesis Using Bio-molecules as the Templates
Biogenic Synthesis Using Plant Extracts
CONCLUSION
Recent Progress of Nanoparticles Used in the Diagnosis of Different Types of Diseases
NANOPARTICLE BASED DIAGNOSIS
Emission-Based Detection
Fluorescence-Based Detection
Colorimetric Detection
Microarray Detection
Magnetic-Based Detection
Magnetic Resonance Imaging (MRI)
Nuclear Magnetic Resonance (NMR)
Electrochemical-Based Detection
Gold Nanoparticles
Silver Nanoparticle
Quantum Dot Nanoparticles
Cerium oxide nanoparticles (CeO2 NPs)
Mercury Selenide Nanoparticles (HgSe NPs)
Copper-based Nanoparticles (CuNPs)
Plasmonics-Based Detection
Surface-Enhanced Raman Scattering (SERS)
Surface-Enhanced Infrared Absorption (SEIRA)
Metal Enhanced Fluorescence (MEF)
REFERENCES.
Drug Delivery through Nanoparticle in Treatment of Diseases
CHARACTERISTICS OF NANOPARTICLE FOR THE FABRICATION OF DRUG DELIVERY VEHICLE
Size of Nanoparticles
Surface Property of Nanoparticles
Drug Loading and Release From the Nanoparticle
APPLICATION OF NANOPARTICLES IN DRUG DELIVERY
Cancer Therapy
HIV and AIDS Treatment
Nutraceutical Delivery Through Nanoparticles
NANOCARRIERS FOR DRUG DELIVERY
Organic Polymer Based Nanocarriers
Chitosan
Alginate
Xanthan Gum
Cellulose
Liposomes
Dendrimers
Inorganic Nanoparticles
Carbon Nanotubes
Quantum Dots
Superparamagnetic Iron-Oxide Nanoparticles
Silica Nanoparticles
Nanoparticle-DNA Conjugate: The Treatment and Diagnostic Option for Future Cure of Diseases
DNA-NANOPARTICLE CONJUGATES IN NANOMEDICINE
DNA-Gold Nanoparticle Conjugate
Binding Between DNA and Gold Nanoparticle
Application of DNA-Gold Nanoconjugate in Nucleic Acid Detection
Application of DNA-Gold Nanoparticle for Colorimetric Detection of Miscellaneous Analytes
Application of DNA-Gold Nanoconjugate for Gene And Drug Delivery
DNA-Silver Conjugate Nanoparticle
Plasmonic Application of DNA-Silver Nanoconjugate
DNA-Magnetic Nanoparticle
Gene Therapy
Fluorescence Detection Method
DNA-Platinum and Palladium Nanoparticles
Electrochemical Detection
DNA Detection in Chip Based Microarrays
DNA-Quantum Dots Nanoconjugate
Biosensing Application
Gene Delivery and Therapeutics
DNA-Carbon Nanotubes
Chemical Biosensors
Detection of Nucleic Acid Sequence
Biological Transporters
DNA-Chitosan Nanoparticle
Nanoparticle Conjugated with siRNA for Treatment of Different Types of Disease Conditions
INTRODUCTION.
siRNAs as Potential Therapeutics
CHALLENGES IN DELIVERY OF SIRNA
Administrative Barrier
Vascular Barrier
Cellular Barriers
Immune Response and Safety
OVERCOMING THE MAJOR BARRIERS FOR SIRNA DELIVERY
Intravenous Administration
Optimization of the Size of the siRNA Nanocarrier
Endocytosis of siRNA-nanoparticle Conjugate
Overcoming the Immune Response
NANOPARTICLE IN SIRNA THERAPY
siRNA-silica Based Nanoconjugate
siRNA-metal and Metal Oxide Nanoconjugates
siRNA-carbon Based Nanoconjugates
siRNA-dendrimer Nanoconjugates
siRNA-polymer Nanoconjugate
siRNA-Cyclodextrin Nanoconjugate
siRNA-lipid Based Nanoconjugates
siRNA-hydrogel Nanoconjugate
siRNA-quantum Dot Nanoconjugate
shRNA-Nanoparticle Conjugate as a Therapeutic Option
SHRNA-NANOPARTICLE CONJUGATES
Inorganic Nanoconjugates
Organic Nanoconjugates
Polymeric Nanoconjugates
Other Nanoparticle Conjugates
miRNA and Nanoparticle Conjugate as a Future Therapeutic Approach
Tissue Specific Expression
Circulation miRNAs
THERAPEUTIC APPROACHES USING MIRNAS
miRNA Suppression Therapy
miRNA Replacement Therapy
CHALLENGES IN MIRNA BASED THERAPIES
Instability within Blood Vascular System
Reduced Intracellular Delivery
Off Target Effects
NANOPARTICLE ASSISTED MIRNA DELIVERY
Inorganic Nanoparticle Based Delivery of miRNA and Anti-miRNA
Gold Nanoconjugate
Graphine Nanoconjugate
Mesoporous Silica Nanoconjugate
Quantum Dot Nanoconjugate
Magnetic Nanoconjugate
Organic Nanoparticle Based Delivery of miRNA and Anti-miRNA
Chitosan Based Nanoconjugate
Lipid/liposome Based Nanoconjugate
Protein or Peptide Based Nanoconjugate
Aptamers Nanoconjugate.
Polymeric Nanoparticle Based Delivery of miRNA and Anti-miRNA
Polyethyleneimine Nanoconjugate
Dendrimer Nanoconjugate
PLGA Based Nanoconjugate
Cyclodextrin Nanoconjugate
CHALLENGES WITH RNA NANOTECHNOLOGY
Challenge in RNA Structure Prediction
Stability of the Nanoconjugate
In Vivo Half-life and Retention Time of the Nanoconjugate
Limited Carrying Capacity of the Nanoparticle
Scaling Up of the Conjugate
Hurdles in Endosomal Escape of the Payload
Nanoparticle Immunotherapy
NANOPARTICLES IN IMMUNOTHERAPY
Antigen Delivery by Nanoparticles
Adjuvant Delivery by Nanoparticles
Co-delivery of Antigen and Adjuvant by Nanoparticles
Activation of Dendritic Cells by Nanoparticles
Change of Tumor Microenvironment by Nanoparticles
Delivery of Antibodies by Nanoparticles
Gene Delivery by Nanoparticles
Cytokine Delivery by Nanoparticles
Therapeutic Cellular Engineering by Nanoparticles
Overcoming Immunosuppression by Nanoparticles
Immune Check Point Inhibition by Nanoparticles
Induced Immunogenic Cell Death by Nanoparticles
TYPES OF NANOPARTICLES IN IMMUNOTHERAPY
Organic Nanoparticles
Polymeric Nanoparticles
Nanoparticle Vaccines
CHARACTERIZATION OF NANOVACCINES
Size
Surface Charge
Shape
Hydrophobicity
Surface Modification
NANOPARTICLE VACCINES
IMMUNE STIMULATOR USING NANOCARRIER
Cytokines
Toll Like Receptor Agonists
Nucleic Acids
Conclusion
Glossary
ABBREVIATIONS
Subject Index
Back Cover.

Notes:

Description based on publisher supplied metadata and other sources.
Description based on print version record.
Includes bibliographical references.

ISBN:

9781681088358
1681088355

OCLC:

1260347526

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A Comprehensive Guide to Nanoparticles in Medicine / Rituparna Acharya.

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