Personalized drug screening for functional tumor profiling / Victoria El-Khoury, Tatiana Michel, Hichul Kim, Yong-Jun Kwon.

Format:

Book

Author/Creator:

El-Khoury, Victoria, author.

Michel, Tatiana, author.

Kim, Hichul, author.

Kwon, Yong-Jun, author.

Series:

Elements in Molecular Oncology, 2634-7490

Language:

English

Subjects (All):

Cancer--Chemotherapy.

Cancer.

Precision medicine.

Antineoplastic agents.

Physical Description:

1 online resource (22 pages) : digital, PDF file(s).

Edition:

1st ed.

Place of Publication:

Cambridge : Cambridge University Press, 2022.

Summary:

Despite considerable advances in our understanding of the biology that underlies tumor development and progression of cancer and the rapidly evolving field of personalized medicine, cancer is still one of the deadliest diseases. Many cancer patients have benefited from the survival improvements observed with targeted therapies but only a small subset of patients receiving targeted drugs experience an objective response. Because cancer is a complex and heterogeneous disease, the search for effective cancer treatments will need to address not only patient-specific molecular defects but also aspects of the tumor microenvironment. The functional tumor profiling directly measures the cellular phenotype, in particular tumor growth, in response to drugs using patient-derived tumor models and might be the next step toward precision oncology. In this Element, the authors discuss the personalized drug screening as a novel patient stratification strategy for the determination of individualized treatment choices in oncology.

Contents:

Cover

Title page

Copyright page

Personalized Drug Screening for Functional Tumor Profiling

Contents

1 Rationale for Functional Profiling in Oncology

2 Tumor Models in Drug Screening

2.1 Two-Dimensional versus Three-Dimensional Cultures

2.2 Patient-Derived Tumor Xenograft (PDX) Models

2.3 Organotypic Tumor Slices

2.4 Patient-Derived Tumor Spheroids and Organoids

3 Cell-Based Screening Platforms for Personalized Medicine

3.1 Three-Dimensional Bioprinting Platform

3.2 Micropillar-Based Cell Printing Platform

4 Drug Repurposing in Personalized Oncomedicine

5 Clinical Applications of Drug Screening in Oncology

6 Conclusions and Perspectives

References.

Notes:

Title from publisher's bibliographic system (viewed on 10 Jun 2022).

ISBN:

1-009-03689-0

1-009-03723-4

1-009-03787-0

OCLC:

1334604569