Allostery : Methods and Protocols / edited by Luisa Di Paola, Alessandro Giuliani.

Format:

Book

Contributor:

Di Paola, Luisa, Editor.

Giuliani, Alessandro, Editor.

SpringerLink (Online service)

Series:

Springer Protocols (Springer-12345)

Methods in molecular biology 1940-6029 ; 2253

Methods in Molecular Biology, 1940-6029 ; 2253

Language:

English

Subjects (All):

Proteins.

Protein Biochemistry.

Local Subjects:

Protein Biochemistry.

Physical Description:

1 online resource (XII, 274 pages) : 99 illustrations, 91 illustrations in color.

Edition:

1st ed. 2021.

Contained In:

Springer Nature eBook

Place of Publication:

New York, NY : Springer US : Imprint: Humana, 2021.

System Details:

text file PDF

Summary:

This volume explores the basic issues of "allostery" and "network" that are fundamental to studying this field. Chapters in this book look at how the basic "machine-like" proteins, that are similar to "human machines," need to be organized, architecturally, to relate to different organizational layers. Chapters cover topics such as methodological/computational factors focused on links between allostery and network formalism; the presence of oscillating modes transversing the structure and underlying network wiring of the allosteric process; the "action at distance" by transduction of signals across an organized network structure; and the P53 protein located at the cross-road of cell cycle regulation, genome integrity, and cancer development. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Allostery: Methods and Protocols is a valuable resource for any scientists and researcher interested in learning more about this developing field. .

Contents:

Allostery: The Rebound of Proteins

Disclosing Allostery Through Protein Contact Networks

Identification of Allosteric Effects in Proteins by Elastic Network Models

Locating and Navigating Energy Transport Networks in Proteins

Probing Allosteric Mechanism with Long-Range Rigidity Transmission across Protein Networks

Protein Assembly: Defining the Strength of Protein-Protein Interactions Coupling the Theory with Experiments

Network Re-Wiring during Allostery and Protein-Protein Interactions: A Graph Spectral Approach

Topology Results on Adjacent Amino Acid Networks of Oligomeric Proteins

Community Network Analysis of Allosteric Proteins

The PyInteraph Workflow for the Study of Interaction Networks Form Protein Structural Ensembles

The Allosteric Effect in Antibody-Antigen Recognition

Distal Regions Regulate Dihydrofolate Reductase-Ligand Interactions

Investigating Conformational Dynamics and Allostery in the p53 DNA-Binding Domain Using Molecular Simulations

Molecular Dynamics Simulation Techniques as a Tool in Drug Discovery and Pharmacology: A Focus on Allosteric Drugs

Cooperativity and Allostery in RNA Systems.

Other Format:

Printed edition:

ISBN:

978-1-0716-1154-8

9781071611548

Access Restriction:

Restricted for use by site license.