From Obesity to Diabetes / edited by Juergen Eckel, Karine Clément.

Format:

Book

Contributor:

Eckel, Juergen, editor.

Clément, Karine, editor.

Series:

Handbook of Experimental Pharmacology, 1865-0325 ; 274

Language:

English

Subjects (All):

Pharmacology.

Metabolism--Disorders.

Metabolism.

Metabolic Disease.

Local Subjects:

Pharmacology.

Metabolic Disease.

Physical Description:

1 online resource (508 pages)

Edition:

1st ed. 2022.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2022.

Summary:

Obesity is a major risk factor for the development of type 2 diabetes and its associated complications, a major socio-economic burden for health care systems. The worldwide prevalence of obesity doubled since 1980 and as a consequence the number of patients with diabetes has been continuously rising with more than 450 Mio. people suffering from this disease at the present time. Substantial progress has been made in understanding the molecular pathways leading from excessive fat accumulation to metabolic perturbation and finally diabetes manifestation. This edition of the "Handbook of Experimental Pharmacology" aims to analyze new insight into the pathophysiology of obesity, to decipher the complex links to diabetes and its complications, and to collect most recent information on new strategies for prevention and treatment of obesity and diabetes.

Contents:

Part I Obesity. Epidemiology of Obesity

The Circadian Clock and Obesity

Nutrition and Microbiome

From Obesity to Diabetes: The Role of the Adipose Organ

Targeting Epicardial Fat in Obesity and Diabetes Pharmacotherapy

The Enteroendocrine System in Obesity

Insights from Studies of White Adipose Tissue Using Single-Cell Approaches

Obesity-Related Insulin Resistance: The Central Role of Adipose Tissue Dysfunction

Obesity, Senescence, and Senolytics

Obesity and Obstructive Sleep Apnea

Part II Diabetes and Complications. Inter-Organ Crosstalk in the Development of Obesity-Associated Insulin Resistance

Islet Inflammation and β Cell Dysfunction in Type 2 Diabetes

NAFLD and NASH: The Metabolically Diseased Liver

Diabetic Kidney Disease: From Pathogenesis to Novel Treatment Possibilities

Diabetic Peripheral Neuropathy

Part III Lifestyle Modifications and Future Treatments. Weight Loss Strategies

PhysicalActivity, Obesity and Weight Loss Maintenance

Bariatric/Metabolic Surgery

Drugs for Treating Obesity

Novel Drugs for Diabetes Therapy

Novel Approaches to Restore Pancreatic Beta-Cell Mass and Function

Precision Medicine and Obesity

Targeting the Enteroendocrine System for Treatment of Obesity.

Notes:

Includes bibliographical references and index.

ISBN:

3-030-99995-5

OCLC:

1337199954