Drug Delivery : Engineering principles for drug therapy / W. Mark Saltzman.

Format:

Book

Author/Creator:

Saltzman, W. Mark, author.

Series:

Topics in chemical engineering (Oxford University Press)

Language:

English

Subjects (All):

Polymers.

Pharmacokinetics.

Biomedical materials.

Drug delivery systems.

Physical Description:

1 online resource (xi, 372 pages). : illustrations

Edition:

1st ed.

Place of Publication:

Oxford : Oxford University Press, Incorporated, 2001.

Summary:

This text is a synthesis of the principles that govern rates of drug transport, reaction, and disappearance in physiological and pathological situations, providing a working foundation for those in the field of drug delivery. The book covers advanced drug delivery and contemporary biomaterials.

Contents:

Intro

Contents

Part I: Introductory material

1 Introduction

1.1 Historical perspective

1.2 The aim and structure of this book

2 Drug administration and drug effectiveness

2.1 The state of the art

2.2 Two views of the future

Summary

Part II: Fundamentals

3 Diffusion and drug dispersion

3.1 Random walks

3.2 Equations for the diffusive flux (Fick's law)

3.3 Equations of mass conservation (Fick's second law)

3.4 Solutions to the diffusion equation with no solute elimination or generation

3.5 Solutions to the diffusion equation with solute binding and elimination

3.6 A few applications

4 Diffusion in biological systems

4.1 Measurement of diffusion coefficients

4.2 Diffusion in water

4.3 Diffusion in polymer solutions and gels

4.4 Diffusion in the extracellular space

4.5 Diffusion with binding in tissues

4.6 Diffusion within cells

4.7 Diffusion and reaction

5 Drug permeation through biological barriers

5.1 Mobility of lipids and proteins in the membrane

5.2 Permeation through lipid membranes

5.3 Permeation through porous membranes

5.4 Permeation is enhanced by membrane proteins

5.5 Permeation through cell layers

6 Drug transport by fluid motion

6.1 Blood movement in the circulatory system

6.2 Interstitial fluid movement

6.3 Fluid movement in the lymphatic circulation

6.4 Fluid movement in the brain

7 Pharmacokinetics of drug distribution

7.1 Compartmental models

7.2 Physiological models

7.3 Patterns of mixing in tissues and organs

7.4 The problem of scale

Part III: Drug delivery systems

8 Drug modification

8.1 Enhancing agent solubility

8.2 Enhancing agent stability

8.3 Regulating agent permeability

8.4 Drug targeting and drug valency

Summary.

9 Controlled drug delivery systems

9.1 Reservoir and transdermal delivery systems

9.2 Matrix delivery systems

9.3 Hydrogel delivery systems

9.4 Degradable delivery systems

9.5 Particulate delivery systems

9.6 Responsive delivery systems

10 Case studies in drug delivery

10.1 Controlled delivery of systemic therapy

10.2 Implants for local drug delivery

10.3 Topically applied devices for controlled release

11 Postscript

Appendix A: Overview of polymeric biomaterials

A.1 Non-degradable polymers

A.1.1 Silicone elastomers

A.1.2 Poly[ethylene-co-(vinyl acetate)]

A.1.3 Polyurethanes

A.1.4 Other important polymers

A.2 Biodegradable polymers

A.2.1 Polyesters

A.2.2 Copolymers of methyl vinyl ether and maleic anhydride

A.2.3 Poly(ortho esters)

A.2.4 Polyanhydrides

A.2.5 Poly(amino acids)

A.2.6 Phosphorus-containing polymers

A.2.7 Polycarbonates and poly(iminocarbonates)

A.2.8 Polydioxanone

A.3 Water-soluble polymers

A.3.1 Naturally occurring polymers

A.3.2 Acrylates and acrylamides

A.3.3 Poly(ethylene glycol)

Appendix B: Useful data and nomenclature

B.1 Physiological parameters

B.2 Cardiovascular system

B.3 Clinical chemistry

B.4 Permeation and diffusion

B.5 Protein properties

B.6 Mathematical tables and functions

B.7 Nomenclature

Index

A

B

C

D

E

F

G

H

I

K

L

M

N

O

P

R

S

T

V

W.

Notes:

Includes bibliographical references and index.

Description based on publisher supplied metadata and other sources.

ISBN:

9780198024699

019802469X

OCLC:

133160689