Botulinum toxin treatment of pain disorders / Bahman Jabbari.

Format:

Book

Author/Creator:

Jabbari, Bahman, author.

Language:

English

Subjects (All):

Botulinum toxin--Therapeutic use.

Botulinum toxin.

Physical Description:

1 online resource (438 pages)

Edition:

2nd ed.

Place of Publication:

Cham, Switzerland : Springer, [2022]

Summary:

This book provides an authoritative overview of botulinum neurotoxin (BoNT) treatment menus for 16 pain categories with an evidence-based literature review on each pain disorder, illustrative figures showing anatomy and techniques Introductory chapters cover basic information about the mechanism, function and the analgesic effects of the BoNTs based on the data derived from animal studies. Clinical chapters define pain in conditions such as post-herpetic and post-traumatic neuralgias, plantar fasciitis, low back pain, post-surgical pain syndromes and migraine in detail, provide discussion of current modes of treatment and updated information on BoNT therapy. Each chapter also includes illustrative case histories. The new edition is updated with all the new findings since the explosion in research and literature since 2015. New chapters on the history and pain in dentistry round out the update. Botulinum Toxin Treatment of Pain Disorders provides an invaluable resource for clinicians and researchers involved in the treatment of pain disorders including neurologists, pain medicine specialists, anesthesiologists, internists, those conducting research in pharmacology and toxicology as well as students in these areas.

Contents:

Intro

Preface

Contents

Chapter 1: The History of Botulinum Neurotoxin Development

Introduction

Biology and Basic Science

Neurologists: Clinical Neurotoxicologists in the United States

PREEMPT Group (Drs. Silberstien, Dodick, Aurora, Lipton, Blumenfeld, and Others)

Germany

Austria

References

Chapter 2: Molecular Structure, Mode of Action, Immunology, Safety, and Side Effects of BoNTs

Structure of Botulinum Neurotoxin and Its Mode of Action

Diffusion and Spread of Neurotoxins

Immunology of BoNTs

Side Effects of BoNTs

Chapter 3: Analgesic Effects of Botulinum Neurotoxins: Data from Animal Studies Volunteers

Pathophysiology of Pain at Peripheral and Central Levels

Pain Modulation

Data from Animal Studies

Effect of Botulinum Toxins on Pain Channels and Receptors

Effect on Sodium Channels

Effect on Transient Receptor Potentials (TRP) Channels

Effect on Purinergic Channels

The Role of Nerve Growth Factor (NGF) in Pain

The Effects of Botulinum Toxins on Inflammation

Spinal Cord Gabaergic Neurons and Pain: Effects of Botulinum Toxins

Effects of Botulinum Toxins on Opioid Channels

Opioid Receptors

BoNT Effects on Nerve Regeneration and Nerve Recovery

Evidence for Central Analgesic Effect of Botulinum Neurotoxins

Additional Mechanisms Potentially Promoting the Analgesic Effects of BoNTs in Pain

Conclusion

Chapter 4: Botulinum Toxin Therapy for Neuropathic Pain (NP)

Neuropathic Pain: Definition and Pathophysiology

Postherpetic Neuralgia (PHN)

Treatment

BoNT Studies in Postherpetic Neuralgia (PHN)

Case Report

Comment

The Effect of Botulinum Toxin on Itch Associated with PHN

Posttraumatic Neuralgia

BoNT Treatment of Posttraumatic Neuralgia

Case Report.

Metabolic and Drug-Induced Painful Peripheral Neuropathies

Diabetic Neuropathy

Pathophysiology

Treatment of Painful Diabetic Neuropathy (PDN)

BoNT Treatment in Diabetic Neuropathy

Painful Neuropathy Related to Drugs and Chemotherapeutic Agents

Complex Regional Pain Syndrome

Treatment of Complex Regional Pain Syndrome

BoNT Treatment of CRPS

Residual Limb Pain and Phantom Pain

Pharmacological Treatment

BoNT Treatment of RLP and PLP

Chapter Conclusion

Chapter 5: Botulinum Toxin Treatment in Migraine and Other Headaches

Migraine

Therapeutic Use of Calcitonin Gene-Related Peptide (CGRP) Inhibitors

Botulinum Neurotoxin for Preventive Treatment of Migraine

Episodic Migraine (EM)

Chronic Migraine

BoNT Injection Technique in Chronic Migraine

Patient Report

The Issue of Medication Overuse in Chronic Migraine

Long-Term Response to BoNTs in Chronic Migraine and Safety Issues

Imploding Versus Exploding Migraine

BoNT Treatment in Pediatric Chronic Migraine

Treatment of Chronic Migraine with Other Botulinum Toxins

IncobotulinumtoxinA (Xeomin)

The Mechanism of Action of OnabotulinumtoxinA (onaA) in Chronic Migraine

Comparison of Botulinum Toxin Treatment and CGRP Treatment

Tension-Type Headache (TTH)

BoNT Treatment of Tension-Type Headache (TTH)

Chronic Daily Headaches (CDH)

Trigeminal Autonomic Cephalalgias (TAC)

Cluster Headaches

BoNT Treatment of Cluster Headaches

Posttraumatic Headaches (PTH)

Botulinum Toxin Treatment of Posttraumatic Headaches

Chapter 6: Botulinum Neurotoxins and Chronic Low Back Pain

Introduction.

Anatomy of Low Back Muscles

Pathophysiology of Chronic Low Back Pain

Medical Treatment of Chronic Low Back Pain

Evidence for Efficacy of BoNTs in Chronic Low Back Pain

Studies

How Does the Administration of Botulinum Toxin Improve Low Back Pain?

Chapter 7: Botulinum Toxin Treatment of Plantar Fasciitis (Plantar Fasciopathy)

Anatomy of Plantar Fascia

Pathophysiology of Plantar Fasciitis

Treatment of Plantar Fasciitis

BoNT Treatment of Plantar Fasciitis

Comparator Studies

How Does BoNT Injections Improve Pain in Plantar Fasciitis?

Chapter 8: Botulinum Toxin Treatment of Myofascial Pain Syndrome and Fibromyalgia

Anatomy and Pathophysiology of Myofascial Pain Syndrome (MFPS)

BoNT Treatment of Myofascial Pain Syndrome (MPS)

Double-Blind, Placebo-Controlled Studies

Case Reports

Patient (8-1): Myofascial Pain Syndrome with Two Trigger Points in One Muscle

Patient (8-2): Multiple Trigger Points in Multiple Muscles

Comment on the Efficacy of BoNT Therapy in Myofascial Pain Syndrome

The Mechanism of Action of BoNTs in Myofascial Pain Syndrome (MPS)

Fibromyalgia

Botulinum Toxin Treatment of Fibromyalgia

Chapter 9: Botulinum Toxin Therapy for Pelvic and Urogenital Pain

Anatomy of the Pelvic Floor

Treatment of Chronic Pelvic Pain

Botulinum Toxin Treatment of Chronic Pelvic Pain

Rational

Botulinum Neurotoxins Studies in Chronic Pelvic Pain (CPP)

Botulinum Toxin Treatment of Dyspareunia and Vaginismus

Vulvodynia

Painful Bladder Disorders

Botulinum Toxin Treatment of BPS/IC

Injection Technique

The Proposed Mechanisms of BoNT Action in Bladder Pain.

Comment

Chapter 10: Botulinum Toxin Treatment of Chronic Facial Pain: Trigeminal Neuralgia and Temporo-Mandibular Disorders

Trigeminal Neuralgia (TN)

Pharmacologic Treatment

Surgical Treatment

Anatomy and Physiology of Trigeminal Sensory System

Botulinum Toxin Treatment of Trigeminal Neuralgia

Human Studies of BoNTs in Trigeminal Neuralgia

Temporomandibular Disorder (TMD)

Botulinum Toxin Treatment of TMD

Case Report (10-2)

Chapter 11: Botulinum Neurotoxins for Relief of Pain Associated with Spasticity

Pathophysiology of Spasticity and Spasticity Related Pain (SRP)

Treatment of Spasticity

Nonpharmacological Treatment of Spasticity

Pharmacological Therapy

Procedural Approaches and Surgical Interventions

Botulinum Toxin Studies in Spasticity That Have Included Assessment of Pain

Upper Limb Spasticity-Related Pain in Adults

Case 11-1

Lower Limb Spasticity-Related Pain of Adults

Case 2

Effects of BoNT Treatment on Pain of Children with Cerebral Palsy and Spasticity

The Mechanism of Action of BoNTs in Spasticity-Related Pain (SRP)

Chapter 12: Treatment of Dystonic Pain with Botulinum Neurotoxins

Cervical Dystonia

Effects of BoNTs on Pain Associated with Cervical Dystonia

Same Toxin, Different Doses

Different Toxins

Case 12.1

Botulinum Toxin Treatment of Painful Dystonia in Neurodegenerative Disorders

Case 12-2

Case -12-3

Post-traumatic Dystonia

Case 12-4

Chapter 13: Botulinum Toxin Treatment of Piriformis Syndrome

Anatomy

Pathophysiology of the Piriformis Syndrome.

Treatment of the Piriformis Syndrome (PS)

Botulinum Toxin Treatment of Piriformis Syndrome

Double-Blind, Placebo-Controlled Studies of BoNTs in Piriformis Syndrome

Technical Points

The Mechanism of Botulinum Toxin Action in Piriformis Syndrome

Chapter 14: Botulinum Toxin Therapy for Prevention of Postsurgical Pain

Postmastectomy Breast Reconstruction

Botulinum Toxin Treatment of Pain After Breast Reconstructive Surgery

Posthemorrhoidectomy Pain

Treatment of Posthemorrhoidectomy Pain

Botulinum Toxin Treatment of Posthemorrhoidectomy Pain

Blinded, Placebo Controlled Studies

Randomized, Controlled Study

Prospective, Randomized Comparator Studies

Prevention and Reduction of Posthernia Repair Pain

Reduction of Severe Pain After Adductor Release Surgery

Chapter 15: Botulinum Toxins (BoNTs) for Treatment of Pain in Orthopedic Disorders

Chronic Lateral Epicondylitis (CLE)

Botulinum Neurotoxin Studies in CLE

Placebo-Controlled Studies

Botulinum Toxin Treatment

Botulinum Neurotoxin Treatment after Total Knee Arthroplasty

Knee Pain with Vastus Lateralis Imbalance

Comments on the Use of BoNT Injections for Pain After Knee Arthroplasty and Vastus Lateralis Imbalance (Patellofemoral Syndrome)

Chapter 16: Botulinum Toxin in Dentistry and Treatment of Chronic Orofacial Pain

Chronic Orofacial Pain

Musculoskeletal Orofacial Pain

Temporomandibular Disorders (TMDs)

Definition, Classification, and Epidemiology

Management of Temporomandibular Disorders.

Efficacy of BoNT in the Treatment of Temporomandibular Disorders with Pain.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

Other Format:

Print version: Jabbari, Bahman Botulinum Toxin Treatment of Pain Disorders

ISBN:

9783030996505