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Pharmaceutical crystals : science and engineering / edited by Tonglei Li, Alessandra Mattei.
- Format:
- Book
- Series:
- THEi Wiley ebooks.
- THEi Wiley ebooks
- Language:
- English
- Subjects (All):
- Crystals--Structure.
- Crystals.
- Pharmaceutical chemistry.
- Drug development.
- Physical Description:
- 1 online resource (541 pages)
- Edition:
- First edition.
- Place of Publication:
- Hoboken, NJ : John Wiley & Sons, [2019]
- System Details:
- Access using campus network via VPN at home (THEi Users Only).
- Summary:
- An important resource that puts the focus on understanding and handling of organic crystals in drug development Since a majority of pharmaceutical solid-state materials are organic crystals, their handling and processing are critical aspects of drug development. Pharmaceutical Crystals: Science and Engineering offers an introduction to and thorough coverage of organic crystals, and explores the essential role they play in drug development and manufacturing. Written contributions from leading researchers and practitioners in the field, this vital resource provides the fundamental knowledge and explains the connection between pharmaceutically relevant properties and the structure of a crystal. Comprehensive in scope, the text covers a range of topics including: crystallization, molecular interactions, polymorphism, analytical methods, processing, and chemical stability. The authors clearly show how to find solutions for pharmaceutical form selection and crystallization processes. Designed to be an accessible guide, this book represents a valuable resource for improving the drug development process of small drug molecules. This important text: * Includes the most important aspects of solid-state organic chemistry and its role in drug development * Offers solutions for pharmaceutical form selection and crystallization processes * Contains a balance between the scientific fundamental and pharmaceutical applications * Presents coverage of crystallography, molecular interactions, polymorphism, analytical methods, processing, and chemical stability Written for both practicing pharmaceutical scientists, engineers, and senior undergraduate and graduate students studying pharmaceutical solid-state materials, Pharmaceutical Crystals: Science and Engineering is a reference and textbook for understanding, producing, analyzing, and designing organic crystals which is an imperative skill to master for anyone working in the field.
- Contents:
- Crystallography
- Nucleation
- Solid-state characterization techniques
- Intermolecular interactions and computational modeling
- Polymorphism and phase transitions
- Measurement and mathematical relationships of cocrystal thermodynamic properties
- Mechanical properties
- Primary processing of organic crystals
- Secondary processing of organic crystals
- Chemical stability and reaction
- Crystalline nanoparticles.
- Notes:
- Includes bibliographical references and index.
- Description based on print version record.
- ISBN:
- 9781119046349
- 1119046343
- 9781119046202
- 1119046203
- 9781119046233
- 1119046238
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