Mitochondrial dysfunction caused by drug and environmental toxicants / edited by Yvonne Will, James A. Dykens.

Format:

Book

Contributor:

Will, Yvonne, editor.

Dykens, James A., editor.

Language:

English

Subjects (All):

Drugs--Toxicology.

Drugs.

Mitochondrial pathology.

Physical Description:

1 online resource (744 pages) : illustrations

Place of Publication:

Hoboken, New Jersey : Wiley, 2018.

Summary:

Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods • Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects • Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development • Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria

Contents:

v.1 Contributions of plasma protein binding and membrane transporters to drug-induced mitochondrial toxicity

The role of transporters in drug accumulation and mitochonrial toxicity

Structure-activity modeling of mitochondrial dysfunction

v. 2. Statin fibrate-induced dichotomy of mitochondrial function

Friend or foe : can mitochondrial toxins lead to similar benefits as exercise?

Involvement of mitochondrial dysfunction on the toxic effects caused by drugs of abuse and addiction.

Notes:

Includes bibliographical references and index.

Description based on print version record.

ISBN:

9781119329749

1119329744

9781119329732

1119329736

9781119329725

1119329728