Stem cells in birth defects research and developmental toxicology / edited by Theodore P. Rasmussen.

Format:

Book

Contributor:

Rasmussen, Theodore P., 1962- editor.

Language:

English

Subjects (All):

Stem cells--Research.

Stem cells.

Abnormalities, Human.

Physical Description:

1 online resource (1 volume (unpaged))

Edition:

First edition.

Place of Publication:

Hoboken, NJ : Wiley, 2018.

Summary:

This book contains material contributed by forward-looking scientists who work at the interface of stem cell research and applied science with the aim to improve human fetal safety and the understanding of human developmental and degenerative disorders. Provides important platforms and contemporary accounts of the state of stem cell research in the fields of toxicology and teratology. Considers both in vitro uses of stem cells as platforms for teratology and also stem cellopathies, which are in vivo developmental and degenerative disorders. Helps the pharmaceutical industry and safety and environmental authorities validate the status quo of in vitro toxicity test systems based on human pluripotent stem cells and their derivatives"--Provided by publisher.

Contents:

The Basics of Stem Cells and Their Utility as Platforms to Model Teratogen Action and Human Developmental and Degenerative Disorders

Bindu Prabhakar, Soowan Lee, and Theodore P. Rasmussen

Stem Cells and Tissue Engineering Technologies for Advancing Human Teratogen Screening

Jiangwa Xing, Geetika Sahni and Yi-Chin Toh

Use of Embryoid Bodies for the Detection of Teratogens and Analysis of Teratogenic Mechanisms

Anthony Flamier

Stem-Cell-Based In vitro Morphogenesis Models to Investigate Developmental Toxicity of Chemical Exposures

Yusuke Marikawa

RIsk Assessment Using Human Pluripotent Stem Cells: Recent Advances in Developmental Toxicity Screens

Kristen Buck and Nicole I. zur Nieden

Modeling the Brain in the Culture Dish: Advancements and Applications of Induced Pluripotent Stem-Cell-Derived Neurons

Sandhya Chandrasekaran, Prashanth Rajarajan, Schahram Akbarian, and Kristen Brennand

Modeling Genetic and Environment Interactions Relevant to Huntington's and Parkinson's Disease in Human Induced Pluripotent Stem Cells (hiPSCs)-Derived Neurons

Piyush Joshi, M. Diana Neely, and Aaron B. Bowman

Alcohol Effects on Adult Neural Stem Cells

A Novel Mechanism of Neurotoxicity and Recovery in Alcohol Use Disorders

Rachael A. Olsufka, Hui Peng, Jessica S. Newton, and Kimberly Nixon

Fetal Alcohol Spectrum Disorders: A Stem-Cellopathy?

Amanda H. Mahnke, Nihal A. Salem, Alexander M. Tseng, Annette S. Fincher, Andrew Klopfer, and Rajesh C. Miranda

Toxicological Responses in Keratinocyte Interfollicular Stem Cells

Rambon Shamilov and Brian J. Aneskievich

Stem-Cell Microscale Platforms for Toxicology Screening

Tiago G. Fernandes and Joaquim M.S. Cabral

HepaRG Cells as a Model for Hepatotoxicity Studies

André Guillouzo and Christiane Guguen-Guillouzo.

Notes:

Includes bibliographical references and index.

Description based on print version record.

ISBN:

9781119283232

111928323X

9781119283225

1119283221

9781119283249

1119283248